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Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats

Cudalbu, Cristina ; Comment, Arnaud ; Kurdzesau, Fiodar ; van Heeswijk, Ruud B. ; Uffmann, Kai ; Jannin, Sami ; Denisov, Vladimir LU ; Kirik, Deniz LU orcid and Gruetter, Rolf (2010) In Physical Chemistry Chemical Physics 12(22). p.5818-5823
Abstract
The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized N-15 labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized N-15 labeled choline in live animals.
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physical Chemistry Chemical Physics
volume
12
issue
22
pages
5818 - 5823
publisher
Royal Society of Chemistry
external identifiers
  • wos:000278098900012
  • scopus:77952914139
  • pmid:20461252
ISSN
1463-9084
DOI
10.1039/c002309b
language
English
LU publication?
yes
id
8f853861-845a-4675-b39d-99e197f18abb (old id 1616675)
date added to LUP
2016-04-01 14:16:44
date last changed
2025-02-14 01:54:21
@article{8f853861-845a-4675-b39d-99e197f18abb,
  abstract     = {{The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized N-15 labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized N-15 labeled choline in live animals.}},
  author       = {{Cudalbu, Cristina and Comment, Arnaud and Kurdzesau, Fiodar and van Heeswijk, Ruud B. and Uffmann, Kai and Jannin, Sami and Denisov, Vladimir and Kirik, Deniz and Gruetter, Rolf}},
  issn         = {{1463-9084}},
  language     = {{eng}},
  number       = {{22}},
  pages        = {{5818--5823}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Physical Chemistry Chemical Physics}},
  title        = {{Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats}},
  url          = {{http://dx.doi.org/10.1039/c002309b}},
  doi          = {{10.1039/c002309b}},
  volume       = {{12}},
  year         = {{2010}},
}