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Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort

Maria Huerta, Jose; Navarro, Carmen; Chirlaque, Maria-Dolores; Tormo, Maria-Jose; Steindorf, Karen; Buckland, Genevieve; Carneiro, Fatima; Johnsen, Nina Fons; Overvad, Kim and Stegger, Jakob, et al. (2010) In Cancer Causes and Control 21(5). p.657-669
Abstract
To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC). From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse). During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia... (More)
To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC). From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse). During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling. The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50-0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26-0.74, for non-cardia GAC). No effect was found for cardia tumours or histological subtypes of GAC. PA of any kind was not associated with OAC. Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
EPIC, Oesophagus cancer, Physical activity, Stomach cancer
in
Cancer Causes and Control
volume
21
issue
5
pages
657 - 669
publisher
Springer
external identifiers
  • wos:000276768500002
  • scopus:77955297532
ISSN
1573-7225
DOI
10.1007/s10552-009-9493-x
language
English
LU publication?
yes
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780f141f-1359-4ea9-bb6d-87faaf3a6d6e (old id 1603221)
date added to LUP
2010-05-19 09:32:16
date last changed
2018-06-10 03:08:25
@article{780f141f-1359-4ea9-bb6d-87faaf3a6d6e,
  abstract     = {To analyse the association between types of physical activity (occupational, recreational and household, vigorous and overall) and risk of primary oesophageal (OAC) or gastric adenocarcinoma (GAC). From nine European countries, 420,449 participants were recruited between 1991 and 2000 and followed-up for a mean of 8.8 years to register incident GAC and OAC. Information on physical activity (PA), diet, lifestyle and health-related variables was obtained at baseline. Helicobacter pylori infection status was considered in a subset of 1,211 participants. Analyses were repeated by tumour site (cardia/non-cardia) and histological type (intestinal/diffuse). During the follow-up, 410 GAC and 80 OAC occurred. A lower risk of overall and non-cardia GAC was found for increasing levels of a PA index which combined occupational PA with weekly time spent in sports and cycling. The hazard ratio (HR) of GAC was 0.69, 95% CI: 0.50-0.94, for the comparison between active and inactive participants according to the PA index (HR = 0.44, 95% CI:0.26-0.74, for non-cardia GAC). No effect was found for cardia tumours or histological subtypes of GAC. PA of any kind was not associated with OAC. Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach.},
  author       = {Maria Huerta, Jose and Navarro, Carmen and Chirlaque, Maria-Dolores and Tormo, Maria-Jose and Steindorf, Karen and Buckland, Genevieve and Carneiro, Fatima and Johnsen, Nina Fons and Overvad, Kim and Stegger, Jakob and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Morois, Sophie and Boeing, Heiner and Kaaks, Rudolf and Rohrmann, Sabine and Vigl, Matthaeus and Lagiou, Pagona and Trichopoulos, Dimitrios and Trichopoulou, Antonia and Bueno-de-Mesquita, H. Bas and Monninkhof, Evelyn M. and Numans, Mattijs E. and Peeters, Petra H. and Mattiello, Amalia and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Vineis, Paolo and Agudo, Antonio and Ardanaz, Eva and Arriola, Larraitz and Molina-Montes, Esther and Rodriguez, Laudina and Lindkvist, Bjoern and Manjer, Jonas and Stenling, Roger and Lund, Eiliv and Crowe, Francesca L. and Key, Timothy J. and Khaw, Kay-Tee and Wareham, Nicholas J. and Jenab, Mazda and Norat, Teresa and Romaguera, Dora and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {1573-7225},
  keyword      = {EPIC,Oesophagus cancer,Physical activity,Stomach cancer},
  language     = {eng},
  number       = {5},
  pages        = {657--669},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort},
  url          = {http://dx.doi.org/10.1007/s10552-009-9493-x},
  volume       = {21},
  year         = {2010},
}