Advanced

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Lindgren, Cecilia M.; Heid, Iris M.; Randall, Joshua C.; Lamina, Claudia; Steinthorsdottir, Valgerdur; Qi, Lu; Speliotes, Elizabeth K.; Thorleifsson, Gudmar; Willer, Cristen J. and Herrera, Blanca M., et al. (2010) In PLoS Genetics 5(6).
Abstract
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P=8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.66x10(-8)). The variants near TFAP2B... (More)
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P=8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.66x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS Genetics
volume
5
issue
6
publisher
Public Library of Science
external identifiers
  • wos:000277354200004
  • scopus:67651236725
ISSN
1553-7404
DOI
10.1371/journal.pgen.1000508
language
English
LU publication?
yes
id
e86542bb-e6d1-4077-9b7f-fa0cfe38951a (old id 1618149)
date added to LUP
2010-06-21 10:39:01
date last changed
2018-07-08 03:04:09
@article{e86542bb-e6d1-4077-9b7f-fa0cfe38951a,
  abstract     = {To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P=8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.66x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.},
  author       = {Lindgren, Cecilia M. and Heid, Iris M. and Randall, Joshua C. and Lamina, Claudia and Steinthorsdottir, Valgerdur and Qi, Lu and Speliotes, Elizabeth K. and Thorleifsson, Gudmar and Willer, Cristen J. and Herrera, Blanca M. and Jackson, Anne U. and Lim, Noha and Scheet, Paul and Soranzo, Nicole and Amin, Najaf and Aulchenko, Yurii S. and Chambers, John C. and Drong, Alexander and Luan, Jian'an and Lyon, Helen N. and Rivadeneira, Fernando and Sanna, Serena and Timpson, Nicholas J. and Zillikens, M. Carola and Zhao, Jing Hua and Almgren, Peter and Bandinelli, Stefania and Bennett, Amanda J. and Bergman, Richard N. and Bonnycastle, Lori L. and Bumpstead, Suzannah J. and Chanock, Stephen J. and Cherkas, Lynn and Chines, Peter and Coin, Lachlan and Cooper, Cyrus and Crawford, Gabriel and Doering, Angela and Dominiczak, Anna and Doney, Alex S. F. and Ebrahim, Shah and Elliott, Paul and Erdos, Michael R. and Estrada, Karol and Ferrucci, Luigi and Fischer, Guido and Forouhi, Nita G. and Gieger, Christian and Grallert, Harald and Groves, Christopher J. and Grundy, Scott and Guiducci, Candace and Hadley, David and Hamsten, Anders and Havulinna, Aki S. and Hofman, Albert and Holle, Rolf and Holloway, John W. and Illig, Thomas and Isomaa, Bo and Jacobs, Leonie C. and Jameson, Karen and Jousilahti, Pekka and Karpe, Fredrik and Kuusisto, Johanna and Laitinen, Jaana and Lathrop, G. Mark and Lawlor, Debbie A. and Mangino, Massimo and McArdle, Wendy L. and Meitinger, Thomas and Morken, Mario A. and Morris, Andrew P. and Munroe, Patricia and Narisu, Narisu and Nordstrom, Anna and Nordstrom, Peter and Oostra, Ben A. and Palmer, Colin N. A. and Payne, Felicity and Peden, John F. and Prokopenko, Inga and Renstrom, Frida and Ruokonen, Aimo and Salomaa, Veikko and Sandhu, Manjinder S. and Scott, Laura J. and Scuteri, Angelo and Silander, Kaisa and Song, Kijoung and Yuan, Xin and Stringham, Heather M. and Swift, Amy J. and Tuomi, Tiinamaija and Uda, Manuela and Vollenweider, Peter and Waeber, Gerard and Wallace, Chris and Walters, G. Bragi and Weedon, Michael N. and Witteman, Jacqueline C. M. and Zhang, Cuilin and Zhang, Weihua and Caulfield, Mark J. and Collins, Francis S. and Smith, George Davey and Day, Ian N. M. and Franks, Paul and Hattersley, Andrew T. and Hu, Frank B. and Jarvelin, Marjo-Riitta and Kong, Augustine and Kooner, Jaspal S. and Laakso, Markku and Lakatta, Edward and Mooser, Vincent and Morris, Andrew D. and Peltonen, Leena and Samani, Nilesh J. and Spector, Timothy D. and Strachan, David P. and Tanaka, Toshiko and Tuomilehto, Jaakko and Uitterlinden, Andre G. and van Duijn, Cornelia M. and Wareham, Nicholas J. and Waterworth, Dawn M. and Boehnke, Michael and Deloukas, Panos and Groop, Leif and Hunter, David J. and Thorsteinsdottir, Unnur and Schlessinger, David and Wichmann, H. -Erich and Frayling, Timothy M. and Abecasis, Goncalo R. and Hirschhorn, Joel N. and Loos, Ruth J. F. and Stefansson, Kari and Mohlke, Karen L. and Barroso, Ines and McCarthy, Mark I.},
  issn         = {1553-7404},
  language     = {eng},
  number       = {6},
  publisher    = {Public Library of Science},
  series       = {PLoS Genetics},
  title        = {Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution},
  url          = {http://dx.doi.org/10.1371/journal.pgen.1000508},
  volume       = {5},
  year         = {2010},
}