Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)
(2010) In Archives of Internal Medicine 170(9). p.791-802- Abstract
- Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight,... (More)
- Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, >= 35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58; P-trend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69; P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70; P-trend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women. Arch Intern Med. 2010;170(9):791 -802 (Less)
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- Archives of Internal Medicine
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- 170
- issue
- 9
- pages
- 791 - 802
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- American Medical Association
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- scopus:77952177097
- ISSN
- 0003-9926
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- English
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@article{7423072f-debc-44a5-94c9-075b74888d57,
abstract = {{Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, >= 35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58; P-trend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69; P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70; P-trend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women. Arch Intern Med. 2010;170(9):791 -802}},
author = {{Arslan, Alan A. and Helzlsouer, Kathy J. and Kooperberg, Charles and Shu, Xiao-Ou and Steplowski, Emily and Bueno-de-Mesquita, H. Bas and Fuchs, Charles S. and Gross, Myron D. and Jacobs, Eric J. and LaCroix, Andrea Z. and Petersen, Gloria M. and Stolzenberg-Solomon, Rachael Z. and Zheng, Wei and Albanes, Demetrius and Amundadottir, Laufey and Bamlet, William R. and Barricarte, Aurelio and Bingham, Sheila A. and Boeing, Heiner and Boutron-Ruault, Marie-Christine and Buring, Julie E. and Chanock, Stephen J. and Clipp, Sandra and Gaziano, J. Michael and Giovannucci, Edward L. and Hankinson, Susan E. and Hartge, Patricia and Hoover, Robert N. and Hunter, David J. and Hutchinson, Amy and Jacobs, Kevin B. and Kraft, Peter and Lynch, Shannon M. and Manjer, Jonas and Manson, JoAnn E. and McTiernan, Anne and McWilliams, Robert R. and Mendelsohn, Julie B. and Michaud, Dominique S. and Palli, Domenico and Rohan, Thomas E. and Slimani, Nadia and Thomas, Gilles and Tjonneland, Anne and Tobias, Geoffrey S. and Trichopoulos, Ditnitrios and Virtamo, Jarmo and Wolpin, Brian M. and Yu, Kai and Zeleniuch-Jacquotte, Anne and Patel, Alpa V.}},
issn = {{0003-9926}},
language = {{eng}},
number = {{9}},
pages = {{791--802}},
publisher = {{American Medical Association}},
series = {{Archives of Internal Medicine}},
title = {{Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)}},
url = {{http://archinte.ama-assn.org/cgi/content/short/170/9/791}},
volume = {{170}},
year = {{2010}},
}