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Monitoring of low molecular weight heparin anticoagulation during haemodialysis with a Sonoclot Analyzer.

Schött, Ulf LU ; Nilsson, Lars Göran; Broman, Marcus and Engström, Martin LU (2010) In Perfusion Jul 1. p.191-196
Abstract
Objectives: Sonoclot was used in this study to monitor low molecular weight heparin (LMWH) during haemodialysis. Material and Methods: Two different intravenous doses (standard / half-dose) of dalteparin were studied in eight patients. Blood was sampled for coagulation analyses with Sonoclot, thrombin-antithrombin (TAT) and anti-Xa. A visual fibrin deposition score (VFS) in the venous drip chamber was also evaluated. RESULTS: All patients completed their dialysis. There was a progressive increase in TAT levels, which correlated to the dalteparin dose. Significant differences (p<0.05) were found for TAT, VFS and Sonoclot celite-activated clotting time (SonACT) between the different LMWH dosages. TAT and Sonoclot correlated to each other,... (More)
Objectives: Sonoclot was used in this study to monitor low molecular weight heparin (LMWH) during haemodialysis. Material and Methods: Two different intravenous doses (standard / half-dose) of dalteparin were studied in eight patients. Blood was sampled for coagulation analyses with Sonoclot, thrombin-antithrombin (TAT) and anti-Xa. A visual fibrin deposition score (VFS) in the venous drip chamber was also evaluated. RESULTS: All patients completed their dialysis. There was a progressive increase in TAT levels, which correlated to the dalteparin dose. Significant differences (p<0.05) were found for TAT, VFS and Sonoclot celite-activated clotting time (SonACT) between the different LMWH dosages. TAT and Sonoclot correlated to each other, but not to the VFS. SonACT was significantly increased at two hours, with the high dalteparin dose compared to the lower dose. CONCLUSION: Both Sonoclot and TAT failed to predict the VFS. No patient had any clinical clotting events and all dialyses were completed successfully. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Perfusion
volume
Jul 1
pages
191 - 196
publisher
SAGE Publications Inc.
external identifiers
  • wos:000280750500002
  • pmid:20530518
  • scopus:77955777586
ISSN
1477-111X
DOI
10.1177/0267659110374675
language
English
LU publication?
yes
id
3383f5a4-06dc-42f7-bb96-0a936bd43173 (old id 1626278)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20530518?dopt=Abstract
date added to LUP
2010-07-05 10:14:43
date last changed
2017-01-01 07:53:41
@article{3383f5a4-06dc-42f7-bb96-0a936bd43173,
  abstract     = {Objectives: Sonoclot was used in this study to monitor low molecular weight heparin (LMWH) during haemodialysis. Material and Methods: Two different intravenous doses (standard / half-dose) of dalteparin were studied in eight patients. Blood was sampled for coagulation analyses with Sonoclot, thrombin-antithrombin (TAT) and anti-Xa. A visual fibrin deposition score (VFS) in the venous drip chamber was also evaluated. RESULTS: All patients completed their dialysis. There was a progressive increase in TAT levels, which correlated to the dalteparin dose. Significant differences (p&lt;0.05) were found for TAT, VFS and Sonoclot celite-activated clotting time (SonACT) between the different LMWH dosages. TAT and Sonoclot correlated to each other, but not to the VFS. SonACT was significantly increased at two hours, with the high dalteparin dose compared to the lower dose. CONCLUSION: Both Sonoclot and TAT failed to predict the VFS. No patient had any clinical clotting events and all dialyses were completed successfully.},
  author       = {Schött, Ulf and Nilsson, Lars Göran and Broman, Marcus and Engström, Martin},
  issn         = {1477-111X},
  language     = {eng},
  pages        = {191--196},
  publisher    = {SAGE Publications Inc.},
  series       = {Perfusion},
  title        = {Monitoring of low molecular weight heparin anticoagulation during haemodialysis with a Sonoclot Analyzer.},
  url          = {http://dx.doi.org/10.1177/0267659110374675},
  volume       = {Jul 1},
  year         = {2010},
}