High-throughput genomic technology in research and clinical management of breast cancer. Molecular signatures of progression from benign epithelium to metastatic breast cancer.
Rennstam, Karin LU and Hedenfalk, Ingrid LU
(2006)
In Breast Cancer Research
8:213(4).
- Abstract
- It is generally accepted that early detection of breast cancer has great impact on patient survival, emphasizing the importance of early diagnosis. In a widely recognized model of breast cancer development, tumor cells progress through chronological and well defined stages. However, the molecular basis of disease progression in breast cancer remains poorly understood. High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations. By accurately mapping changes in the genome and subsequent biological/molecular pathways, the chances of finding potential novel treatment targets as well as intervention strategies are enhanced, and ultimately lives can be saved. This review provides a brief... (More)
- It is generally accepted that early detection of breast cancer has great impact on patient survival, emphasizing the importance of early diagnosis. In a widely recognized model of breast cancer development, tumor cells progress through chronological and well defined stages. However, the molecular basis of disease progression in breast cancer remains poorly understood. High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations. By accurately mapping changes in the genome and subsequent biological/molecular pathways, the chances of finding potential novel treatment targets as well as intervention strategies are enhanced, and ultimately lives can be saved. This review provides a brief summary of recent progress in identifying molecular markers for invasiveness in early breast lesions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/160207
- author
- Rennstam, Karin
LU
and Hedenfalk, Ingrid
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Breast Cancer Research
- volume
- 8:213
- issue
- 4
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000240767500006
- scopus:33846896651
- pmid:16895590
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr1528
- language
- English
- LU publication?
- yes
- id
- e7b6a243-f3eb-49a4-909c-2a279e163f84 (old id 160207)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16895590&dopt=Abstract
- date added to LUP
- 2016-04-01 11:47:00
- date last changed
- 2022-01-26 18:07:59
@article{e7b6a243-f3eb-49a4-909c-2a279e163f84,
abstract = {{It is generally accepted that early detection of breast cancer has great impact on patient survival, emphasizing the importance of early diagnosis. In a widely recognized model of breast cancer development, tumor cells progress through chronological and well defined stages. However, the molecular basis of disease progression in breast cancer remains poorly understood. High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations. By accurately mapping changes in the genome and subsequent biological/molecular pathways, the chances of finding potential novel treatment targets as well as intervention strategies are enhanced, and ultimately lives can be saved. This review provides a brief summary of recent progress in identifying molecular markers for invasiveness in early breast lesions.}},
author = {{Rennstam, Karin and Hedenfalk, Ingrid}},
issn = {{1465-5411}},
language = {{eng}},
number = {{4}},
publisher = {{BioMed Central (BMC)}},
series = {{Breast Cancer Research}},
title = {{High-throughput genomic technology in research and clinical management of breast cancer. Molecular signatures of progression from benign epithelium to metastatic breast cancer.}},
url = {{http://dx.doi.org/10.1186/bcr1528}},
doi = {{10.1186/bcr1528}},
volume = {{8:213}},
year = {{2006}},
}