Chronic pancreatitis: potential future interventions.
Ansari, Daniel LU ; Andersson, Ellen LU ; Andersson, Bodil LU
and Andersson, Roland
LU
(2010)
In Scandinavian Journal of Gastroenterology
45(9).
p.1022-1028
- Abstract
- Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms still are incompletely understood. In the last decade, increasing evidence has shown that activated pancreatic stellate cells play a key role in the fibrosis development associated with chronic pancreatitis as well as pancreatic cancer. During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins. Hitherto, specific therapies to prevent or reverse pancreatic fibrosis are unavailable. This review addresses current insights into pathological mechanisms underlying chronic pancreatitis and their... (More)
- Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms still are incompletely understood. In the last decade, increasing evidence has shown that activated pancreatic stellate cells play a key role in the fibrosis development associated with chronic pancreatitis as well as pancreatic cancer. During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins. Hitherto, specific therapies to prevent or reverse pancreatic fibrosis are unavailable. This review addresses current insights into pathological mechanisms underlying chronic pancreatitis and their applicability as concerns the development of potential future therapeutic approaches. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1626544
- author
- Ansari, Daniel
LU
; Andersson, Ellen
LU
; Andersson, Bodil
LU
and Andersson, Roland
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- * Chronic: physiopathology * Chronic: therapy * Pancreatitis
- in
- Scandinavian Journal of Gastroenterology
- volume
- 45
- issue
- 9
- pages
- 1022 - 1028
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000282143800003
- pmid:20509755
- scopus:77955547735
- pmid:20509755
- ISSN
- 1502-7708
- DOI
- 10.3109/00365521003734174
- language
- English
- LU publication?
- yes
- id
- 22397f0d-ead9-494c-bff3-305a03c6c108 (old id 1626544)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20509755?dopt=Abstract
- date added to LUP
- 2016-04-04 09:34:08
- date last changed
- 2022-02-21 01:25:25
@article{22397f0d-ead9-494c-bff3-305a03c6c108,
abstract = {{Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms still are incompletely understood. In the last decade, increasing evidence has shown that activated pancreatic stellate cells play a key role in the fibrosis development associated with chronic pancreatitis as well as pancreatic cancer. During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins. Hitherto, specific therapies to prevent or reverse pancreatic fibrosis are unavailable. This review addresses current insights into pathological mechanisms underlying chronic pancreatitis and their applicability as concerns the development of potential future therapeutic approaches.}},
author = {{Ansari, Daniel and Andersson, Ellen and Andersson, Bodil and Andersson, Roland}},
issn = {{1502-7708}},
keywords = {{* Chronic: physiopathology * Chronic: therapy * Pancreatitis}},
language = {{eng}},
number = {{9}},
pages = {{1022--1028}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Chronic pancreatitis: potential future interventions.}},
url = {{http://dx.doi.org/10.3109/00365521003734174}},
doi = {{10.3109/00365521003734174}},
volume = {{45}},
year = {{2010}},
}