Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors
(2020) In Biophysical Journal 119(7). p.1275-1280- Abstract
Carbonic anhydrase (CA) is a thoroughly studied enzyme. Its primary role is the rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produced, and in the lungs, where it is released from the blood. At the same time, it regulates pH homeostasis. The inhibitory function of sulfonamides on CA was discovered some 80 years ago. There are numerous physiological-therapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glaucoma, or act as diuretics. With the realization that several isoenzymes of carbonic anhydrase are associated with the development of several types of cancer, such as brain and breast cancer, the development of inhibitor drugs specific to those... (More)
Carbonic anhydrase (CA) is a thoroughly studied enzyme. Its primary role is the rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produced, and in the lungs, where it is released from the blood. At the same time, it regulates pH homeostasis. The inhibitory function of sulfonamides on CA was discovered some 80 years ago. There are numerous physiological-therapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glaucoma, or act as diuretics. With the realization that several isoenzymes of carbonic anhydrase are associated with the development of several types of cancer, such as brain and breast cancer, the development of inhibitor drugs specific to those enzyme forms has exploded. We would like to highlight the breadth of research on the enzyme as well as draw the attention to some problems in recent published work on inhibitor discovery.
(Less)
- author
- Jonsson, Bengt Harald and Liljas, Anders LU
- organization
- publishing date
- 2020-10-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biophysical Journal
- volume
- 119
- issue
- 7
- pages
- 6 pages
- publisher
- Cell Press
- external identifiers
-
- pmid:32910900
- scopus:85090482889
- ISSN
- 0006-3495
- DOI
- 10.1016/j.bpj.2020.08.020
- language
- English
- LU publication?
- yes
- id
- 1618516d-1786-40c4-8b8a-11c0a4c23f3f
- date added to LUP
- 2020-10-02 15:03:03
- date last changed
- 2024-04-03 14:06:36
@article{1618516d-1786-40c4-8b8a-11c0a4c23f3f,
abstract = {{<p>Carbonic anhydrase (CA) is a thoroughly studied enzyme. Its primary role is the rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produced, and in the lungs, where it is released from the blood. At the same time, it regulates pH homeostasis. The inhibitory function of sulfonamides on CA was discovered some 80 years ago. There are numerous physiological-therapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glaucoma, or act as diuretics. With the realization that several isoenzymes of carbonic anhydrase are associated with the development of several types of cancer, such as brain and breast cancer, the development of inhibitor drugs specific to those enzyme forms has exploded. We would like to highlight the breadth of research on the enzyme as well as draw the attention to some problems in recent published work on inhibitor discovery.</p>}},
author = {{Jonsson, Bengt Harald and Liljas, Anders}},
issn = {{0006-3495}},
language = {{eng}},
month = {{10}},
number = {{7}},
pages = {{1275--1280}},
publisher = {{Cell Press}},
series = {{Biophysical Journal}},
title = {{Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors}},
url = {{http://dx.doi.org/10.1016/j.bpj.2020.08.020}},
doi = {{10.1016/j.bpj.2020.08.020}},
volume = {{119}},
year = {{2020}},
}