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High-throughput genomic technology in research and clinical management of breast cancer. Molecular signatures of progression from benign epithelium to metastatic breast cancer.

Rennstam, Karin LU and Hedenfalk, Ingrid LU orcid (2006) In Breast Cancer Research 8:213(4).
Abstract
It is generally accepted that early detection of breast cancer has great impact on patient survival, emphasizing the importance of early diagnosis. In a widely recognized model of breast cancer development, tumor cells progress through chronological and well defined stages. However, the molecular basis of disease progression in breast cancer remains poorly understood. High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations. By accurately mapping changes in the genome and subsequent biological/molecular pathways, the chances of finding potential novel treatment targets as well as intervention strategies are enhanced, and ultimately lives can be saved. This review provides a brief... (More)
It is generally accepted that early detection of breast cancer has great impact on patient survival, emphasizing the importance of early diagnosis. In a widely recognized model of breast cancer development, tumor cells progress through chronological and well defined stages. However, the molecular basis of disease progression in breast cancer remains poorly understood. High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations. By accurately mapping changes in the genome and subsequent biological/molecular pathways, the chances of finding potential novel treatment targets as well as intervention strategies are enhanced, and ultimately lives can be saved. This review provides a brief summary of recent progress in identifying molecular markers for invasiveness in early breast lesions. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Breast Cancer Research
volume
8:213
issue
4
publisher
BioMed Central (BMC)
external identifiers
  • wos:000240767500006
  • scopus:33846896651
  • pmid:16895590
ISSN
1465-5411
DOI
10.1186/bcr1528
language
English
LU publication?
yes
id
e7b6a243-f3eb-49a4-909c-2a279e163f84 (old id 160207)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16895590&dopt=Abstract
date added to LUP
2016-04-01 11:47:00
date last changed
2021-10-06 02:41:25
@article{e7b6a243-f3eb-49a4-909c-2a279e163f84,
  abstract     = {It is generally accepted that early detection of breast cancer has great impact on patient survival, emphasizing the importance of early diagnosis. In a widely recognized model of breast cancer development, tumor cells progress through chronological and well defined stages. However, the molecular basis of disease progression in breast cancer remains poorly understood. High-throughput molecular profiling techniques are excellent tools for the study of complex molecular alterations. By accurately mapping changes in the genome and subsequent biological/molecular pathways, the chances of finding potential novel treatment targets as well as intervention strategies are enhanced, and ultimately lives can be saved. This review provides a brief summary of recent progress in identifying molecular markers for invasiveness in early breast lesions.},
  author       = {Rennstam, Karin and Hedenfalk, Ingrid},
  issn         = {1465-5411},
  language     = {eng},
  number       = {4},
  publisher    = {BioMed Central (BMC)},
  series       = {Breast Cancer Research},
  title        = {High-throughput genomic technology in research and clinical management of breast cancer. Molecular signatures of progression from benign epithelium to metastatic breast cancer.},
  url          = {http://dx.doi.org/10.1186/bcr1528},
  doi          = {10.1186/bcr1528},
  volume       = {8:213},
  year         = {2006},
}