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Regulatory T cells and the control of modified lipoprotein autoimmunity-driven atherosclerosis.

Nilsson, Jan LU ; Wigren, Maria LU and Shah, Prediman K (2009) In Trends in Cardiovascular Medicine 19(8). p.272-276
Abstract
It has long been recognized that arterial inflammation plays a key role in the development of atherosclerosis. More recent evidence has suggested that this inflammation is modulated by autoimmune responses against modified self-antigens, such as oxidized low-density lipoprotein, in the vascular wall. However, the role of the immune system in atherosclerosis appears to be more complex than in classic autoimmune diseases; and a number of protective immune responses have also been identified. One of the most important of these is carried out by the regulatory T cells. Regulatory T cells inhibit the development of autoimmunity by controlling the activity of autoreactive T cells. If the function of regulatory T cells is compromised in... (More)
It has long been recognized that arterial inflammation plays a key role in the development of atherosclerosis. More recent evidence has suggested that this inflammation is modulated by autoimmune responses against modified self-antigens, such as oxidized low-density lipoprotein, in the vascular wall. However, the role of the immune system in atherosclerosis appears to be more complex than in classic autoimmune diseases; and a number of protective immune responses have also been identified. One of the most important of these is carried out by the regulatory T cells. Regulatory T cells inhibit the development of autoimmunity by controlling the activity of autoreactive T cells. If the function of regulatory T cells is compromised in hypercholesterolemic mouse models of atherosclerosis, the development of disease becomes much more aggressive. In this review, we will discuss the possibility that the inflammatory activity in atherosclerotic lesions depends on the balance between plaque antigen-specific proinflammatory Th1-type T cells and anti-inflammatory regulatory T cells specific for the same antigen. We will also discuss the role of hypercholesterolemia in generation of these modified self-antigens as well as ongoing research aiming to develop novel immune-modulating therapy for prevention of cardiovascular disease by targeting these processes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Cardiovascular Medicine
volume
19
issue
8
pages
272 - 276
publisher
Elsevier
external identifiers
  • wos:000277698500006
  • pmid:20447570
  • scopus:77952527041
ISSN
1873-2615
DOI
10.1016/j.tcm.2010.02.010
language
English
LU publication?
yes
id
e80955ee-ee03-4cb9-95ad-63bc6de98d62 (old id 1610553)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20447570?dopt=Abstract
date added to LUP
2010-06-01 20:47:12
date last changed
2017-10-01 04:55:34
@article{e80955ee-ee03-4cb9-95ad-63bc6de98d62,
  abstract     = {It has long been recognized that arterial inflammation plays a key role in the development of atherosclerosis. More recent evidence has suggested that this inflammation is modulated by autoimmune responses against modified self-antigens, such as oxidized low-density lipoprotein, in the vascular wall. However, the role of the immune system in atherosclerosis appears to be more complex than in classic autoimmune diseases; and a number of protective immune responses have also been identified. One of the most important of these is carried out by the regulatory T cells. Regulatory T cells inhibit the development of autoimmunity by controlling the activity of autoreactive T cells. If the function of regulatory T cells is compromised in hypercholesterolemic mouse models of atherosclerosis, the development of disease becomes much more aggressive. In this review, we will discuss the possibility that the inflammatory activity in atherosclerotic lesions depends on the balance between plaque antigen-specific proinflammatory Th1-type T cells and anti-inflammatory regulatory T cells specific for the same antigen. We will also discuss the role of hypercholesterolemia in generation of these modified self-antigens as well as ongoing research aiming to develop novel immune-modulating therapy for prevention of cardiovascular disease by targeting these processes.},
  author       = {Nilsson, Jan and Wigren, Maria and Shah, Prediman K},
  issn         = {1873-2615},
  language     = {eng},
  number       = {8},
  pages        = {272--276},
  publisher    = {Elsevier},
  series       = {Trends in Cardiovascular Medicine},
  title        = {Regulatory T cells and the control of modified lipoprotein autoimmunity-driven atherosclerosis.},
  url          = {http://dx.doi.org/10.1016/j.tcm.2010.02.010},
  volume       = {19},
  year         = {2009},
}