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Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men

Ooi, Esther M. M.; Watts, Gerald F.; Chan, Dick C.; Nielsen, Lars B.; Plomgaard, Peter; Dahlbäck, Björn LU and Barrett, P. Hugh R. (2010) In Atherosclerosis 210(1). p.326-330
Abstract
Objective: The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men. Methods: Plasma apoM concentration was determined using a sandwich ELISA with two monoclonal antibodies (CV < 5%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D-3-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling. Results: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL cholesterol and HDL cholesterol (p < 0.05). There were no associations between plasma apoM and plasma triglyceride, NEFA, insulin, glucose, HOMA... (More)
Objective: The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men. Methods: Plasma apoM concentration was determined using a sandwich ELISA with two monoclonal antibodies (CV < 5%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D-3-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling. Results: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL cholesterol and HDL cholesterol (p < 0.05). There were no associations between plasma apoM and plasma triglyceride, NEFA, insulin, glucose, HOMA score or adiponectin concentrations. Plasma apoM was positively associated with both apoA-I and apoA-II concentrations (r = 0.406, p < 0.01 and r = 0.510, p < 0.01, respectively) and negatively associated with HDL apoA-I and apoA-II fractional catabolic rate (FCR) (r = -0.291, p = 0.03 and r = -0.291, p = 0.026, respectively). No significant associations were observed between plasma apoM and HDL apoA-I and apoA-II production rate. In multivariate regression models, both plasma apoM and triglycerides were significant, independent predictors of HDL apoA-I FCR (adjusted R-2 = 16%, p < 0.01) and HDL apoA-II FCR (adjusted R-2 = 14%, p < 0.01). Conclusion: ApoM may be a significant, independent predictor of HDL apoA-I and apoA-II catabolism in overweight-obese, insulin resistant men. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Metabolic syndrome, Obesity, apoM, Kinetics
in
Atherosclerosis
volume
210
issue
1
pages
326 - 330
publisher
Elsevier
external identifiers
  • wos:000277085300054
  • scopus:77952420904
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2009.11.024
language
English
LU publication?
yes
id
6d8509ac-b33e-4963-984a-51947726927f (old id 1619550)
date added to LUP
2010-06-18 11:32:31
date last changed
2018-05-29 10:02:25
@article{6d8509ac-b33e-4963-984a-51947726927f,
  abstract     = {Objective: The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men. Methods: Plasma apoM concentration was determined using a sandwich ELISA with two monoclonal antibodies (CV &lt; 5%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D-3-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling. Results: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL cholesterol and HDL cholesterol (p &lt; 0.05). There were no associations between plasma apoM and plasma triglyceride, NEFA, insulin, glucose, HOMA score or adiponectin concentrations. Plasma apoM was positively associated with both apoA-I and apoA-II concentrations (r = 0.406, p &lt; 0.01 and r = 0.510, p &lt; 0.01, respectively) and negatively associated with HDL apoA-I and apoA-II fractional catabolic rate (FCR) (r = -0.291, p = 0.03 and r = -0.291, p = 0.026, respectively). No significant associations were observed between plasma apoM and HDL apoA-I and apoA-II production rate. In multivariate regression models, both plasma apoM and triglycerides were significant, independent predictors of HDL apoA-I FCR (adjusted R-2 = 16%, p &lt; 0.01) and HDL apoA-II FCR (adjusted R-2 = 14%, p &lt; 0.01). Conclusion: ApoM may be a significant, independent predictor of HDL apoA-I and apoA-II catabolism in overweight-obese, insulin resistant men. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.},
  author       = {Ooi, Esther M. M. and Watts, Gerald F. and Chan, Dick C. and Nielsen, Lars B. and Plomgaard, Peter and Dahlbäck, Björn and Barrett, P. Hugh R.},
  issn         = {1879-1484},
  keyword      = {Metabolic syndrome,Obesity,apoM,Kinetics},
  language     = {eng},
  number       = {1},
  pages        = {326--330},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2009.11.024},
  volume       = {210},
  year         = {2010},
}