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Ventilation-Perfusion SPECT with Tc-99m-DTPA Versus Technegas: A Head-to-Head Study in Obstructive and Nonobstructive Disease

Jögi, Jonas LU ; Jonson, Björn LU ; Ekberg, Marie LU and Bajc, Marika LU (2010) In Journal of Nuclear Medicine 51(5). p.735-741
Abstract
Lung scintigraphy is primarily used to diagnose pulmonary embolism. Ventilation imaging is often performed using Tc-99m-DTPA or Technegas, an ultrafine dispersion of Tc-99m-labeled carbon. Despite the common use of these radioaerosols, they have not been compared in an intraindividual study, and not with ventilation-perfusion (V/P) SPECT. The aim of the present head-to-head study was to systematically investigate differences in ventilation studies performed with Tc-99m-diethylenetriaminepentaacetate (DTPA) and Technegas. Methods: Sixty-three patients, 28 without and 35 with obstructive lung disease, were examined with V/P SPECT using both Tc-99m-DTPA and Technegas. V/P SPECT images were randomized and assessed independently by 2 masked... (More)
Lung scintigraphy is primarily used to diagnose pulmonary embolism. Ventilation imaging is often performed using Tc-99m-DTPA or Technegas, an ultrafine dispersion of Tc-99m-labeled carbon. Despite the common use of these radioaerosols, they have not been compared in an intraindividual study, and not with ventilation-perfusion (V/P) SPECT. The aim of the present head-to-head study was to systematically investigate differences in ventilation studies performed with Tc-99m-diethylenetriaminepentaacetate (DTPA) and Technegas. Methods: Sixty-three patients, 28 without and 35 with obstructive lung disease, were examined with V/P SPECT using both Tc-99m-DTPA and Technegas. V/P SPECT images were randomized and assessed independently by 2 masked physicians according to a predefined scoring system. A paired comparison was performed using the Wilcoxon signed-rank test. Results: In both obstructive and nonobstructive disease, the overall unevenness of radiotracer deposition and the degree of central deposition were more pronounced in Tc-99m-DTPA than Technegas studies. Because of better peripheral penetration, the extent of reverse mismatch was less when Technegas was used. Additionally, in obstructive disease, the degree of focal deposition in distal airways was more pronounced with Tc-99m-DTPA. Mismatched perfusion defects were more frequently found with Technegas in obstructive disease. Conclusion: This intraindividual comparative study shows that Technegas is the preferred radioaerosol, particularly in obstructive disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
COPD, computed tomography (V/P SPECT), pulmonary embolism, ventilation-perfusion single-photon emission, Tc-99m-DTPA, Technegas
in
Journal of Nuclear Medicine
volume
51
issue
5
pages
735 - 741
publisher
Society of Nuclear Medicine
external identifiers
  • wos:000277239000015
  • pmid:20395338
  • scopus:77952296618
ISSN
0161-5505
DOI
10.2967/jnumed.109.073957
language
English
LU publication?
yes
id
f2dc6116-e4a4-4a06-bc7d-f09cd98244bf (old id 1619384)
alternative location
http://www.ncbi.nlm.nih.gov/sites/pubmed
date added to LUP
2010-06-22 09:33:49
date last changed
2018-06-24 03:10:09
@article{f2dc6116-e4a4-4a06-bc7d-f09cd98244bf,
  abstract     = {Lung scintigraphy is primarily used to diagnose pulmonary embolism. Ventilation imaging is often performed using Tc-99m-DTPA or Technegas, an ultrafine dispersion of Tc-99m-labeled carbon. Despite the common use of these radioaerosols, they have not been compared in an intraindividual study, and not with ventilation-perfusion (V/P) SPECT. The aim of the present head-to-head study was to systematically investigate differences in ventilation studies performed with Tc-99m-diethylenetriaminepentaacetate (DTPA) and Technegas. Methods: Sixty-three patients, 28 without and 35 with obstructive lung disease, were examined with V/P SPECT using both Tc-99m-DTPA and Technegas. V/P SPECT images were randomized and assessed independently by 2 masked physicians according to a predefined scoring system. A paired comparison was performed using the Wilcoxon signed-rank test. Results: In both obstructive and nonobstructive disease, the overall unevenness of radiotracer deposition and the degree of central deposition were more pronounced in Tc-99m-DTPA than Technegas studies. Because of better peripheral penetration, the extent of reverse mismatch was less when Technegas was used. Additionally, in obstructive disease, the degree of focal deposition in distal airways was more pronounced with Tc-99m-DTPA. Mismatched perfusion defects were more frequently found with Technegas in obstructive disease. Conclusion: This intraindividual comparative study shows that Technegas is the preferred radioaerosol, particularly in obstructive disease.},
  author       = {Jögi, Jonas and Jonson, Björn and Ekberg, Marie and Bajc, Marika},
  issn         = {0161-5505},
  keyword      = {COPD,computed tomography (V/P SPECT),pulmonary embolism,ventilation-perfusion single-photon emission,Tc-99m-DTPA,Technegas},
  language     = {eng},
  number       = {5},
  pages        = {735--741},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {Ventilation-Perfusion SPECT with Tc-99m-DTPA Versus Technegas: A Head-to-Head Study in Obstructive and Nonobstructive Disease},
  url          = {http://dx.doi.org/10.2967/jnumed.109.073957},
  volume       = {51},
  year         = {2010},
}