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Magnetic Resonance Spectroscopy in Schizophrenia : Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism

Duarte, João M.N. LU and Xin, Lijing (2019) In Neurochemical Research 44(1). p.102-116
Abstract

In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to healthy subjects are generally interpreted as markers of glutamatergic dysfunction. However, only a small fraction of MRS-detectable glutamate is involved in neurotransmission. Here we review and discuss brain metabolic processes that involve glutamate and that are likely to be implicated in neuropsychiatric disorders.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glutamate, Glutamine, Magnetic resonance, Metabolism, Schizophrenia
in
Neurochemical Research
volume
44
issue
1
pages
15 pages
publisher
Springer
external identifiers
  • scopus:85044760088
ISSN
0364-3190
DOI
10.1007/s11064-018-2521-z
language
English
LU publication?
yes
id
160e88dd-274c-4173-b74e-349bbe27d3a9
date added to LUP
2018-04-10 10:50:18
date last changed
2019-08-14 04:13:57
@article{160e88dd-274c-4173-b74e-349bbe27d3a9,
  abstract     = {<p>In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to healthy subjects are generally interpreted as markers of glutamatergic dysfunction. However, only a small fraction of MRS-detectable glutamate is involved in neurotransmission. Here we review and discuss brain metabolic processes that involve glutamate and that are likely to be implicated in neuropsychiatric disorders.</p>},
  author       = {Duarte, João M.N. and Xin, Lijing},
  issn         = {0364-3190},
  keyword      = {Glutamate,Glutamine,Magnetic resonance,Metabolism,Schizophrenia},
  language     = {eng},
  number       = {1},
  pages        = {102--116},
  publisher    = {Springer},
  series       = {Neurochemical Research},
  title        = {Magnetic Resonance Spectroscopy in Schizophrenia : Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism},
  url          = {http://dx.doi.org/10.1007/s11064-018-2521-z},
  volume       = {44},
  year         = {2019},
}