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Pre-Diagnostic Levels of Anionic Trypsinogen, Cationic Trypsinogen, and Pancreatic Secretory Trypsin Inhibitor in Relation to Pancreatic Cancer Risk.

Johansen, Dorthe LU ; Manjer, Jonas LU ; Regnér, Sara LU and Lindkvist, Björn LU (2010) In Pancreatology 10(2-3). p.229-237
Abstract
Background/Aims: Experimental studies have suggested that trypsinogen may enhance tumor progression and that the ratio between anionic trypsinogen and cationic trypsinogen (HAT/HCT) and between the sum of trypsinogens and pancreatic secretory trypsin inhibitor (PSTI) ((HAT + HCT)/PSTI) are disturbed in patients with pancreatic cancer. The aim of this study was to investigate if pre-diagnostic levels of these parameters are associated with subsequent pancreatic cancer risk. Methods: A total of 33,346 subjects participated in a health screening programme in Malmö, Sweden. Pancreatic cancer cases (n = 84) were matched to three controls each. HAT, HCT and PSTI were analyzed in pre-diagnostic serum samples. Odds ratios for pancreatic cancer... (More)
Background/Aims: Experimental studies have suggested that trypsinogen may enhance tumor progression and that the ratio between anionic trypsinogen and cationic trypsinogen (HAT/HCT) and between the sum of trypsinogens and pancreatic secretory trypsin inhibitor (PSTI) ((HAT + HCT)/PSTI) are disturbed in patients with pancreatic cancer. The aim of this study was to investigate if pre-diagnostic levels of these parameters are associated with subsequent pancreatic cancer risk. Methods: A total of 33,346 subjects participated in a health screening programme in Malmö, Sweden. Pancreatic cancer cases (n = 84) were matched to three controls each. HAT, HCT and PSTI were analyzed in pre-diagnostic serum samples. Odds ratios for pancreatic cancer were calculated using logistic regression and were then stratified for other risk factors. Results: In the main analysis, a statistically significant association between the ratio between HAT/HCT and pancreatic cancer was observed for all, for the crude OR and for the ORs adjusted for sex, BMI or Helicobacter pylori. When stratified for sex, statistically significant associations were found for females in the crude OR and for the ORs adjusted for time to analysis, BMI, alcohol consumption or H. pylori. There was a positive association between the ratio of HAT/HCT to pancreatic cancer in the intermediate/high alcohol consumption group and subjects with a BMI <25. The sum of trypsinogens showed a similar pattern, but was only of borderline significance in the intermediate/high alcohol consumption group. Conclusion: Our hypothesis predicted an increased risk for pancreatic cancer related to an imbalance between trypsin activity and trypsin inhibition capacity. The findings concerning the ratio of HAT/HCT are in line with this. The results related to analyses stratified for other risk factors should be considered as mainly explorative. and IAP. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pancreatology
volume
10
issue
2-3
pages
229 - 237
publisher
Karger
external identifiers
  • wos:000279583200018
  • pmid:20484960
  • scopus:77952303590
ISSN
1424-3903
DOI
10.1159/000243732
language
English
LU publication?
yes
id
45b2c9f0-5d87-4fd1-b184-748982672bf6 (old id 1610105)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20484960?dopt=Abstract
date added to LUP
2010-06-02 10:47:57
date last changed
2018-05-29 11:39:28
@article{45b2c9f0-5d87-4fd1-b184-748982672bf6,
  abstract     = {Background/Aims: Experimental studies have suggested that trypsinogen may enhance tumor progression and that the ratio between anionic trypsinogen and cationic trypsinogen (HAT/HCT) and between the sum of trypsinogens and pancreatic secretory trypsin inhibitor (PSTI) ((HAT + HCT)/PSTI) are disturbed in patients with pancreatic cancer. The aim of this study was to investigate if pre-diagnostic levels of these parameters are associated with subsequent pancreatic cancer risk. Methods: A total of 33,346 subjects participated in a health screening programme in Malmö, Sweden. Pancreatic cancer cases (n = 84) were matched to three controls each. HAT, HCT and PSTI were analyzed in pre-diagnostic serum samples. Odds ratios for pancreatic cancer were calculated using logistic regression and were then stratified for other risk factors. Results: In the main analysis, a statistically significant association between the ratio between HAT/HCT and pancreatic cancer was observed for all, for the crude OR and for the ORs adjusted for sex, BMI or Helicobacter pylori. When stratified for sex, statistically significant associations were found for females in the crude OR and for the ORs adjusted for time to analysis, BMI, alcohol consumption or H. pylori. There was a positive association between the ratio of HAT/HCT to pancreatic cancer in the intermediate/high alcohol consumption group and subjects with a BMI &lt;25. The sum of trypsinogens showed a similar pattern, but was only of borderline significance in the intermediate/high alcohol consumption group. Conclusion: Our hypothesis predicted an increased risk for pancreatic cancer related to an imbalance between trypsin activity and trypsin inhibition capacity. The findings concerning the ratio of HAT/HCT are in line with this. The results related to analyses stratified for other risk factors should be considered as mainly explorative. and IAP.},
  author       = {Johansen, Dorthe and Manjer, Jonas and Regnér, Sara and Lindkvist, Björn},
  issn         = {1424-3903},
  language     = {eng},
  number       = {2-3},
  pages        = {229--237},
  publisher    = {Karger},
  series       = {Pancreatology},
  title        = {Pre-Diagnostic Levels of Anionic Trypsinogen, Cationic Trypsinogen, and Pancreatic Secretory Trypsin Inhibitor in Relation to Pancreatic Cancer Risk.},
  url          = {http://dx.doi.org/10.1159/000243732},
  volume       = {10},
  year         = {2010},
}