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Chronic pancreatitis: potential future interventions.

Ansari, Daniel LU ; Andersson, Ellen LU ; Andersson, Bodil LU and Andersson, Roland LU (2010) In Scandinavian Journal of Gastroenterology 45(9). p.1022-1028
Abstract
Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms still are incompletely understood. In the last decade, increasing evidence has shown that activated pancreatic stellate cells play a key role in the fibrosis development associated with chronic pancreatitis as well as pancreatic cancer. During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins. Hitherto, specific therapies to prevent or reverse pancreatic fibrosis are unavailable. This review addresses current insights into pathological mechanisms underlying chronic pancreatitis and their... (More)
Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms still are incompletely understood. In the last decade, increasing evidence has shown that activated pancreatic stellate cells play a key role in the fibrosis development associated with chronic pancreatitis as well as pancreatic cancer. During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins. Hitherto, specific therapies to prevent or reverse pancreatic fibrosis are unavailable. This review addresses current insights into pathological mechanisms underlying chronic pancreatitis and their applicability as concerns the development of potential future therapeutic approaches. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
* Chronic: physiopathology * Chronic: therapy * Pancreatitis
in
Scandinavian Journal of Gastroenterology
volume
45
issue
9
pages
1022 - 1028
publisher
Taylor & Francis
external identifiers
  • wos:000282143800003
  • pmid:20509755
  • scopus:77955547735
ISSN
1502-7708
DOI
10.3109/00365521003734174
language
English
LU publication?
yes
id
22397f0d-ead9-494c-bff3-305a03c6c108 (old id 1626544)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20509755?dopt=Abstract
date added to LUP
2010-07-05 21:45:40
date last changed
2017-01-01 07:51:19
@article{22397f0d-ead9-494c-bff3-305a03c6c108,
  abstract     = {Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms still are incompletely understood. In the last decade, increasing evidence has shown that activated pancreatic stellate cells play a key role in the fibrosis development associated with chronic pancreatitis as well as pancreatic cancer. During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins. Hitherto, specific therapies to prevent or reverse pancreatic fibrosis are unavailable. This review addresses current insights into pathological mechanisms underlying chronic pancreatitis and their applicability as concerns the development of potential future therapeutic approaches.},
  author       = {Ansari, Daniel and Andersson, Ellen and Andersson, Bodil and Andersson, Roland},
  issn         = {1502-7708},
  keyword      = {* Chronic: physiopathology * Chronic: therapy * Pancreatitis},
  language     = {eng},
  number       = {9},
  pages        = {1022--1028},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Chronic pancreatitis: potential future interventions.},
  url          = {http://dx.doi.org/10.3109/00365521003734174},
  volume       = {45},
  year         = {2010},
}