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Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals

Nicholls, David LU (2010) Conference on Synaptopathies - Dysfunction of Synaptic Function In Biochemical Society Transactions 38. p.457-459
Abstract
Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated.
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
exocytosis, brain, potassium channel, glutamate, synaptosome
in
Biochemical Society Transactions
volume
38
pages
457 - 459
publisher
Portland Press
conference name
Conference on Synaptopathies - Dysfunction of Synaptic Function
external identifiers
  • wos:000276805000028
  • scopus:77953242704
ISSN
0300-5127
1470-8752
DOI
10.1042/BST0380457
language
English
LU publication?
yes
id
ea650883-8335-48f0-beff-5cf388e9f8bd (old id 1603289)
date added to LUP
2010-05-18 15:46:14
date last changed
2018-05-29 11:33:26
@inproceedings{ea650883-8335-48f0-beff-5cf388e9f8bd,
  abstract     = {Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated.},
  author       = {Nicholls, David},
  booktitle    = {Biochemical Society Transactions},
  issn         = {0300-5127},
  keyword      = {exocytosis,brain,potassium channel,glutamate,synaptosome},
  language     = {eng},
  pages        = {457--459},
  publisher    = {Portland Press},
  title        = {Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals},
  url          = {http://dx.doi.org/10.1042/BST0380457},
  volume       = {38},
  year         = {2010},
}