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C-reactive protein concentrations and level of physical activity in men and women with normal and impaired glucose tolerance : A cross-sectional population-based study in Sweden

Hellgren, Margareta I.; Larsson, Charlotte A. LU ; Daka, Bledar; Petzold, Max; Jansson, Per Anders and Lindblad, Ulf (2016) In Journal of Physical Activity & Health 13(6). p.625-631
Abstract

Background: We aimed to explore the association between self-reported leisure time physical activity (LTPA) and C-reactive protein (CRP) concentrations in men and women with and without impaired glucose tolerance (IGT). Methods: In a cross-sectional study, a random sample (n = 2,816) was examined with an oral glucose tolerance test, CRP and information about LTPA. Those with IGT or normal glucose tolerance (NGT) and CRP value ≤10 mg/L were selected (n = 2,367) for the study. Results: An inverse association between LTPA and CRP concentrations was observed in the population (P <.001), though, only in men with IGT (P = .023) and in women with NGT. Men with IGT, reporting slight physical activity up to 4 hours a week presented... (More)

Background: We aimed to explore the association between self-reported leisure time physical activity (LTPA) and C-reactive protein (CRP) concentrations in men and women with and without impaired glucose tolerance (IGT). Methods: In a cross-sectional study, a random sample (n = 2,816) was examined with an oral glucose tolerance test, CRP and information about LTPA. Those with IGT or normal glucose tolerance (NGT) and CRP value ≤10 mg/L were selected (n = 2,367) for the study. Results: An inverse association between LTPA and CRP concentrations was observed in the population (P <.001), though, only in men with IGT (P = .023) and in women with NGT. Men with IGT, reporting slight physical activity up to 4 hours a week presented significantly higher CRP concentrations than normoglycemic men (Δ0.6 mg/L, P = .004). However, this difference could not be found in men with IGT reporting more intense physical activity (Δ0.01 mg/L, P = .944). Conclusions: Physical inactivity seems to have greater inflammatory consequences for men (vs. women) with IGT. More importantly, although 4 hours of physical activity per week is more than the usual minimum recommendation, an even greater intensity of LTPA appears to be required to limit subclinical inflammation in men with IGT.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gender differences, Glucose metabolism, Inflammation
in
Journal of Physical Activity & Health
volume
13
issue
6
pages
7 pages
publisher
Human Kinetics, Inc.
external identifiers
  • Scopus:84977616301
  • WOS:000378760600009
ISSN
1543-3080
DOI
10.1123/jpah.2015-0168
language
English
LU publication?
yes
id
15ff3014-8108-4e78-95c2-071e1c0605ed
date added to LUP
2016-07-25 14:58:11
date last changed
2017-01-01 08:31:06
@article{15ff3014-8108-4e78-95c2-071e1c0605ed,
  abstract     = {<p>Background: We aimed to explore the association between self-reported leisure time physical activity (LTPA) and C-reactive protein (CRP) concentrations in men and women with and without impaired glucose tolerance (IGT). Methods: In a cross-sectional study, a random sample (n = 2,816) was examined with an oral glucose tolerance test, CRP and information about LTPA. Those with IGT or normal glucose tolerance (NGT) and CRP value ≤10 mg/L were selected (n = 2,367) for the study. Results: An inverse association between LTPA and CRP concentrations was observed in the population (P &lt;.001), though, only in men with IGT (P = .023) and in women with NGT. Men with IGT, reporting slight physical activity up to 4 hours a week presented significantly higher CRP concentrations than normoglycemic men (Δ0.6 mg/L, P = .004). However, this difference could not be found in men with IGT reporting more intense physical activity (Δ0.01 mg/L, P = .944). Conclusions: Physical inactivity seems to have greater inflammatory consequences for men (vs. women) with IGT. More importantly, although 4 hours of physical activity per week is more than the usual minimum recommendation, an even greater intensity of LTPA appears to be required to limit subclinical inflammation in men with IGT.</p>},
  author       = {Hellgren, Margareta I. and Larsson, Charlotte A. and Daka, Bledar and Petzold, Max and Jansson, Per Anders and Lindblad, Ulf},
  issn         = {1543-3080},
  keyword      = {Gender differences,Glucose metabolism,Inflammation},
  language     = {eng},
  month        = {06},
  number       = {6},
  pages        = {625--631},
  publisher    = {Human Kinetics, Inc.},
  series       = {Journal of Physical Activity & Health},
  title        = {C-reactive protein concentrations and level of physical activity in men and women with normal and impaired glucose tolerance : A cross-sectional population-based study in Sweden},
  url          = {http://dx.doi.org/10.1123/jpah.2015-0168},
  volume       = {13},
  year         = {2016},
}