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Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men

Ooi, Esther M. M. ; Watts, Gerald F. ; Chan, Dick C. ; Nielsen, Lars B. ; Plomgaard, Peter ; Dahlbäck, Björn LU and Barrett, P. Hugh R. (2010) In Atherosclerosis 210(1). p.326-330
Abstract
Objective: The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men. Methods: Plasma apoM concentration was determined using a sandwich ELISA with two monoclonal antibodies (CV < 5%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D-3-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling. Results: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL cholesterol and HDL cholesterol (p < 0.05). There were no associations between plasma apoM and plasma triglyceride, NEFA, insulin, glucose, HOMA... (More)
Objective: The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men. Methods: Plasma apoM concentration was determined using a sandwich ELISA with two monoclonal antibodies (CV < 5%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D-3-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling. Results: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL cholesterol and HDL cholesterol (p < 0.05). There were no associations between plasma apoM and plasma triglyceride, NEFA, insulin, glucose, HOMA score or adiponectin concentrations. Plasma apoM was positively associated with both apoA-I and apoA-II concentrations (r = 0.406, p < 0.01 and r = 0.510, p < 0.01, respectively) and negatively associated with HDL apoA-I and apoA-II fractional catabolic rate (FCR) (r = -0.291, p = 0.03 and r = -0.291, p = 0.026, respectively). No significant associations were observed between plasma apoM and HDL apoA-I and apoA-II production rate. In multivariate regression models, both plasma apoM and triglycerides were significant, independent predictors of HDL apoA-I FCR (adjusted R-2 = 16%, p < 0.01) and HDL apoA-II FCR (adjusted R-2 = 14%, p < 0.01). Conclusion: ApoM may be a significant, independent predictor of HDL apoA-I and apoA-II catabolism in overweight-obese, insulin resistant men. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Metabolic syndrome, Obesity, apoM, Kinetics
in
Atherosclerosis
volume
210
issue
1
pages
326 - 330
publisher
Elsevier
external identifiers
  • wos:000277085300054
  • scopus:77952420904
  • pmid:20031132
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2009.11.024
language
English
LU publication?
yes
id
6d8509ac-b33e-4963-984a-51947726927f (old id 1619550)
date added to LUP
2016-04-01 10:58:38
date last changed
2023-08-31 16:01:02
@article{6d8509ac-b33e-4963-984a-51947726927f,
  abstract     = {{Objective: The aim of this study was to investigate associations between plasma apoM concentration and HDL apoA-I and apoA-II kinetics in 60 overweight-obese, insulin resistant men. Methods: Plasma apoM concentration was determined using a sandwich ELISA with two monoclonal antibodies (CV &lt; 5%). The kinetics of HDL apoA-I and apoA-II were measured using intravenous administration of D-3-leucine, gas chromatography-mass spectrometry and multi-compartmental modeling. Results: Plasma apoM was inversely associated with body mass index and positively associated with plasma total cholesterol, LDL cholesterol and HDL cholesterol (p &lt; 0.05). There were no associations between plasma apoM and plasma triglyceride, NEFA, insulin, glucose, HOMA score or adiponectin concentrations. Plasma apoM was positively associated with both apoA-I and apoA-II concentrations (r = 0.406, p &lt; 0.01 and r = 0.510, p &lt; 0.01, respectively) and negatively associated with HDL apoA-I and apoA-II fractional catabolic rate (FCR) (r = -0.291, p = 0.03 and r = -0.291, p = 0.026, respectively). No significant associations were observed between plasma apoM and HDL apoA-I and apoA-II production rate. In multivariate regression models, both plasma apoM and triglycerides were significant, independent predictors of HDL apoA-I FCR (adjusted R-2 = 16%, p &lt; 0.01) and HDL apoA-II FCR (adjusted R-2 = 14%, p &lt; 0.01). Conclusion: ApoM may be a significant, independent predictor of HDL apoA-I and apoA-II catabolism in overweight-obese, insulin resistant men. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.}},
  author       = {{Ooi, Esther M. M. and Watts, Gerald F. and Chan, Dick C. and Nielsen, Lars B. and Plomgaard, Peter and Dahlbäck, Björn and Barrett, P. Hugh R.}},
  issn         = {{1879-1484}},
  keywords     = {{Metabolic syndrome; Obesity; apoM; Kinetics}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{326--330}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Association of apolipoprotein M with high-density lipoprotein kinetics in overweight-obese men}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2009.11.024}},
  doi          = {{10.1016/j.atherosclerosis.2009.11.024}},
  volume       = {{210}},
  year         = {{2010}},
}