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New calculations for internal dosimetry of beta-emitting radiopharmaceuticals

Zankl, M.; Petoussi-Henss, N.; Janzen, T.; Uusijärvi, Helena LU ; Schlattl, H.; Li, W. B.; Giussani, A. and Hoeschen, C. (2010) In Radiation Protection Dosimetry 139(1-3). p.245-249
Abstract
The calculation of absorbed dose from internally incorporated radionuclides is based on the so-called specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRD-type mathematical phantoms. For electrons, the energy released was assumed to be absorbed locally ('ICRP 30 approach'). For this work, photon and electron SAFs were derived with Monte Carlo simulations in the new male voxel-based reference computational phantom adopted by the ICRP and ICRU. The present results show that the assumption of electrons being locally absorbed is not always true at energies above 300-500 keV. For... (More)
The calculation of absorbed dose from internally incorporated radionuclides is based on the so-called specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRD-type mathematical phantoms. For electrons, the energy released was assumed to be absorbed locally ('ICRP 30 approach'). For this work, photon and electron SAFs were derived with Monte Carlo simulations in the new male voxel-based reference computational phantom adopted by the ICRP and ICRU. The present results show that the assumption of electrons being locally absorbed is not always true at energies above 300-500 keV. For source/target organ pairs in close vicinity, high-energy electrons escaping from the source organ may result in cross-fire electron SAFs in the same order of magnitude as those from photons. Examples of organ absorbed doses per unit activity are given for F-18-choline and I-123-iodide. The impact of the new electron SAFs used for absorbed dose calculations compared with the previously used assumptions was found to be small. The organ dose coefficients for the two approaches differ by not more than 6 % for most organs. Only for irradiation of the urinary bladder wall by activity in the contents, the ICRP 30 approach presents an overestimation of approximately 40-50%. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
139
issue
1-3
pages
245 - 249
publisher
Nuclear Technology Publishing
external identifiers
  • wos:000277738200044
  • scopus:77953342655
ISSN
1742-3406
DOI
10.1093/rpd/ncq045
language
English
LU publication?
yes
id
3fc1cc6c-5d73-4586-90e4-c696cf6929ad (old id 1617247)
date added to LUP
2010-06-21 16:32:55
date last changed
2018-05-29 11:55:30
@article{3fc1cc6c-5d73-4586-90e4-c696cf6929ad,
  abstract     = {The calculation of absorbed dose from internally incorporated radionuclides is based on the so-called specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRD-type mathematical phantoms. For electrons, the energy released was assumed to be absorbed locally ('ICRP 30 approach'). For this work, photon and electron SAFs were derived with Monte Carlo simulations in the new male voxel-based reference computational phantom adopted by the ICRP and ICRU. The present results show that the assumption of electrons being locally absorbed is not always true at energies above 300-500 keV. For source/target organ pairs in close vicinity, high-energy electrons escaping from the source organ may result in cross-fire electron SAFs in the same order of magnitude as those from photons. Examples of organ absorbed doses per unit activity are given for F-18-choline and I-123-iodide. The impact of the new electron SAFs used for absorbed dose calculations compared with the previously used assumptions was found to be small. The organ dose coefficients for the two approaches differ by not more than 6 % for most organs. Only for irradiation of the urinary bladder wall by activity in the contents, the ICRP 30 approach presents an overestimation of approximately 40-50%.},
  author       = {Zankl, M. and Petoussi-Henss, N. and Janzen, T. and Uusijärvi, Helena and Schlattl, H. and Li, W. B. and Giussani, A. and Hoeschen, C.},
  issn         = {1742-3406},
  language     = {eng},
  number       = {1-3},
  pages        = {245--249},
  publisher    = {Nuclear Technology Publishing},
  series       = {Radiation Protection Dosimetry},
  title        = {New calculations for internal dosimetry of beta-emitting radiopharmaceuticals},
  url          = {http://dx.doi.org/10.1093/rpd/ncq045},
  volume       = {139},
  year         = {2010},
}