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Vesicle-Templated Layer-by-Layer Assembly for the Production of Nanocapsules

Cuomo, Francesca; Lopez, Francesco; Miguel, Maria G. and Lindman, Björn LU (2010) In Langmuir 26(13). p.10555-10560
Abstract
Hollow structures on the submicrometer scale (urn) are obtained with the assembly of polyelectrolytes according to the layer-by-layer (LbL) technique. Following the LbL procedure, polymers alginate and chitosan were alternatively adsorbed on a vesicular template made of didodecyldimethylammonium bromide (DDAB). Evidence for the removal of the vesicular template entrapped in the alginate/chitosan film is presented. The removal of the vesicular template was achieved through interactions between a nonionic surfactant (Triton X100) and the double-chained surfactant forming the vesicles. The application of this approach allowed the production of hollow nanospheres with a mild procedure, avoiding the use of strong acids or other extreme working... (More)
Hollow structures on the submicrometer scale (urn) are obtained with the assembly of polyelectrolytes according to the layer-by-layer (LbL) technique. Following the LbL procedure, polymers alginate and chitosan were alternatively adsorbed on a vesicular template made of didodecyldimethylammonium bromide (DDAB). Evidence for the removal of the vesicular template entrapped in the alginate/chitosan film is presented. The removal of the vesicular template was achieved through interactions between a nonionic surfactant (Triton X100) and the double-chained surfactant forming the vesicles. The application of this approach allowed the production of hollow nanospheres with a mild procedure, avoiding the use of strong acids or other extreme working conditions that can modify the shell integrity. The obtained nanostructures were characterized by means of dynamic light scattering (DLS), the zeta potential, and scanning electron microscopy (SEM). The SEM analysis demonstrated the presence, after the core removal process, of nanocapsules indistinguishable in size and shape from the parent core shell system. The analysis of the surface charge of the hollow nanocapsules, after the core dissolution, by zeta potential measurements, indicates good aggregate stability. DLS measurements showed that the size of the nanocapsules is on the order of hundreds of nanometers. Moreover, the size of both the core-shell and the hollow particles did not appear to be perturbed by variations in temperature or ionic strength. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
26
issue
13
pages
10555 - 10560
publisher
The American Chemical Society
external identifiers
  • wos:000279239900024
  • scopus:77954259633
ISSN
0743-7463
DOI
10.1021/la100584b
language
English
LU publication?
yes
id
9ffe1ff6-895b-4869-977a-88f3e5ade71c (old id 1629002)
date added to LUP
2010-07-23 11:04:40
date last changed
2018-06-10 03:16:03
@article{9ffe1ff6-895b-4869-977a-88f3e5ade71c,
  abstract     = {Hollow structures on the submicrometer scale (urn) are obtained with the assembly of polyelectrolytes according to the layer-by-layer (LbL) technique. Following the LbL procedure, polymers alginate and chitosan were alternatively adsorbed on a vesicular template made of didodecyldimethylammonium bromide (DDAB). Evidence for the removal of the vesicular template entrapped in the alginate/chitosan film is presented. The removal of the vesicular template was achieved through interactions between a nonionic surfactant (Triton X100) and the double-chained surfactant forming the vesicles. The application of this approach allowed the production of hollow nanospheres with a mild procedure, avoiding the use of strong acids or other extreme working conditions that can modify the shell integrity. The obtained nanostructures were characterized by means of dynamic light scattering (DLS), the zeta potential, and scanning electron microscopy (SEM). The SEM analysis demonstrated the presence, after the core removal process, of nanocapsules indistinguishable in size and shape from the parent core shell system. The analysis of the surface charge of the hollow nanocapsules, after the core dissolution, by zeta potential measurements, indicates good aggregate stability. DLS measurements showed that the size of the nanocapsules is on the order of hundreds of nanometers. Moreover, the size of both the core-shell and the hollow particles did not appear to be perturbed by variations in temperature or ionic strength.},
  author       = {Cuomo, Francesca and Lopez, Francesco and Miguel, Maria G. and Lindman, Björn},
  issn         = {0743-7463},
  language     = {eng},
  number       = {13},
  pages        = {10555--10560},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {Vesicle-Templated Layer-by-Layer Assembly for the Production of Nanocapsules},
  url          = {http://dx.doi.org/10.1021/la100584b},
  volume       = {26},
  year         = {2010},
}