Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless
Baeg, Gyeong-Hun ; Lin, Xinhua ; Khare, Narmada ; Baumgartner, Stefan LU
and Perrimon, Norbert
(2001)
In Development: For advances in developmental biology and stem cells
128(1).
p.87-94
- Abstract
- Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays; a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper... (More)
- Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays; a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper glycosaminoglycan biosynthesis. We conclude that HSPGs play an important role in organizing the extracellular distribution of Wg. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119707
- author
- Baeg, Gyeong-Hun
; Lin, Xinhua
; Khare, Narmada
; Baumgartner, Stefan
LU
and Perrimon, Norbert
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Drosophila melanogaster, Morphogen, HSPG, Wg signaling
- in
- Development: For advances in developmental biology and stem cells
- volume
- 128
- issue
- 1
- pages
- 87 - 94
- publisher
- The Company of Biologists Ltd
- external identifiers
-
- wos:000166452100009
- scopus:0035152025
- ISSN
- 1477-9129
- language
- English
- LU publication?
- yes
- id
- 162251f7-7d21-4b4a-b152-ecb2cb311963 (old id 1119707)
- alternative location
- http://dev.biologists.org/content/128/1/87.abstract
- date added to LUP
- 2016-04-01 12:12:56
- date last changed
- 2022-03-13 06:55:54
@article{162251f7-7d21-4b4a-b152-ecb2cb311963,
abstract = {{Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activity implicates a function for DLY in Wg reception and we show that overexpression of DLY leads to an accumulation of extracellular Wg. We propose that DLY plays; a role in the extracellular distribution of Wg. Consistent with this model, a dramatic decrease of extracellular Wg was detected in clones of cells that are deficient in proper glycosaminoglycan biosynthesis. We conclude that HSPGs play an important role in organizing the extracellular distribution of Wg.}},
author = {{Baeg, Gyeong-Hun and Lin, Xinhua and Khare, Narmada and Baumgartner, Stefan and Perrimon, Norbert}},
issn = {{1477-9129}},
keywords = {{Drosophila
melanogaster; Morphogen; HSPG; Wg signaling}},
language = {{eng}},
number = {{1}},
pages = {{87--94}},
publisher = {{The Company of Biologists Ltd}},
series = {{Development: For advances in developmental biology and stem cells}},
title = {{Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless}},
url = {{http://dev.biologists.org/content/128/1/87.abstract}},
volume = {{128}},
year = {{2001}},
}