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Micro- and macromechanical effects on the wound bed of negative pressure wound therapy using gauze and foam.

Borgquist, Ola LU ; Gustafsson, Lotta LU ; Ingemansson, Richard LU and Malmsjö, Malin LU (2010) In Annals of Plastic Surgery 64(6). p.789-793
Abstract
Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a signaling cascade which ultimately leads to wound healing. The aim of the present study was to examine the effect of gauze and foam on macro- and microdeformation during treatment with negative pressure. An in vivo porcine peripheral wound model was used. NPWT was applied for 72 hours at 0, -75, and -125 mm Hg, using either foam or gauze as wound filler. The mechanical effects of NPWT were examined by... (More)
Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a signaling cascade which ultimately leads to wound healing. The aim of the present study was to examine the effect of gauze and foam on macro- and microdeformation during treatment with negative pressure. An in vivo porcine peripheral wound model was used. NPWT was applied for 72 hours at 0, -75, and -125 mm Hg, using either foam or gauze as wound filler. The mechanical effects of NPWT were examined by measuring the wound surface area reduction and by histologic analysis of the wound bed tissue. Similar degrees of wound contraction (macrodeformation) were seen during NPWT regardless if foam or gauze was used. After negative pressure had been discontinued, the wound stayed contracted. There was no difference in wound contraction between -75 and -125 mm Hg. Biopsies of the wound bed revealed a repeating pattern of wound surface undulations and small tissue blebs ("tissue mushrooms") were pulled into the pores of the foam dressing and the spaces between the threads in the gauze dressing (microdeformation). This pattern was obvious in wounds treated both with foam and gauze, at atmospheric pressure (0 mm Hg) as well as at subatmospheric pressures (-75 and -125 mm Hg). The degrees of micro- and macrodeformation of the wound bed are similar after NPWT regardless if foam or gauze is used as wound filler. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Plastic Surgery
volume
64
issue
6
pages
789 - 793
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000278116900021
  • pmid:20489409
  • scopus:77952881739
ISSN
1536-3708
DOI
10.1097/SAP.0b013e3181ba578a
language
English
LU publication?
yes
id
111c3d00-011d-4458-b0d7-7f1046f518db (old id 1610063)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20489409?dopt=Abstract
date added to LUP
2010-06-02 11:16:16
date last changed
2018-06-03 04:30:55
@article{111c3d00-011d-4458-b0d7-7f1046f518db,
  abstract     = {Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a signaling cascade which ultimately leads to wound healing. The aim of the present study was to examine the effect of gauze and foam on macro- and microdeformation during treatment with negative pressure. An in vivo porcine peripheral wound model was used. NPWT was applied for 72 hours at 0, -75, and -125 mm Hg, using either foam or gauze as wound filler. The mechanical effects of NPWT were examined by measuring the wound surface area reduction and by histologic analysis of the wound bed tissue. Similar degrees of wound contraction (macrodeformation) were seen during NPWT regardless if foam or gauze was used. After negative pressure had been discontinued, the wound stayed contracted. There was no difference in wound contraction between -75 and -125 mm Hg. Biopsies of the wound bed revealed a repeating pattern of wound surface undulations and small tissue blebs ("tissue mushrooms") were pulled into the pores of the foam dressing and the spaces between the threads in the gauze dressing (microdeformation). This pattern was obvious in wounds treated both with foam and gauze, at atmospheric pressure (0 mm Hg) as well as at subatmospheric pressures (-75 and -125 mm Hg). The degrees of micro- and macrodeformation of the wound bed are similar after NPWT regardless if foam or gauze is used as wound filler.},
  author       = {Borgquist, Ola and Gustafsson, Lotta and Ingemansson, Richard and Malmsjö, Malin},
  issn         = {1536-3708},
  language     = {eng},
  number       = {6},
  pages        = {789--793},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Annals of Plastic Surgery},
  title        = {Micro- and macromechanical effects on the wound bed of negative pressure wound therapy using gauze and foam.},
  url          = {http://dx.doi.org/10.1097/SAP.0b013e3181ba578a},
  volume       = {64},
  year         = {2010},
}