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The airway epithelium as regulator of inflammation patterns in asthma

Erjefält, Jonas LU (2010) In Clinical Respiratory Journal 4(s1). p.9-14
Abstract
Introduction: Asthma is a complex, heterogeneous and mutifactorial disease and represents a major health problem in Westernised countries. The airway epithelium, with its direct physical contact with luminal triggers, has a major role in determining the nature of inflammation that develops in asthmatic airways. Objective: The present review aims to provide a brief overview of the numerous ways the airway epithelium can affect and influence the histopathological picture in asthma. Results and Conclusion: The ways the epithelium aggravates inflammation range from acute responses to luminal triggers such as allergens and infections to the multipathogenic events occurring as a consequence of repeated epithelial damage-repair responses. The... (More)
Introduction: Asthma is a complex, heterogeneous and mutifactorial disease and represents a major health problem in Westernised countries. The airway epithelium, with its direct physical contact with luminal triggers, has a major role in determining the nature of inflammation that develops in asthmatic airways. Objective: The present review aims to provide a brief overview of the numerous ways the airway epithelium can affect and influence the histopathological picture in asthma. Results and Conclusion: The ways the epithelium aggravates inflammation range from acute responses to luminal triggers such as allergens and infections to the multipathogenic events occurring as a consequence of repeated epithelial damage-repair responses. The airway epithelium also facilitates the selective migration of leukocytes into the airway lumen, a process that is important in regulating inflammatory cell homeostasis. The fact that only some of the important leukocyte subtypes participate in this process cause translational problems and difficulties in the interpretation of luminal samples. To further reveal the nature of the multifaceted involvement of the airway epithelium in inflamed asthmatic airways emerges as a promising goal for identifying new therapeutic strategies. Please cite this paper as: Erjefalt JS. The airway epithelium as regulator of inflammation patterns in asthma. Clin Respir J 2010; 4 (Suppl. 1): 9-14. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
inflammation, asthma, epithelium, repair
in
Clinical Respiratory Journal
volume
4
issue
s1
pages
9 - 14
publisher
Wiley-Blackwell
external identifiers
  • wos:000276695800002
  • pmid:20500604
  • scopus:77951101500
ISSN
1752-6981
DOI
10.1111/j.1752-699X.2010.00191.x
language
English
LU publication?
yes
id
4b75e4d9-66e6-4a23-8341-834391bddd35 (old id 1603205)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20500604?dopt=Abstract
date added to LUP
2010-05-19 09:26:06
date last changed
2018-05-29 10:08:34
@article{4b75e4d9-66e6-4a23-8341-834391bddd35,
  abstract     = {Introduction: Asthma is a complex, heterogeneous and mutifactorial disease and represents a major health problem in Westernised countries. The airway epithelium, with its direct physical contact with luminal triggers, has a major role in determining the nature of inflammation that develops in asthmatic airways. Objective: The present review aims to provide a brief overview of the numerous ways the airway epithelium can affect and influence the histopathological picture in asthma. Results and Conclusion: The ways the epithelium aggravates inflammation range from acute responses to luminal triggers such as allergens and infections to the multipathogenic events occurring as a consequence of repeated epithelial damage-repair responses. The airway epithelium also facilitates the selective migration of leukocytes into the airway lumen, a process that is important in regulating inflammatory cell homeostasis. The fact that only some of the important leukocyte subtypes participate in this process cause translational problems and difficulties in the interpretation of luminal samples. To further reveal the nature of the multifaceted involvement of the airway epithelium in inflamed asthmatic airways emerges as a promising goal for identifying new therapeutic strategies. Please cite this paper as: Erjefalt JS. The airway epithelium as regulator of inflammation patterns in asthma. Clin Respir J 2010; 4 (Suppl. 1): 9-14.},
  author       = {Erjefält, Jonas},
  issn         = {1752-6981},
  keyword      = {inflammation,asthma,epithelium,repair},
  language     = {eng},
  number       = {s1},
  pages        = {9--14},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Respiratory Journal},
  title        = {The airway epithelium as regulator of inflammation patterns in asthma},
  url          = {http://dx.doi.org/10.1111/j.1752-699X.2010.00191.x},
  volume       = {4},
  year         = {2010},
}