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Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer’s Disease Detection and Dementia Risk Reduction : The AD-RIDDLE Project

Malzbender, K. ; Barbarino, P. ; Ferrell, P. Barkman ; Bradshaw, A. ; Brookes, A. J. ; Díaz, C. ; van der Flier, W. M. ; Georges, J. ; Hansson, O. LU orcid and Hartmanis, M. , et al. (2024) In Journal of Prevention of Alzheimer's Disease
Abstract

The Real-World Implementation, Deployment, and Validation of Early Detection Tools and Lifestyle Enhancement (AD-RIDDLE) project, recently launched with the support of the EU Innovative Health Initiative (IHI) public-private partnership and UK Research and Innovation (UKRI), aims to develop, test, and deploy a modular toolbox platform that can reduce existing barriers to the timely detection, and therapeutic approaches in Alzheimer’s disease (AD), thus accelerating AD innovation. By focusing on health system and health worker practices, AD-RIDDLE seeks to improve and smooth AD management at and between each key step of the clinical pathway and across the disease continuum, from at-risk asymptomatic stages to early symptomatic ones. This... (More)

The Real-World Implementation, Deployment, and Validation of Early Detection Tools and Lifestyle Enhancement (AD-RIDDLE) project, recently launched with the support of the EU Innovative Health Initiative (IHI) public-private partnership and UK Research and Innovation (UKRI), aims to develop, test, and deploy a modular toolbox platform that can reduce existing barriers to the timely detection, and therapeutic approaches in Alzheimer’s disease (AD), thus accelerating AD innovation. By focusing on health system and health worker practices, AD-RIDDLE seeks to improve and smooth AD management at and between each key step of the clinical pathway and across the disease continuum, from at-risk asymptomatic stages to early symptomatic ones. This includes innovation and improvement in AD awareness, risk reduction and prevention, detection, diagnosis, and intervention. The 24 partners in the AD-RIDDLE interdisciplinary consortium will develop and test the AD-RIDDLE toolbox platform and its components individually and in combination in six European countries. Expected results from this cross-sectoral research collaboration include tools for earlier detection and accurate diagnosis; validated, novel digital cognitive and blood-based biomarkers; and improved access to individualized preventative interventions (including multimodal interventions and symptomatic/disease-modifying therapies) across diverse populations, within the framework of precision medicine. Overall, AD-RIDDLE toolbox platform will advance management of AD, improving outcomes for patients and their families, and reducing costs.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Alzheimer’s disease, biomarkers, dementia, implementation, precision medicine, real world data
in
Journal of Prevention of Alzheimer's Disease
publisher
Springer
external identifiers
  • pmid:38374739
  • scopus:85183436163
ISSN
2274-5807
DOI
10.14283/jpad.2024.32
language
English
LU publication?
yes
id
16164182-fe73-43d0-9651-1b1fd3c2d184
date added to LUP
2024-02-20 12:21:46
date last changed
2024-04-20 11:35:15
@article{16164182-fe73-43d0-9651-1b1fd3c2d184,
  abstract     = {{<p>The Real-World Implementation, Deployment, and Validation of Early Detection Tools and Lifestyle Enhancement (AD-RIDDLE) project, recently launched with the support of the EU Innovative Health Initiative (IHI) public-private partnership and UK Research and Innovation (UKRI), aims to develop, test, and deploy a modular toolbox platform that can reduce existing barriers to the timely detection, and therapeutic approaches in Alzheimer’s disease (AD), thus accelerating AD innovation. By focusing on health system and health worker practices, AD-RIDDLE seeks to improve and smooth AD management at and between each key step of the clinical pathway and across the disease continuum, from at-risk asymptomatic stages to early symptomatic ones. This includes innovation and improvement in AD awareness, risk reduction and prevention, detection, diagnosis, and intervention. The 24 partners in the AD-RIDDLE interdisciplinary consortium will develop and test the AD-RIDDLE toolbox platform and its components individually and in combination in six European countries. Expected results from this cross-sectoral research collaboration include tools for earlier detection and accurate diagnosis; validated, novel digital cognitive and blood-based biomarkers; and improved access to individualized preventative interventions (including multimodal interventions and symptomatic/disease-modifying therapies) across diverse populations, within the framework of precision medicine. Overall, AD-RIDDLE toolbox platform will advance management of AD, improving outcomes for patients and their families, and reducing costs.</p>}},
  author       = {{Malzbender, K. and Barbarino, P. and Ferrell, P. Barkman and Bradshaw, A. and Brookes, A. J. and Díaz, C. and van der Flier, W. M. and Georges, J. and Hansson, O. and Hartmanis, M. and Jönsson, L. and Krishnan, R. and MacLeod, T. and Mangialasche, F. and Mecocci, P. and Minguillon, C. and Middleton, L. and Pla, S. and Sardi, S. P. and Schöll, M. and Suárez-Calvet, M. and Weidner, W. and Visser, P. J. and Zetterberg, H. and Bose, N. and Solomon, A. and Kivipelto, Miia}},
  issn         = {{2274-5807}},
  keywords     = {{Alzheimer’s disease; biomarkers; dementia; implementation; precision medicine; real world data}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Journal of Prevention of Alzheimer's Disease}},
  title        = {{Validation, Deployment, and Real-World Implementation of a Modular Toolbox for Alzheimer’s Disease Detection and Dementia Risk Reduction : The AD-RIDDLE Project}},
  url          = {{http://dx.doi.org/10.14283/jpad.2024.32}},
  doi          = {{10.14283/jpad.2024.32}},
  year         = {{2024}},
}