Working memory training decreases hippocampal neurogenesis.
(2006) In Neuroscience 142(3). p.609-613- Abstract
- The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a... (More)
- The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a well-established negative regulator of hippocampal neurogenesis. We found that maze training in general, and a working memory task in particular, increased levels of circulating corticosterone after 4 days of training. Our study indicates that working memory training over a prolonged period of time reduces neurogenesis, and this reduction may partially be mediated by increased stress. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/161116
- author
- Mohapel, Paul LU ; Orre, Karin LU ; Brundin, Patrik LU and Frielingsdorf, Helena LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- corticosterone, reference memory, BrdU, Morris water maze, working memory
- in
- Neuroscience
- volume
- 142
- issue
- 3
- pages
- 609 - 613
- publisher
- Elsevier
- external identifiers
-
- wos:000241530600001
- scopus:33749244443
- pmid:16962715
- ISSN
- 1873-7544
- DOI
- 10.1016/j.neuroscience.2006.07.033
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Molecular Psychiatry Unit (013024100), Wallenberg Neuroscience Centre, Lund (0131000110)
- id
- bbf4f79d-5530-4f50-bab2-9b3334f57d6f (old id 161116)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16962715&dopt=Abstract
- date added to LUP
- 2016-04-01 11:47:24
- date last changed
- 2022-02-18 05:24:46
@article{bbf4f79d-5530-4f50-bab2-9b3334f57d6f,
abstract = {{The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a well-established negative regulator of hippocampal neurogenesis. We found that maze training in general, and a working memory task in particular, increased levels of circulating corticosterone after 4 days of training. Our study indicates that working memory training over a prolonged period of time reduces neurogenesis, and this reduction may partially be mediated by increased stress.}},
author = {{Mohapel, Paul and Orre, Karin and Brundin, Patrik and Frielingsdorf, Helena}},
issn = {{1873-7544}},
keywords = {{corticosterone; reference memory; BrdU; Morris water maze; working memory}},
language = {{eng}},
number = {{3}},
pages = {{609--613}},
publisher = {{Elsevier}},
series = {{Neuroscience}},
title = {{Working memory training decreases hippocampal neurogenesis.}},
url = {{http://dx.doi.org/10.1016/j.neuroscience.2006.07.033}},
doi = {{10.1016/j.neuroscience.2006.07.033}},
volume = {{142}},
year = {{2006}},
}