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Gelatine-embedded electrodes-a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes.

Lind, Gustav LU ; Eriksson Linsmeier, Cecilia LU ; Thelin, Jonas LU and Schouenborg, Jens LU (2010) In Journal of Neural Engineering 7(4).
Abstract
Chronic neural interfaces that are both structurally and functionally stable inside the brain over years or decades hold great promise to become an invaluable clinical tool in the near future. A key flaw in the current electrode interfaces is that their recording capabilities deteriorate over time, possibly due to the lack of flexibility, which causes movements in relation to the neural tissue that result in small inflammations and loss of electrode function. We have developed a new neural probe using the stabilizing property of gelatine that allows the implantation of ultra-thin and flexible electrodes into the central nervous system. The microglial and astrocytic reactions evoked by implanted gelatine needles, as well as the wire bundles... (More)
Chronic neural interfaces that are both structurally and functionally stable inside the brain over years or decades hold great promise to become an invaluable clinical tool in the near future. A key flaw in the current electrode interfaces is that their recording capabilities deteriorate over time, possibly due to the lack of flexibility, which causes movements in relation to the neural tissue that result in small inflammations and loss of electrode function. We have developed a new neural probe using the stabilizing property of gelatine that allows the implantation of ultra-thin and flexible electrodes into the central nervous system. The microglial and astrocytic reactions evoked by implanted gelatine needles, as well as the wire bundles in combination with gelatine, were investigated using immunohistochemistry and fluorescence microscopy up to 12 weeks after implantation. The results indicate that pure gelatine needles were stiff enough to penetrate the brain tissue on their own, and evoked a significantly smaller chronic scar than stab wounds. Moreover, gelatine embedding appeared to reduce the acute reactions caused by the implants and we found no adverse effects of gelatine or gelatine-embedded electrodes. Successful electrophysiological recordings were made from very thin electrodes implanted in this fashion. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Neural Engineering
volume
7
issue
4
publisher
IOP Publishing
external identifiers
  • wos:000280038600009
  • pmid:20551508
  • scopus:78549231632
ISSN
1741-2560
DOI
10.1088/1741-2560/7/4/046005
language
English
LU publication?
yes
id
ecb211f3-eafe-4729-a0c8-a495db49ee4c (old id 1626007)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20551508?dopt=Abstract
date added to LUP
2010-07-05 20:03:26
date last changed
2018-06-03 04:32:32
@article{ecb211f3-eafe-4729-a0c8-a495db49ee4c,
  abstract     = {Chronic neural interfaces that are both structurally and functionally stable inside the brain over years or decades hold great promise to become an invaluable clinical tool in the near future. A key flaw in the current electrode interfaces is that their recording capabilities deteriorate over time, possibly due to the lack of flexibility, which causes movements in relation to the neural tissue that result in small inflammations and loss of electrode function. We have developed a new neural probe using the stabilizing property of gelatine that allows the implantation of ultra-thin and flexible electrodes into the central nervous system. The microglial and astrocytic reactions evoked by implanted gelatine needles, as well as the wire bundles in combination with gelatine, were investigated using immunohistochemistry and fluorescence microscopy up to 12 weeks after implantation. The results indicate that pure gelatine needles were stiff enough to penetrate the brain tissue on their own, and evoked a significantly smaller chronic scar than stab wounds. Moreover, gelatine embedding appeared to reduce the acute reactions caused by the implants and we found no adverse effects of gelatine or gelatine-embedded electrodes. Successful electrophysiological recordings were made from very thin electrodes implanted in this fashion.},
  articleno    = {046005},
  author       = {Lind, Gustav and Eriksson Linsmeier, Cecilia and Thelin, Jonas and Schouenborg, Jens},
  issn         = {1741-2560},
  language     = {eng},
  number       = {4},
  publisher    = {IOP Publishing},
  series       = {Journal of Neural Engineering},
  title        = {Gelatine-embedded electrodes-a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes.},
  url          = {http://dx.doi.org/10.1088/1741-2560/7/4/046005},
  volume       = {7},
  year         = {2010},
}