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In Vitro Activity of Lipopeptides Pal-Lys-Lys-NH2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-positive Cocci.

Kamysz, Wojciech; Silvestri, Carmela; Cirioni, Oscar; Giacometti, Andrea; Licci, Alberto; Vittoria, Agnese Della; Okroj, Marcin LU and Scalise, Giorgio (2007) In Antimicrobial Agents and Chemotherapy 51(1). p.354-358
Abstract
The in vitro activities of the lipopeptides pahnitoyl (Pal)-Lys-Lys-NH2 and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Antimicrobial Agents and Chemotherapy
volume
51
issue
1
pages
354 - 358
publisher
American Society for Microbiology
external identifiers
  • wos:000243214200048
  • scopus:33845984047
ISSN
1098-6596
DOI
10.1128/AAC.00344-06
language
English
LU publication?
yes
id
b3b4e5a2-fad5-439c-8a51-051656b92dfc (old id 162162)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17060532&dopt=Abstract
date added to LUP
2007-07-25 14:38:05
date last changed
2017-09-03 04:26:59
@article{b3b4e5a2-fad5-439c-8a51-051656b92dfc,
  abstract     = {The in vitro activities of the lipopeptides pahnitoyl (Pal)-Lys-Lys-NH2 and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.},
  author       = {Kamysz, Wojciech and Silvestri, Carmela and Cirioni, Oscar and Giacometti, Andrea and Licci, Alberto and Vittoria, Agnese Della and Okroj, Marcin and Scalise, Giorgio},
  issn         = {1098-6596},
  language     = {eng},
  number       = {1},
  pages        = {354--358},
  publisher    = {American Society for Microbiology},
  series       = {Antimicrobial Agents and Chemotherapy},
  title        = {In Vitro Activity of Lipopeptides Pal-Lys-Lys-NH2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-positive Cocci.},
  url          = {http://dx.doi.org/10.1128/AAC.00344-06},
  volume       = {51},
  year         = {2007},
}