Advanced

Genetic loci influencing kidney function and chronic kidney disease

Chambers, John C.; Zhang, Weihua; Lord, Graham M.; van der Harst, Pim; Lawlor, Debbie A.; Sehmi, Joban S.; Gale, Daniel P.; Wass, Mark N.; Ahmadi, Kourosh R. and Bakker, Stephan J. L., et al. (2010) In Nature Genetics 42(5). p.373-375
Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
42
issue
5
pages
373 - 375
publisher
Nature Publishing Group
external identifiers
  • wos:000277179500005
  • scopus:77951768942
ISSN
1546-1718
DOI
10.1038/ng.566
language
English
LU publication?
yes
id
19f98906-09b8-4ccd-8d8f-b7f361c16278 (old id 1619028)
date added to LUP
2010-06-18 14:29:06
date last changed
2018-05-29 12:20:13
@article{19f98906-09b8-4ccd-8d8f-b7f361c16278,
  abstract     = {Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.},
  author       = {Chambers, John C. and Zhang, Weihua and Lord, Graham M. and van der Harst, Pim and Lawlor, Debbie A. and Sehmi, Joban S. and Gale, Daniel P. and Wass, Mark N. and Ahmadi, Kourosh R. and Bakker, Stephan J. L. and Beckmann, Jacqui and Bilo, Henk J. G. and Bochud, Murielle and Brown, Morris J. and Caulfield, Mark J. and Connell, John M. C. and Cook, H. Terence and Cotlarciuc, Ioana and Smith, George Davey and de Silva, Ranil and Deng, Guohong and Devuyst, Olivier and Dikkeschei, Lambert D. and Dimkovic, Nada and Dockrell, Mark and Dominiczak, Anna and Ebrahim, Shah and Eggermann, Thomas and Farrall, Martin and Ferrucci, Luigi and Floege, Jurgen and Forouhi, Nita G. and Gansevoort, Ron T. and Han, Xijin and Hedblad, Bo and van der Heide, Jaap J. Homan and Hepkema, Bouke G. and Hernandez-Fuentes, Maria and Hypponen, Elina and Johnson, Toby and de Jong, Paul E. and Kleefstra, Nanne and Lagou, Vasiliki and Lapsley, Marta and Li, Yun and Loos, Ruth J. F. and Luan, Jian'an and Luttropp, Karin and Marechal, Celine and Melander, Olle and Munroe, Patricia B. and Nordfors, Louise and Parsa, Afshin and Peltonen, Leena and Penninx, Brenda W. and Perucha, Esperanza and Pouta, Anneli and Prokopenko, Inga and Roderick, Paul J. and Ruokonen, Aimo and Samani, Nilesh J. and Sanna, Serena and Schalling, Martin and Schlessinger, David and Schlieper, Georg and Seelen, Marc A. J. and Shuldiner, Alan R. and Sjögren, Marketa and Smit, Johannes H. and Snieder, Harold and Soranzo, Nicole and Spector, Timothy D. and Stenvinkel, Peter and Sternberg, Michael J. E. and Swaminathan, Ramasamyiyer and Tanaka, Toshiko and Ubink-Veltmaat, Lielith J. and Uda, Manuela and Vollenweider, Peter and Wallace, Chris and Waterworth, Dawn and Zerres, Klaus and Waeber, Gerard and Wareham, Nicholas J. and Maxwell, Patrick H. and McCarthy, Mark I. and Jarvelin, Marjo-Riitta and Mooser, Vincent and Abecasis, Goncalo R. and Lightstone, Liz and Scott, James and Navis, Gerjan and Elliott, Paul and Kooner, Jaspal S.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {5},
  pages        = {373--375},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Genetic loci influencing kidney function and chronic kidney disease},
  url          = {http://dx.doi.org/10.1038/ng.566},
  volume       = {42},
  year         = {2010},
}