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The role of low grade inflammation as measured by C-reactive protein levels in the explanation of socioeconomic differences in carotid atherosclerosis.

Rosvall, Maria LU ; Engström, Gunnar LU ; Janzon, Lars LU ; Berglund, Göran LU and Hedblad, Bo LU (2007) In European Journal of Public Health 17(4). p.340-347
Abstract
Background: The role of inflammation as part of the explanation of socioeconomic differences in carotid atherosclerosis has not been specifically investigated. Methods and Results: The associations between socioeconomic position (SEP), C-reactive protein (CRP), and preclinical carotid atherosclerosis were investigated in a general population sample of 3921 middle-aged Swedish men and women. Common carotid intima-media thickness (IMT) and presence of carotid plaque (focal IMT > 1.2 mm) were determined by B-mode ultrasound. The results showed that low SEP was associated with increased levels of CRP, independently of established risk factors. Furthermore, common carotid IMT increased with increasing CRP-levels. Presence of carotid plaque... (More)
Background: The role of inflammation as part of the explanation of socioeconomic differences in carotid atherosclerosis has not been specifically investigated. Methods and Results: The associations between socioeconomic position (SEP), C-reactive protein (CRP), and preclinical carotid atherosclerosis were investigated in a general population sample of 3921 middle-aged Swedish men and women. Common carotid intima-media thickness (IMT) and presence of carotid plaque (focal IMT > 1.2 mm) were determined by B-mode ultrasound. The results showed that low SEP was associated with increased levels of CRP, independently of established risk factors. Furthermore, common carotid IMT increased with increasing CRP-levels. Presence of carotid plaque increased with increasing CRP-levels in men, but not in women. While the socioeconomic differences in carotid IMT were weak, there were associations between low educational level and carotid plaque prevalence with an age- and sex-adjusted odds ratio (OR) of 1.39 (95% Cl: 1.21, 1.59). A similar association was seen for having a manual occupation, OR = 1.23 (95% Cl: 1.07, 1.42). The age- and sex-adjusted absolute differences in carotid plaque prevalence were 9% with regard to educational level and 7% with regard to occupational status. Adjustment for CRP caused only a minor attenuation of the association between SEP and carotid atherosclerosis. Conclusions: The association between SEP and carotid atherosclerosis as measured by carotid IMT and carotid plaque could only to a minor extent be referred to differences in low grade inflammation as measured by CRP. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
socioeconomic, carotid arteries, atherosclerosis, c-reactive protein, position
in
European Journal of Public Health
volume
17
issue
4
pages
340 - 347
publisher
Oxford University Press
external identifiers
  • wos:000249370300006
  • scopus:34547780499
ISSN
1101-1262
DOI
10.1093/eurpub/ckl247
language
English
LU publication?
yes
id
f4f9ce93-eca6-4204-bad2-d4e3961ba6b8 (old id 162093)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17068002&dopt=Abstract
date added to LUP
2007-07-30 13:48:35
date last changed
2017-07-30 03:34:35
@article{f4f9ce93-eca6-4204-bad2-d4e3961ba6b8,
  abstract     = {Background: The role of inflammation as part of the explanation of socioeconomic differences in carotid atherosclerosis has not been specifically investigated. Methods and Results: The associations between socioeconomic position (SEP), C-reactive protein (CRP), and preclinical carotid atherosclerosis were investigated in a general population sample of 3921 middle-aged Swedish men and women. Common carotid intima-media thickness (IMT) and presence of carotid plaque (focal IMT > 1.2 mm) were determined by B-mode ultrasound. The results showed that low SEP was associated with increased levels of CRP, independently of established risk factors. Furthermore, common carotid IMT increased with increasing CRP-levels. Presence of carotid plaque increased with increasing CRP-levels in men, but not in women. While the socioeconomic differences in carotid IMT were weak, there were associations between low educational level and carotid plaque prevalence with an age- and sex-adjusted odds ratio (OR) of 1.39 (95% Cl: 1.21, 1.59). A similar association was seen for having a manual occupation, OR = 1.23 (95% Cl: 1.07, 1.42). The age- and sex-adjusted absolute differences in carotid plaque prevalence were 9% with regard to educational level and 7% with regard to occupational status. Adjustment for CRP caused only a minor attenuation of the association between SEP and carotid atherosclerosis. Conclusions: The association between SEP and carotid atherosclerosis as measured by carotid IMT and carotid plaque could only to a minor extent be referred to differences in low grade inflammation as measured by CRP.},
  author       = {Rosvall, Maria and Engström, Gunnar and Janzon, Lars and Berglund, Göran and Hedblad, Bo},
  issn         = {1101-1262},
  keyword      = {socioeconomic,carotid arteries,atherosclerosis,c-reactive protein,position},
  language     = {eng},
  number       = {4},
  pages        = {340--347},
  publisher    = {Oxford University Press},
  series       = {European Journal of Public Health},
  title        = {The role of low grade inflammation as measured by C-reactive protein levels in the explanation of socioeconomic differences in carotid atherosclerosis.},
  url          = {http://dx.doi.org/10.1093/eurpub/ckl247},
  volume       = {17},
  year         = {2007},
}