Magnetic Resonance Spectroscopy in Schizophrenia : Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism
Duarte, João M.N. LU
and Xin, Lijing
(2019)
In Neurochemical Research
44(1).
p.102-116
- Abstract
In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to healthy subjects are generally interpreted as markers of glutamatergic dysfunction. However, only a small fraction of MRS-detectable glutamate is involved in neurotransmission. Here we review and discuss brain metabolic processes that involve glutamate and that are likely to be implicated in neuropsychiatric disorders.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/160e88dd-274c-4173-b74e-349bbe27d3a9
- author
- Duarte, João M.N.
LU
and Xin, Lijing
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Glutamate, Glutamine, Magnetic resonance, Metabolism, Schizophrenia
- in
- Neurochemical Research
- volume
- 44
- issue
- 1
- pages
- 15 pages
- publisher
- Springer
- external identifiers
-
- pmid:29616444
- scopus:85044760088
- ISSN
- 0364-3190
- DOI
- 10.1007/s11064-018-2521-z
- language
- English
- LU publication?
- yes
- id
- 160e88dd-274c-4173-b74e-349bbe27d3a9
- date added to LUP
- 2018-04-10 10:50:18
- date last changed
- 2024-05-13 07:38:06
@article{160e88dd-274c-4173-b74e-349bbe27d3a9,
abstract = {{<p>In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in neuropsychiatric disorders, namely schizophrenia. Alterations of glutamate and glutamine levels in brains of schizophrenia patients relative to healthy subjects are generally interpreted as markers of glutamatergic dysfunction. However, only a small fraction of MRS-detectable glutamate is involved in neurotransmission. Here we review and discuss brain metabolic processes that involve glutamate and that are likely to be implicated in neuropsychiatric disorders.</p>}},
author = {{Duarte, João M.N. and Xin, Lijing}},
issn = {{0364-3190}},
keywords = {{Glutamate; Glutamine; Magnetic resonance; Metabolism; Schizophrenia}},
language = {{eng}},
number = {{1}},
pages = {{102--116}},
publisher = {{Springer}},
series = {{Neurochemical Research}},
title = {{Magnetic Resonance Spectroscopy in Schizophrenia : Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism}},
url = {{http://dx.doi.org/10.1007/s11064-018-2521-z}},
doi = {{10.1007/s11064-018-2521-z}},
volume = {{44}},
year = {{2019}},
}