Post- versus presynaptic plasticity in L-DOPA-induced dyskinesia.
(2006) In Journal of Neurochemistry 99(2). p.381-392- Abstract
- L-3,4-dihydroxyphenylalanine (L-DOPA) remains the most efficacious drug for the treatment of Parkinson's disease (PD), but causes adverse effects that limit its utility. L-DOPA-induced dyskinesia (abnormal involuntary movements) is a significant clinical problem that attracts growing scientific interest. Current notions attribute the development of dyskinesia to two main factors, viz. the loss of nigrostriatal dopamine (DA) projections and the maladaptive changes produced by L-DOPA at sites postsynaptic to the nigrostriatal neuron. Basic research in the past 15 years has placed a lot of emphasis on the postsynaptic plasticity associated with dyskinesia, but recent experimental work shows that also some presynaptic factors, involving the... (More)
- L-3,4-dihydroxyphenylalanine (L-DOPA) remains the most efficacious drug for the treatment of Parkinson's disease (PD), but causes adverse effects that limit its utility. L-DOPA-induced dyskinesia (abnormal involuntary movements) is a significant clinical problem that attracts growing scientific interest. Current notions attribute the development of dyskinesia to two main factors, viz. the loss of nigrostriatal dopamine (DA) projections and the maladaptive changes produced by L-DOPA at sites postsynaptic to the nigrostriatal neuron. Basic research in the past 15 years has placed a lot of emphasis on the postsynaptic plasticity associated with dyskinesia, but recent experimental work shows that also some presynaptic factors, involving the regulation of L-DOPA/DA release and metabolism in the brain, may show plasticity during treatment. This review summarizes significant studies of L-DOPA-induced dyskinesia in patients and animal models, and outlines directions for future experiments addressing mechanisms of presynaptic plasticity. These investigations may uncover clues to the varying susceptibility to L-DOPA-induced dyskinesia among PD patients, paving the way for tailor-made treatments. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/161359
- author
- Cenci Nilsson, Angela LU and Lundblad, Martin LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neurochemistry
- volume
- 99
- issue
- 2
- pages
- 381 - 392
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000240834200003
- scopus:33748677017
- ISSN
- 1471-4159
- DOI
- 10.1111/j.1471-4159.2006.04124.x
- language
- English
- LU publication?
- yes
- id
- 640af9fb-303a-43d3-a09f-de4110ea454e (old id 161359)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16942598&dopt=Abstract
- date added to LUP
- 2016-04-01 16:51:44
- date last changed
- 2022-04-23 01:00:27
@article{640af9fb-303a-43d3-a09f-de4110ea454e, abstract = {{L-3,4-dihydroxyphenylalanine (L-DOPA) remains the most efficacious drug for the treatment of Parkinson's disease (PD), but causes adverse effects that limit its utility. L-DOPA-induced dyskinesia (abnormal involuntary movements) is a significant clinical problem that attracts growing scientific interest. Current notions attribute the development of dyskinesia to two main factors, viz. the loss of nigrostriatal dopamine (DA) projections and the maladaptive changes produced by L-DOPA at sites postsynaptic to the nigrostriatal neuron. Basic research in the past 15 years has placed a lot of emphasis on the postsynaptic plasticity associated with dyskinesia, but recent experimental work shows that also some presynaptic factors, involving the regulation of L-DOPA/DA release and metabolism in the brain, may show plasticity during treatment. This review summarizes significant studies of L-DOPA-induced dyskinesia in patients and animal models, and outlines directions for future experiments addressing mechanisms of presynaptic plasticity. These investigations may uncover clues to the varying susceptibility to L-DOPA-induced dyskinesia among PD patients, paving the way for tailor-made treatments.}}, author = {{Cenci Nilsson, Angela and Lundblad, Martin}}, issn = {{1471-4159}}, language = {{eng}}, number = {{2}}, pages = {{381--392}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Neurochemistry}}, title = {{Post- versus presynaptic plasticity in L-DOPA-induced dyskinesia.}}, url = {{https://lup.lub.lu.se/search/files/4802202/625597.pdf}}, doi = {{10.1111/j.1471-4159.2006.04124.x}}, volume = {{99}}, year = {{2006}}, }