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Identification of Novel Spinal Cholinergic Genetic Subtypes Disclose Chodl and Pitx2 as Markers for Fast Motor Neurons and Partition Cells

Enjin, Anders; Rabe, Nadine; Nakanishi, Stan T.; Vallstedt, Anna; Gezelius, Henrik; Memic, Fatima; Lind, Magnus; Hjalt, Tord LU ; Tourtellotte, Warren G. and Bruder, Carl, et al. (2010) In Journal of Comparative Neurology 518(12). p.2284-2304
Abstract
Spinal cholinergic neurons are critical for motor function in both the autonomic and somatic nervous systems and are affected in spinal cord injury and in diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. Using two screening approaches and in situ hybridization, we identified 159 genes expressed in typical cholinergic patterns in the spinal cord. These include two general cholinergic neuron markers, one gene exclusively expressed in motor neurons, and nine genes expressed in unknown sub-types of somatic motor neurons. Further, we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERR beta) is a candidate marker for slow motor neurons. In... (More)
Spinal cholinergic neurons are critical for motor function in both the autonomic and somatic nervous systems and are affected in spinal cord injury and in diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. Using two screening approaches and in situ hybridization, we identified 159 genes expressed in typical cholinergic patterns in the spinal cord. These include two general cholinergic neuron markers, one gene exclusively expressed in motor neurons, and nine genes expressed in unknown sub-types of somatic motor neurons. Further, we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERR beta) is a candidate marker for slow motor neurons. In addition, we suggest paired-like homeodomain transcription factor 2 (Pitx2) as a marker for cholinergic partition cells. J. Comp. Neurol. 518:2284-2304, 2010. (C) 2010 Wiley-Liss, Inc. (Less)
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publication status
published
subject
keywords
cord, spinal, motor neuron, interneuron, mouse genetics, neuronal network, genetic screen
in
Journal of Comparative Neurology
volume
518
issue
12
pages
2284 - 2304
publisher
John Wiley & Sons
external identifiers
  • wos:000277580600007
  • scopus:77952150453
ISSN
1096-9861
DOI
10.1002/cne.22332
language
English
LU publication?
yes
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3992a1e4-fd74-4aee-9b7c-591af9b9767e (old id 1617791)
date added to LUP
2010-06-21 10:50:15
date last changed
2018-05-29 12:24:58
@article{3992a1e4-fd74-4aee-9b7c-591af9b9767e,
  abstract     = {Spinal cholinergic neurons are critical for motor function in both the autonomic and somatic nervous systems and are affected in spinal cord injury and in diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. Using two screening approaches and in situ hybridization, we identified 159 genes expressed in typical cholinergic patterns in the spinal cord. These include two general cholinergic neuron markers, one gene exclusively expressed in motor neurons, and nine genes expressed in unknown sub-types of somatic motor neurons. Further, we present evidence that chondrolectin (Chodl) is expressed by fast motor neurons and that estrogen-related receptor beta (ERR beta) is a candidate marker for slow motor neurons. In addition, we suggest paired-like homeodomain transcription factor 2 (Pitx2) as a marker for cholinergic partition cells. J. Comp. Neurol. 518:2284-2304, 2010. (C) 2010 Wiley-Liss, Inc.},
  author       = {Enjin, Anders and Rabe, Nadine and Nakanishi, Stan T. and Vallstedt, Anna and Gezelius, Henrik and Memic, Fatima and Lind, Magnus and Hjalt, Tord and Tourtellotte, Warren G. and Bruder, Carl and Eichele, Gregor and Whelan, Patrick J. and Kullander, Klas},
  issn         = {1096-9861},
  keyword      = {cord,spinal,motor neuron,interneuron,mouse genetics,neuronal network,genetic screen},
  language     = {eng},
  number       = {12},
  pages        = {2284--2304},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Comparative Neurology},
  title        = {Identification of Novel Spinal Cholinergic Genetic Subtypes Disclose Chodl and Pitx2 as Markers for Fast Motor Neurons and Partition Cells},
  url          = {http://dx.doi.org/10.1002/cne.22332},
  volume       = {518},
  year         = {2010},
}