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Total adiponectin does not predict cardiovascular events in middle-aged men in a prospective, long-term follow-up study

Khalili, P.; Flyvbjerg, A.; Frystyk, J.; Lundin, F.; Jendle, J.; Engström, Gunnar LU and Nilsson, Peter LU (2010) In Diabetes & Metabolism1996-01-01+01:00 36(2). p.137-143
Abstract
Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total... (More)
Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total adiponectin and the first incidence of fatal or non-fatal cardiovascular disease (CVD) was analyzed, using Cox's proportional-hazards regression model. Results. In a separate multiple-regression analysis and after adjusting for possible confounders, the relationship between adiponectin levels and markers of glucose metabolism were found to be significant (P<0.05). However, adiponectin did not independently predict the risk of stroke, coronary events, or a combination of these two outcomes. Conclusion. Levels of total plasma adiponectin are not useful for predicting long-term cardiovascular events in middle-aged men, but are strongly associated with glucose metabolism and markers of insulin resistance. (c) 2010 Elsevier Masson SAS. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
metabolism, Glucose, Coronary events, Adiponectin, Cardiovascular events, Stroke, Prospective study, Long-term
in
Diabetes & Metabolism1996-01-01+01:00
volume
36
issue
2
pages
137 - 143
publisher
Masson Editeur
external identifiers
  • wos:000277835800007
  • scopus:77953286453
ISSN
1878-1780
DOI
10.1016/j.diabet.2009.10.004
language
English
LU publication?
yes
id
b0515351-34d2-46f2-9c61-be0cd4f74a1c (old id 1617576)
date added to LUP
2010-06-21 13:45:05
date last changed
2018-05-29 11:30:28
@article{b0515351-34d2-46f2-9c61-be0cd4f74a1c,
  abstract     = {Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adiponectin was analyzed. All individuals had undergone an oral glucose tolerance test (OGTTs), and the mean follow-up duration was 27 years. Regression analyses were carried out for indices of glucose metabolism in relation to quintiles (Q1-Q5) of total aliponectin levels. After stratification for smoking or not, the association between total adiponectin and the first incidence of fatal or non-fatal cardiovascular disease (CVD) was analyzed, using Cox's proportional-hazards regression model. Results. In a separate multiple-regression analysis and after adjusting for possible confounders, the relationship between adiponectin levels and markers of glucose metabolism were found to be significant (P&lt;0.05). However, adiponectin did not independently predict the risk of stroke, coronary events, or a combination of these two outcomes. Conclusion. Levels of total plasma adiponectin are not useful for predicting long-term cardiovascular events in middle-aged men, but are strongly associated with glucose metabolism and markers of insulin resistance. (c) 2010 Elsevier Masson SAS. All rights reserved.},
  author       = {Khalili, P. and Flyvbjerg, A. and Frystyk, J. and Lundin, F. and Jendle, J. and Engström, Gunnar and Nilsson, Peter},
  issn         = {1878-1780},
  keyword      = {metabolism,Glucose,Coronary events,Adiponectin,Cardiovascular events,Stroke,Prospective study,Long-term},
  language     = {eng},
  number       = {2},
  pages        = {137--143},
  publisher    = {Masson Editeur},
  series       = {Diabetes & Metabolism1996-01-01+01:00},
  title        = {Total adiponectin does not predict cardiovascular events in middle-aged men in a prospective, long-term follow-up study},
  url          = {http://dx.doi.org/10.1016/j.diabet.2009.10.004},
  volume       = {36},
  year         = {2010},
}