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Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis.

Berkestedt, Ingrid LU ; Herwald, Heiko LU ; Ljunggren, Lennart; Nelson, Axel LU and Bodelsson, Mikael LU (2010) In Journal of Innate Immunity 2(5). p.478-482
Abstract
We wanted to investigate if plasma levels of antimicrobial polypeptides (AMPs) are increased in severe sepsis and if they correlate with severity and mortality. Samples were collected from 31 sepsis patients at the intensive care unit. The Sequential Organ Failure Assessment (SOFA) score and 90-day mortality were registered, and inflammatory markers and AMP levels were measured by ELISA. A median SOFA score (13) and cardiovascular SOFA score (3) indicated multiorgan failure with severe circulatory derangement, and elevated cytokine levels indicated inflammatory activation. Levels of bactericidal/permeability-increasing protein, heparin-binding protein, alpha-defensins and lactoferrin but not LL-37 were elevated in sepsis patients compared... (More)
We wanted to investigate if plasma levels of antimicrobial polypeptides (AMPs) are increased in severe sepsis and if they correlate with severity and mortality. Samples were collected from 31 sepsis patients at the intensive care unit. The Sequential Organ Failure Assessment (SOFA) score and 90-day mortality were registered, and inflammatory markers and AMP levels were measured by ELISA. A median SOFA score (13) and cardiovascular SOFA score (3) indicated multiorgan failure with severe circulatory derangement, and elevated cytokine levels indicated inflammatory activation. Levels of bactericidal/permeability-increasing protein, heparin-binding protein, alpha-defensins and lactoferrin but not LL-37 were elevated in sepsis patients compared with controls. Bactericidal/permeability-increasing protein levels correlated with mortality, with lower levels in survivors. Levels of all AMPs, except LL-37, positively correlated with the cardiovascular SOFA score. In conclusion, levels of several AMPs are increased in sepsis and correlate with circulatory derangement. This probably reflects neutrophil activation as part of an innate immune response. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Innate Immunity
volume
2
issue
5
pages
478 - 482
publisher
Karger
external identifiers
  • wos:000281211300011
  • pmid:20571257
  • scopus:77956055988
ISSN
1662-811X
DOI
10.1159/000317036
language
English
LU publication?
yes
id
18dcb400-e303-4c25-9f95-6f7fbe8a4979 (old id 1625789)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20571257?dopt=Abstract
date added to LUP
2010-07-05 21:14:06
date last changed
2018-05-29 09:51:11
@article{18dcb400-e303-4c25-9f95-6f7fbe8a4979,
  abstract     = {We wanted to investigate if plasma levels of antimicrobial polypeptides (AMPs) are increased in severe sepsis and if they correlate with severity and mortality. Samples were collected from 31 sepsis patients at the intensive care unit. The Sequential Organ Failure Assessment (SOFA) score and 90-day mortality were registered, and inflammatory markers and AMP levels were measured by ELISA. A median SOFA score (13) and cardiovascular SOFA score (3) indicated multiorgan failure with severe circulatory derangement, and elevated cytokine levels indicated inflammatory activation. Levels of bactericidal/permeability-increasing protein, heparin-binding protein, alpha-defensins and lactoferrin but not LL-37 were elevated in sepsis patients compared with controls. Bactericidal/permeability-increasing protein levels correlated with mortality, with lower levels in survivors. Levels of all AMPs, except LL-37, positively correlated with the cardiovascular SOFA score. In conclusion, levels of several AMPs are increased in sepsis and correlate with circulatory derangement. This probably reflects neutrophil activation as part of an innate immune response.},
  author       = {Berkestedt, Ingrid and Herwald, Heiko and Ljunggren, Lennart and Nelson, Axel and Bodelsson, Mikael},
  issn         = {1662-811X},
  language     = {eng},
  number       = {5},
  pages        = {478--482},
  publisher    = {Karger},
  series       = {Journal of Innate Immunity},
  title        = {Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis.},
  url          = {http://dx.doi.org/10.1159/000317036},
  volume       = {2},
  year         = {2010},
}