New calculations for internal dosimetry of betaemitting radiopharmaceuticals
(2010) In Radiation Protection Dosimetry 139(13). p.245249 Abstract
 The calculation of absorbed dose from internally incorporated radionuclides is based on the socalled specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRDtype mathematical phantoms. For electrons, the energy released was assumed to be absorbed locally ('ICRP 30 approach'). For this work, photon and electron SAFs were derived with Monte Carlo simulations in the new male voxelbased reference computational phantom adopted by the ICRP and ICRU. The present results show that the assumption of electrons being locally absorbed is not always true at energies above 300500 keV. For... (More)
 The calculation of absorbed dose from internally incorporated radionuclides is based on the socalled specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRDtype mathematical phantoms. For electrons, the energy released was assumed to be absorbed locally ('ICRP 30 approach'). For this work, photon and electron SAFs were derived with Monte Carlo simulations in the new male voxelbased reference computational phantom adopted by the ICRP and ICRU. The present results show that the assumption of electrons being locally absorbed is not always true at energies above 300500 keV. For source/target organ pairs in close vicinity, highenergy electrons escaping from the source organ may result in crossfire electron SAFs in the same order of magnitude as those from photons. Examples of organ absorbed doses per unit activity are given for F18choline and I123iodide. The impact of the new electron SAFs used for absorbed dose calculations compared with the previously used assumptions was found to be small. The organ dose coefficients for the two approaches differ by not more than 6 % for most organs. Only for irradiation of the urinary bladder wall by activity in the contents, the ICRP 30 approach presents an overestimation of approximately 4050%. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/1617247
 author
 Zankl, M.; PetoussiHenss, N.; Janzen, T.; Uusijärvi, Helena ^{LU} ; Schlattl, H.; Li, W. B.; Giussani, A. and Hoeschen, C.
 organization
 publishing date
 2010
 type
 Contribution to journal
 publication status
 published
 subject
 in
 Radiation Protection Dosimetry
 volume
 139
 issue
 13
 pages
 245  249
 publisher
 Nuclear Technology Publishing
 external identifiers

 wos:000277738200044
 scopus:77953342655
 ISSN
 17423406
 DOI
 10.1093/rpd/ncq045
 language
 English
 LU publication?
 yes
 id
 3fc1cc6c5d73458690e4c696cf6929ad (old id 1617247)
 date added to LUP
 20100621 16:32:55
 date last changed
 20180529 11:55:30
@article{3fc1cc6c5d73458690e4c696cf6929ad, abstract = {The calculation of absorbed dose from internally incorporated radionuclides is based on the socalled specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRDtype mathematical phantoms. For electrons, the energy released was assumed to be absorbed locally ('ICRP 30 approach'). For this work, photon and electron SAFs were derived with Monte Carlo simulations in the new male voxelbased reference computational phantom adopted by the ICRP and ICRU. The present results show that the assumption of electrons being locally absorbed is not always true at energies above 300500 keV. For source/target organ pairs in close vicinity, highenergy electrons escaping from the source organ may result in crossfire electron SAFs in the same order of magnitude as those from photons. Examples of organ absorbed doses per unit activity are given for F18choline and I123iodide. The impact of the new electron SAFs used for absorbed dose calculations compared with the previously used assumptions was found to be small. The organ dose coefficients for the two approaches differ by not more than 6 % for most organs. Only for irradiation of the urinary bladder wall by activity in the contents, the ICRP 30 approach presents an overestimation of approximately 4050%.}, author = {Zankl, M. and PetoussiHenss, N. and Janzen, T. and Uusijärvi, Helena and Schlattl, H. and Li, W. B. and Giussani, A. and Hoeschen, C.}, issn = {17423406}, language = {eng}, number = {13}, pages = {245249}, publisher = {Nuclear Technology Publishing}, series = {Radiation Protection Dosimetry}, title = {New calculations for internal dosimetry of betaemitting radiopharmaceuticals}, url = {http://dx.doi.org/10.1093/rpd/ncq045}, volume = {139}, year = {2010}, }