Advanced

Cell transplantation in Parkinson's disease: problems and perspectives.

Jensen, Laura LU ; Petit, Géraldine LU and Brundin, Patrik LU (2010) In Current Opinion in Neurology 23. p.426-432
Abstract
PURPOSE OF REVIEW: We review recent experiments conducted using embryonic tissue and stem cell transplants in experimental models of Parkinson's disease. We also highlight the challenges which remain to be met in order for cell therapy to become clinically effective and safe. RECENT FINDINGS: The outcome of previous clinical transplantation trials was variable in terms of motor recovery. We discuss whether transplants can mitigate L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias and consider the risk factors which predispose to graft-induced dyskinesias. In addition, we introduce Transeuro, a new European Union-funded multicenter consortium which plans to perform transplantation trials.Stem cells have emerged as an alternative... (More)
PURPOSE OF REVIEW: We review recent experiments conducted using embryonic tissue and stem cell transplants in experimental models of Parkinson's disease. We also highlight the challenges which remain to be met in order for cell therapy to become clinically effective and safe. RECENT FINDINGS: The outcome of previous clinical transplantation trials was variable in terms of motor recovery. We discuss whether transplants can mitigate L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias and consider the risk factors which predispose to graft-induced dyskinesias. In addition, we introduce Transeuro, a new European Union-funded multicenter consortium which plans to perform transplantation trials.Stem cells have emerged as an alternative source for the generation of dopaminergic precursors. We briefly outline progress made in the use of human embryonic stem cells and focus predominantly on the emerging field of induced pluripotency. We conclude by introducing the exciting and novel method of direct reprogramming which involves the conversion of fibroblasts to neurons without inducing a pluripotent state. SUMMARY: The area of cell transplantation has been revitalized by the identification of parameters which predispose patients to graft-induced dyskinesias and by the emergence of novel methods of generating dopaminergic neurons. Hopefully, the Transeuro clinical trials will give further impetus and act as a stepping stone to future trials employing stem-cell-derived neurons. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Neurology
volume
23
pages
426 - 432
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000279653300013
  • pmid:20489615
  • scopus:77954622035
ISSN
1473-6551
DOI
10.1097/WCO.0b013e32833b1f62
language
English
LU publication?
yes
id
b66d4044-2643-460e-9a12-1de1ee12d4d4 (old id 1610057)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20489615?dopt=Abstract
date added to LUP
2010-06-02 11:14:32
date last changed
2018-05-29 10:53:39
@article{b66d4044-2643-460e-9a12-1de1ee12d4d4,
  abstract     = {PURPOSE OF REVIEW: We review recent experiments conducted using embryonic tissue and stem cell transplants in experimental models of Parkinson's disease. We also highlight the challenges which remain to be met in order for cell therapy to become clinically effective and safe. RECENT FINDINGS: The outcome of previous clinical transplantation trials was variable in terms of motor recovery. We discuss whether transplants can mitigate L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias and consider the risk factors which predispose to graft-induced dyskinesias. In addition, we introduce Transeuro, a new European Union-funded multicenter consortium which plans to perform transplantation trials.Stem cells have emerged as an alternative source for the generation of dopaminergic precursors. We briefly outline progress made in the use of human embryonic stem cells and focus predominantly on the emerging field of induced pluripotency. We conclude by introducing the exciting and novel method of direct reprogramming which involves the conversion of fibroblasts to neurons without inducing a pluripotent state. SUMMARY: The area of cell transplantation has been revitalized by the identification of parameters which predispose patients to graft-induced dyskinesias and by the emergence of novel methods of generating dopaminergic neurons. Hopefully, the Transeuro clinical trials will give further impetus and act as a stepping stone to future trials employing stem-cell-derived neurons.},
  author       = {Jensen, Laura and Petit, Géraldine and Brundin, Patrik},
  issn         = {1473-6551},
  language     = {eng},
  pages        = {426--432},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Neurology},
  title        = {Cell transplantation in Parkinson's disease: problems and perspectives.},
  url          = {http://dx.doi.org/10.1097/WCO.0b013e32833b1f62},
  volume       = {23},
  year         = {2010},
}