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Human antibody response towards the pneumococcal surface proteins PspA and PspC during invasive pneumococcal infection.

Linder, Adam LU ; Hollingshead, Susan; Janulczyk, Robert LU ; Christensson, Bertil LU and Åkesson, Per LU (2007) In Vaccine 25(2). p.341-345
Abstract
gG antibodies against pneumococcal surface protein A, family 1 (PspAl) and family 2 (PspA2), protein C (PspC), and protein Hic were investigated in 41 patients with invasive pneumococcal disease. Pre-existing antibody levels against the four pneumococcal proteins were not significantly different from those found in 40 patients with non-pneumococcal bacteremia or 80 healthy controls. However, during convalescense a strong immune response developed especially against PspA, and there was a high degree of cross-reactivity between PspA-and PspC-antibodies. Our findings on immunogenicity and cross-reactivity suggest that in a future pneumococcal protein based vaccine, only a limited number of proteins could be sufficient.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Streptococcus pneumoniae, antibody response, PspA, PspC
in
Vaccine
volume
25
issue
2
pages
341 - 345
publisher
Elsevier
external identifiers
  • wos:000243614900014
  • scopus:33845226709
ISSN
1873-2518
DOI
10.1016/j.vaccine.2006.07.028
language
English
LU publication?
yes
id
541a218e-7e33-4021-a12b-30969d3e5607 (old id 160849)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16996173&dopt=Abstract
date added to LUP
2007-07-12 13:16:02
date last changed
2017-04-09 03:32:33
@article{541a218e-7e33-4021-a12b-30969d3e5607,
  abstract     = {gG antibodies against pneumococcal surface protein A, family 1 (PspAl) and family 2 (PspA2), protein C (PspC), and protein Hic were investigated in 41 patients with invasive pneumococcal disease. Pre-existing antibody levels against the four pneumococcal proteins were not significantly different from those found in 40 patients with non-pneumococcal bacteremia or 80 healthy controls. However, during convalescense a strong immune response developed especially against PspA, and there was a high degree of cross-reactivity between PspA-and PspC-antibodies. Our findings on immunogenicity and cross-reactivity suggest that in a future pneumococcal protein based vaccine, only a limited number of proteins could be sufficient.},
  author       = {Linder, Adam and Hollingshead, Susan and Janulczyk, Robert and Christensson, Bertil and Åkesson, Per},
  issn         = {1873-2518},
  keyword      = {Streptococcus pneumoniae,antibody response,PspA,PspC},
  language     = {eng},
  number       = {2},
  pages        = {341--345},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Human antibody response towards the pneumococcal surface proteins PspA and PspC during invasive pneumococcal infection.},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2006.07.028},
  volume       = {25},
  year         = {2007},
}