Advanced

Gonadal sex steroid status and bone health in middle-aged and elderly European men

Vanderschueren, D.; Pye, S. R.; Venken, K.; Borghs, H.; Gaytant, J.; Huhtaniemi, I. T.; Adams, J. E.; Ward, K. A.; Bartfai, G. and Casanueva, F. F., et al. (2010) In Osteoporosis International 21(8). p.1331-1339
Abstract
The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood... (More)
The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E-2), testosterone (T), free and bio-available E-2 and T and sex hormone binding globulin (SHBG). Serum total T was not associated with any of the QUS parameters. Free T and both free and total E-2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (< 60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E-2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Higher free and total E-2 are associated with bone health not only among the elderly but also middle-aged European men. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Testosterone, SHBG, Sex steroids, Epidemiology, Oestradiol, Ultrasound
in
Osteoporosis International
volume
21
issue
8
pages
1331 - 1339
publisher
Springer
external identifiers
  • wos:000279478500006
  • scopus:77954473461
ISSN
1433-2965
DOI
10.1007/s00198-009-1144-2
language
English
LU publication?
yes
id
e2c62a55-b5e5-4e42-89bc-c47d1aeed876 (old id 1628737)
date added to LUP
2010-07-21 16:29:21
date last changed
2018-05-29 09:41:29
@article{e2c62a55-b5e5-4e42-89bc-c47d1aeed876,
  abstract     = {The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E-2), testosterone (T), free and bio-available E-2 and T and sex hormone binding globulin (SHBG). Serum total T was not associated with any of the QUS parameters. Free T and both free and total E-2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (&lt; 60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E-2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Higher free and total E-2 are associated with bone health not only among the elderly but also middle-aged European men.},
  author       = {Vanderschueren, D. and Pye, S. R. and Venken, K. and Borghs, H. and Gaytant, J. and Huhtaniemi, I. T. and Adams, J. E. and Ward, K. A. and Bartfai, G. and Casanueva, F. F. and Finn, J. D. and Forti, G. and Giwercman, Aleksander and Han, T. S. and Kula, K. and Labrie, F. and Lean, M. E. J. and Pendleton, N. and Punab, M. and Silman, A. J. and Wu, F. C. W. and O'Neill, T. W. and Boonen, S.},
  issn         = {1433-2965},
  keyword      = {Testosterone,SHBG,Sex steroids,Epidemiology,Oestradiol,Ultrasound},
  language     = {eng},
  number       = {8},
  pages        = {1331--1339},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Gonadal sex steroid status and bone health in middle-aged and elderly European men},
  url          = {http://dx.doi.org/10.1007/s00198-009-1144-2},
  volume       = {21},
  year         = {2010},
}