Advanced

Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid beta Protein Fibrillation

Cabaleiro-Lago, Celia; Quinlan-Pluck, Fiona; Lynch, Iseult; Dawson, Kenneth A. and Linse, Sara LU (2010) In ACS Chemical Neuroscience 1(4). p.279-287
Abstract
The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the... (More)
The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the interplay between these two pathways, and the predominance of one mechanism over the other will be determined by the relative equilibrium and rate constants. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amyloid, aggregation kinetics, nanoparticles
in
ACS Chemical Neuroscience
volume
1
issue
4
pages
279 - 287
publisher
The American Chemical Society
external identifiers
  • wos:000277981200005
  • scopus:77951681963
ISSN
1948-7193
DOI
10.1021/cn900027u
language
English
LU publication?
yes
id
bc27f325-840b-4f15-8b5b-9fdc1b7620f8 (old id 1617167)
date added to LUP
2010-06-23 11:34:16
date last changed
2018-05-29 10:37:11
@article{bc27f325-840b-4f15-8b5b-9fdc1b7620f8,
  abstract     = {The fibrillation kinetics of the amyloid beta peptide is analyzed in presence of cationic polystyrene nanoparticles of different size. The results highlight the importance of the ratio between the peptide and particle concentration. Depending on the specific ratio, the kinetic effects vary from acceleration of the fibrillation process by reducing the lag phase at low particle surface area in solution to inhibition of the fibrillation process at high particle surface area. The kinetic behavior can be explained if we assume a balance between two different pathways: first fibrillation of free monomer in solution and second nucleation and fibrillation promoted at the particle surface. The overall rate of fibrillation will depend on the interplay between these two pathways, and the predominance of one mechanism over the other will be determined by the relative equilibrium and rate constants.},
  author       = {Cabaleiro-Lago, Celia and Quinlan-Pluck, Fiona and Lynch, Iseult and Dawson, Kenneth A. and Linse, Sara},
  issn         = {1948-7193},
  keyword      = {Amyloid,aggregation kinetics,nanoparticles},
  language     = {eng},
  number       = {4},
  pages        = {279--287},
  publisher    = {The American Chemical Society},
  series       = {ACS Chemical Neuroscience},
  title        = {Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid beta Protein Fibrillation},
  url          = {http://dx.doi.org/10.1021/cn900027u},
  volume       = {1},
  year         = {2010},
}