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CGRP receptor antagonism and migraine.

Edvinsson, Lars LU and Ho, Tony W (2010) In Neurotherapeutics 7(2). p.164-175
Abstract
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric nervous system. In the CNS there is a wide distribution of CGRP-containing neurons, with the highest levels occurring in striatum, amygdala, colliculi, and cerebellum. The peripheral projections are involved in neurogenic vasodilatation and inflammation, and central release induces hyperalgesia. CGRP is released from trigeminal nerves in migraine. Trigeminal nerve activation results in... (More)
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric nervous system. In the CNS there is a wide distribution of CGRP-containing neurons, with the highest levels occurring in striatum, amygdala, colliculi, and cerebellum. The peripheral projections are involved in neurogenic vasodilatation and inflammation, and central release induces hyperalgesia. CGRP is released from trigeminal nerves in migraine. Trigeminal nerve activation results in antidromic release of CGRP to cause non-endothelium-mediated vasodilatation. At the central synapses in the trigeminal nucleus caudalis, CGRP acts postjunctionally on second-order neurons to transmit pain signals centrally via the brainstem and midbrain to the thalamus and higher cortical pain regions. Recently developed CGRP receptor antagonists are effective at aborting acute migraine attacks. They may act both centrally and peripherally to attenuate signaling within the trigeminovascular pathway. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurotherapeutics
volume
7
issue
2
pages
164 - 175
publisher
Springer
external identifiers
  • wos:000277082300004
  • pmid:20430315
  • scopus:77953264523
ISSN
1878-7479
DOI
10.1016/j.nurt.2010.02.004
language
English
LU publication?
yes
id
58b4026a-e29b-4819-86c4-f864a0cbbf62 (old id 1610722)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20430315?dopt=Abstract
date added to LUP
2010-06-01 08:46:35
date last changed
2018-05-29 12:22:07
@article{58b4026a-e29b-4819-86c4-f864a0cbbf62,
  abstract     = {Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric nervous system. In the CNS there is a wide distribution of CGRP-containing neurons, with the highest levels occurring in striatum, amygdala, colliculi, and cerebellum. The peripheral projections are involved in neurogenic vasodilatation and inflammation, and central release induces hyperalgesia. CGRP is released from trigeminal nerves in migraine. Trigeminal nerve activation results in antidromic release of CGRP to cause non-endothelium-mediated vasodilatation. At the central synapses in the trigeminal nucleus caudalis, CGRP acts postjunctionally on second-order neurons to transmit pain signals centrally via the brainstem and midbrain to the thalamus and higher cortical pain regions. Recently developed CGRP receptor antagonists are effective at aborting acute migraine attacks. They may act both centrally and peripherally to attenuate signaling within the trigeminovascular pathway.},
  author       = {Edvinsson, Lars and Ho, Tony W},
  issn         = {1878-7479},
  language     = {eng},
  number       = {2},
  pages        = {164--175},
  publisher    = {Springer},
  series       = {Neurotherapeutics},
  title        = {CGRP receptor antagonism and migraine.},
  url          = {http://dx.doi.org/10.1016/j.nurt.2010.02.004},
  volume       = {7},
  year         = {2010},
}