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Plasma Adiponectin Levels in Relation to Carotid Intima Media Thickness and Markers of Insulin Resistance.

Nilsson, Peter LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Frystyk, Jan ; Persson, Margaretha LU orcid ; Berglund, Göran LU and Flyvbjerg, Allan (2006) In Arteriosclerosis, Thrombosis and Vascular Biology 26(12). p.2758-2762
Abstract
Background - Circulating adiponectin is a marker for insulin sensitivity, derived from fat cells. It is largely unknown if adiponectin is also an independent marker for early atherosclerosis. Methods and Results - Plasma adiponectin levels were measured in 373 men and 514 women of middle-age by a time-resolved immunofluorometric assay. The subjects were sampled stratified for degree of insulin sensitivity (HOMA-IR). An ultrasound measurement of the right common carotid artery intima media thickness (IMT) was made. When the distribution of adiponectin was stratified into sex-specific quartiles (Q1 to Q4), men in Q4 differed from Q1 in higher mean age and high-density lipoprotein (HDL) cholesterol, but lower blood pressure, HbA(1c),... (More)
Background - Circulating adiponectin is a marker for insulin sensitivity, derived from fat cells. It is largely unknown if adiponectin is also an independent marker for early atherosclerosis. Methods and Results - Plasma adiponectin levels were measured in 373 men and 514 women of middle-age by a time-resolved immunofluorometric assay. The subjects were sampled stratified for degree of insulin sensitivity (HOMA-IR). An ultrasound measurement of the right common carotid artery intima media thickness (IMT) was made. When the distribution of adiponectin was stratified into sex-specific quartiles (Q1 to Q4), men in Q4 differed from Q1 in higher mean age and high-density lipoprotein (HDL) cholesterol, but lower blood pressure, HbA(1c), HOMA-index, and body mass index. Women showed similar associations. Mean IMT for men was significantly lower (P = 0.03) in adiponectin Q4 as compared with Q1 when adjusted for age, waist, smoking, HDL cholesterol, and diastolic blood pressure. When adding HbA1c and HOMA to the model, the association was no longer significant (P = 0.15). In women no difference in IMT was noticed across adiponectin quartiles. Conclusion - Plasma adiponectin is a marker of glucose metabolism and obesity and shows an inverse age-adjusted association with carotid ultrasound IMT in men, but not in women. This association is attenuated after adjustments for other risk factors. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
obesity, insulin, IMT, glucose, atherosclerosis, adiponectin
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
26
issue
12
pages
2758 - 2762
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000243566100027
  • scopus:33751191630
  • pmid:17038635
ISSN
1524-4636
DOI
10.1161/01.ATV.0000249638.01416.4b
language
English
LU publication?
yes
id
9d764029-3942-4f84-acc4-d0dfa23deb98 (old id 162342)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17038635&dopt=Abstract
date added to LUP
2016-04-01 12:05:06
date last changed
2021-05-05 02:28:46
@article{9d764029-3942-4f84-acc4-d0dfa23deb98,
  abstract     = {Background - Circulating adiponectin is a marker for insulin sensitivity, derived from fat cells. It is largely unknown if adiponectin is also an independent marker for early atherosclerosis. Methods and Results - Plasma adiponectin levels were measured in 373 men and 514 women of middle-age by a time-resolved immunofluorometric assay. The subjects were sampled stratified for degree of insulin sensitivity (HOMA-IR). An ultrasound measurement of the right common carotid artery intima media thickness (IMT) was made. When the distribution of adiponectin was stratified into sex-specific quartiles (Q1 to Q4), men in Q4 differed from Q1 in higher mean age and high-density lipoprotein (HDL) cholesterol, but lower blood pressure, HbA(1c), HOMA-index, and body mass index. Women showed similar associations. Mean IMT for men was significantly lower (P = 0.03) in adiponectin Q4 as compared with Q1 when adjusted for age, waist, smoking, HDL cholesterol, and diastolic blood pressure. When adding HbA1c and HOMA to the model, the association was no longer significant (P = 0.15). In women no difference in IMT was noticed across adiponectin quartiles. Conclusion - Plasma adiponectin is a marker of glucose metabolism and obesity and shows an inverse age-adjusted association with carotid ultrasound IMT in men, but not in women. This association is attenuated after adjustments for other risk factors.},
  author       = {Nilsson, Peter and Engström, Gunnar and Hedblad, Bo and Frystyk, Jan and Persson, Margaretha and Berglund, Göran and Flyvbjerg, Allan},
  issn         = {1524-4636},
  language     = {eng},
  number       = {12},
  pages        = {2758--2762},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Plasma Adiponectin Levels in Relation to Carotid Intima Media Thickness and Markers of Insulin Resistance.},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000249638.01416.4b},
  doi          = {10.1161/01.ATV.0000249638.01416.4b},
  volume       = {26},
  year         = {2006},
}