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C-14 sample preparation for AMS microdosing studies at Lund University using online combustion and septa-sealed vials

Sydoff, Marie LU and Stenström, Kristina LU (2010) 11th International Conference on Accelerator Mass Spectrometry In Nuclear Instruments & Methods In Physics Research Section B-Beam Interactions With Materials And Atoms 268(7-8). p.924-926
Abstract
The Department of Physics at Lund University is participating in a European Union project called EUMAPP (European Union Microdose AMS Partnership Programme), in which sample preparation and accelerator mass spectrometry (AMS) measurements of biological samples from microdosing studies have been made. This paper describes a simplified method of converting biological samples to solid graphite for C-14 analysis with AMS. The method is based on online combustion of the samples, and reduction of CO2 in septa-sealed vials. The septa-sealed vials and disposable materials are used to eliminate sample cross-contamination. Measurements of ANU and Ox I standards show deviations of 2% and 3%, respectively, relative to reference values. This level of... (More)
The Department of Physics at Lund University is participating in a European Union project called EUMAPP (European Union Microdose AMS Partnership Programme), in which sample preparation and accelerator mass spectrometry (AMS) measurements of biological samples from microdosing studies have been made. This paper describes a simplified method of converting biological samples to solid graphite for C-14 analysis with AMS. The method is based on online combustion of the samples, and reduction of CO2 in septa-sealed vials. The septa-sealed vials and disposable materials are used to eliminate sample cross-contamination. Measurements of ANU and Ox I standards show deviations of 2% and 3%, respectively, relative to reference values. This level of accuracy is sufficient for biological samples from microdosing studies. Since the method has very few handling steps from sample to graphite, the risk of failure during the sample preparation process is minimized, making the method easy to use in routine preparation of samples. (C) 2009 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Online combustion, Septa-sealed vials, Sample preparation, Graphitization, Microdosing, AMS, C-14
in
Nuclear Instruments & Methods In Physics Research Section B-Beam Interactions With Materials And Atoms
volume
268
issue
7-8
pages
924 - 926
publisher
Elsevier
conference name
11th International Conference on Accelerator Mass Spectrometry
external identifiers
  • wos:000277462300061
  • scopus:77949891861
ISSN
0168-583X
DOI
10.1016/j.nimb.2009.10.065
language
English
LU publication?
yes
id
cb273d96-fcd9-43cf-a1ee-dfc934a1811e (old id 1618305)
date added to LUP
2010-06-22 10:29:40
date last changed
2018-06-17 04:39:35
@inproceedings{cb273d96-fcd9-43cf-a1ee-dfc934a1811e,
  abstract     = {The Department of Physics at Lund University is participating in a European Union project called EUMAPP (European Union Microdose AMS Partnership Programme), in which sample preparation and accelerator mass spectrometry (AMS) measurements of biological samples from microdosing studies have been made. This paper describes a simplified method of converting biological samples to solid graphite for C-14 analysis with AMS. The method is based on online combustion of the samples, and reduction of CO2 in septa-sealed vials. The septa-sealed vials and disposable materials are used to eliminate sample cross-contamination. Measurements of ANU and Ox I standards show deviations of 2% and 3%, respectively, relative to reference values. This level of accuracy is sufficient for biological samples from microdosing studies. Since the method has very few handling steps from sample to graphite, the risk of failure during the sample preparation process is minimized, making the method easy to use in routine preparation of samples. (C) 2009 Elsevier B.V. All rights reserved.},
  author       = {Sydoff, Marie and Stenström, Kristina},
  booktitle    = {Nuclear Instruments & Methods In Physics Research Section B-Beam Interactions With Materials And Atoms},
  issn         = {0168-583X},
  keyword      = {Online combustion,Septa-sealed vials,Sample preparation,Graphitization,Microdosing,AMS,C-14},
  language     = {eng},
  number       = {7-8},
  pages        = {924--926},
  publisher    = {Elsevier},
  title        = {C-14 sample preparation for AMS microdosing studies at Lund University using online combustion and septa-sealed vials},
  url          = {http://dx.doi.org/10.1016/j.nimb.2009.10.065},
  volume       = {268},
  year         = {2010},
}