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Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study

Poynter, Jenny N.; Langholz, Bryan; Largent, Joan; Mellemkjaer, Lene; Bernstein, Leslie; Malone, Kathleen E.; Lynch, Charles F.; Borg, Åke LU ; Concannon, Patrick and Teraoka, Sharon N., et al. (2010) In Cancer Causes and Control 21(6). p.839-846
Abstract
Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of developing contralateral breast cancer (CBC). In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers. The WECARE Study is a population-based multi-center case-control study of 705 women with CBC (cases) and 1,397 women with unilateral breast cancer (controls). All participants were screened for BRCA1/2 mutations and 181 carriers were identified. Conditional logistic regression models were used to evaluate associations between reproductive factors and... (More)
Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of developing contralateral breast cancer (CBC). In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers. The WECARE Study is a population-based multi-center case-control study of 705 women with CBC (cases) and 1,397 women with unilateral breast cancer (controls). All participants were screened for BRCA1/2 mutations and 181 carriers were identified. Conditional logistic regression models were used to evaluate associations between reproductive factors and CBC for mutation carriers and non-carriers. None of the associations between reproductive factors and CBC risk differed between mutation carriers and non-carriers. The increase in risk with younger age at menarche and decrease in risk in women with more than two full-term pregnancies seen in non-carriers were not significantly different in carriers (adjusted RRs = 1.31, 95% CI 0.65-2.65 and 0.53, 95% CI 0.19-1.51, respectively). No significant associations between the other reproductive factors and CBC risk were observed in mutation carriers or non-carriers. For two reproductive factors previously shown to be associated with CBC risk, we observed similar associations for BRCA1/2 carriers. This suggests that reproductive variables that affect CBC risk may have similar effects in mutation carriers and non-carriers. (Less)
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published
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keywords
Reproductive factors, Contralateral breast cancer, BRCA1, BRCA2
in
Cancer Causes and Control
volume
21
issue
6
pages
839 - 846
publisher
Springer
external identifiers
  • wos:000277709800005
  • scopus:77955663595
ISSN
1573-7225
DOI
10.1007/s10552-010-9510-0
language
English
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yes
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55676fdc-f539-432a-974c-fe40fef097d0 (old id 1618034)
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http://www.ncbi.nlm.nih.gov/sites/pubmed
date added to LUP
2010-06-21 09:10:24
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2018-05-29 10:33:16
@article{55676fdc-f539-432a-974c-fe40fef097d0,
  abstract     = {Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of developing contralateral breast cancer (CBC). In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers. The WECARE Study is a population-based multi-center case-control study of 705 women with CBC (cases) and 1,397 women with unilateral breast cancer (controls). All participants were screened for BRCA1/2 mutations and 181 carriers were identified. Conditional logistic regression models were used to evaluate associations between reproductive factors and CBC for mutation carriers and non-carriers. None of the associations between reproductive factors and CBC risk differed between mutation carriers and non-carriers. The increase in risk with younger age at menarche and decrease in risk in women with more than two full-term pregnancies seen in non-carriers were not significantly different in carriers (adjusted RRs = 1.31, 95% CI 0.65-2.65 and 0.53, 95% CI 0.19-1.51, respectively). No significant associations between the other reproductive factors and CBC risk were observed in mutation carriers or non-carriers. For two reproductive factors previously shown to be associated with CBC risk, we observed similar associations for BRCA1/2 carriers. This suggests that reproductive variables that affect CBC risk may have similar effects in mutation carriers and non-carriers.},
  author       = {Poynter, Jenny N. and Langholz, Bryan and Largent, Joan and Mellemkjaer, Lene and Bernstein, Leslie and Malone, Kathleen E. and Lynch, Charles F. and Borg, Åke and Concannon, Patrick and Teraoka, Sharon N. and Xue, Shanyan and Diep, Anh T. and Törngren, Therese and Begg, Colin B. and Capanu, Marinela and Haile, Robert W. and Bernstein, Jonine L.},
  issn         = {1573-7225},
  keyword      = {Reproductive factors,Contralateral breast cancer,BRCA1,BRCA2},
  language     = {eng},
  number       = {6},
  pages        = {839--846},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study},
  url          = {http://dx.doi.org/10.1007/s10552-010-9510-0},
  volume       = {21},
  year         = {2010},
}