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Quality of Life in Adults Operated On for Hirschsprung Disease in Childhood.

Gunnarsdottir, Anna LU ; Sandblom, Gabriel LU ; Arnbjörnsson, Einar LU and Larsson, Lars Torsten LU (2010) In Journal of Pediatric Gastroenterology and Nutrition - Jpgn 51. p.160-166
Abstract
OBJECTIVES:: The aim of this study is to explore the long-term quality of life (QoL) in adults after surgery for Hirschsprung disease in childhood. PATIENTS AND METHODS:: Altogether 51 patients were operated for HD at our center during the period 1969 to 1989. In 2007, the validated instruments for assessing QoL, the SF-36 health survey and the Gastrointestinal Quality of Life Index (GIQLI), were sent to the 47 patients still alive at the time of the study. A retrospective review of the patient records was also done. RESULTS:: Forty-two patients returned both questionnaires (89% response rate) at the median age of 28.5 (range 18-45) years. The median clinical follow-up time was 5.7 years (range 5 months-23 years). At the last clinical... (More)
OBJECTIVES:: The aim of this study is to explore the long-term quality of life (QoL) in adults after surgery for Hirschsprung disease in childhood. PATIENTS AND METHODS:: Altogether 51 patients were operated for HD at our center during the period 1969 to 1989. In 2007, the validated instruments for assessing QoL, the SF-36 health survey and the Gastrointestinal Quality of Life Index (GIQLI), were sent to the 47 patients still alive at the time of the study. A retrospective review of the patient records was also done. RESULTS:: Forty-two patients returned both questionnaires (89% response rate) at the median age of 28.5 (range 18-45) years. The median clinical follow-up time was 5.7 years (range 5 months-23 years). At the last clinical control, 4 (9%) patients had a terminal enterostomy, 12 (29%) had soiling, 5 (12%) had constipation, and 2 (5%) experienced recurrent enterocolitis. In contrast to males, the subscores for females were lower for general health and mental health than for an age- and sex-matched general population (P < 0.05). Patients having aganglionosis to the right colon had lower GIQLI scores than those with aganglionosis to the left colon (P < 0.05). In multivariate linear regression analysis, female sex was the only factor associated with lower GIQLI score (P < 0.05). CONCLUSIONS:: The long-term QoL of adults operated for Hirschsprung disease in their youth is satisfactory. Female scores were lower for general and mental health, compared with the matched control group. The study indicates that the longer the aganglionic segment, the greater its impact on QoL in later life. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Journal of Pediatric Gastroenterology and Nutrition - Jpgn
volume
51
pages
160 - 166
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000280338600009
  • pmid:20453676
  • scopus:77955228681
ISSN
1536-4801
DOI
10.1097/MPG.0b013e3181cac1b6
language
English
LU publication?
yes
id
9b84223d-abbf-4b20-88e6-d46f7f8e07ff (old id 1610443)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20453676?dopt=Abstract
date added to LUP
2010-06-01 20:52:15
date last changed
2018-05-29 10:22:13
@article{9b84223d-abbf-4b20-88e6-d46f7f8e07ff,
  abstract     = {OBJECTIVES:: The aim of this study is to explore the long-term quality of life (QoL) in adults after surgery for Hirschsprung disease in childhood. PATIENTS AND METHODS:: Altogether 51 patients were operated for HD at our center during the period 1969 to 1989. In 2007, the validated instruments for assessing QoL, the SF-36 health survey and the Gastrointestinal Quality of Life Index (GIQLI), were sent to the 47 patients still alive at the time of the study. A retrospective review of the patient records was also done. RESULTS:: Forty-two patients returned both questionnaires (89% response rate) at the median age of 28.5 (range 18-45) years. The median clinical follow-up time was 5.7 years (range 5 months-23 years). At the last clinical control, 4 (9%) patients had a terminal enterostomy, 12 (29%) had soiling, 5 (12%) had constipation, and 2 (5%) experienced recurrent enterocolitis. In contrast to males, the subscores for females were lower for general health and mental health than for an age- and sex-matched general population (P &lt; 0.05). Patients having aganglionosis to the right colon had lower GIQLI scores than those with aganglionosis to the left colon (P &lt; 0.05). In multivariate linear regression analysis, female sex was the only factor associated with lower GIQLI score (P &lt; 0.05). CONCLUSIONS:: The long-term QoL of adults operated for Hirschsprung disease in their youth is satisfactory. Female scores were lower for general and mental health, compared with the matched control group. The study indicates that the longer the aganglionic segment, the greater its impact on QoL in later life.},
  author       = {Gunnarsdottir, Anna and Sandblom, Gabriel and Arnbjörnsson, Einar and Larsson, Lars Torsten},
  issn         = {1536-4801},
  language     = {eng},
  pages        = {160--166},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Pediatric Gastroenterology and Nutrition - Jpgn},
  title        = {Quality of Life in Adults Operated On for Hirschsprung Disease in Childhood.},
  url          = {http://dx.doi.org/10.1097/MPG.0b013e3181cac1b6},
  volume       = {51},
  year         = {2010},
}