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No effect of obstetric complications on basal ganglia volumes in schizophrenia

Haukvik, Unn Kristin; McNeil, Thomas LU ; Nesvag, Ragnar; Soderman, Erik; Jonsson, Erik and Agartz, Ingrid (2010) In Progress in Neuro-Psychopharmacology and Biological Psychiatry 34(4). p.619-623
Abstract
Background: Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. Altered volumes of other brain structures (e.g. hippocampus and lateral ventricles) have been reported in schizophrenia patients with a history of obstetric complications (005). This is the first study to explore if there is a relationship between OCs and basal ganglia volume in schizophrenia. Methods: Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was... (More)
Background: Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. Altered volumes of other brain structures (e.g. hippocampus and lateral ventricles) have been reported in schizophrenia patients with a history of obstetric complications (005). This is the first study to explore if there is a relationship between OCs and basal ganglia volume in schizophrenia. Methods: Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was undertaken. MR images were obtained on a 1.5T scanner, and volumes of nucleus caudatus, globus pallidum, putamen, and nucleus accumbens were quantified automatically. Information on OCs was blindly collected from original birth records. Results: Unadjusted estimates demonstrated a relationship between increasing number of OCs and larger volume of nucleus accumbens in schizophrenia patients and healthy controls. No statistically significant relationships were found between OCs and the basal ganglia volumes when controlled for intracranial volume, age, and multiple comparisons. There were no effects of typical versus atypical medication on the basal ganglia volumes. The patients with schizophrenia had larger globus pallidum volumes as compared to healthy controls, but there were no case-control differences for accumbens, putamen, or caudate volumes. Conclusion: The present results do not support the hypothesis that OCs are related to alterations in basal ganglia volume in chronic schizophrenia. (C) 2010 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Schizophrenia, complications, Obstetric, Neurodevelopment, MRI, Basal ganglia, Dopamine
in
Progress in Neuro-Psychopharmacology and Biological Psychiatry
volume
34
issue
4
pages
619 - 623
publisher
Elsevier
external identifiers
  • wos:000278885700008
  • scopus:77952604428
ISSN
0278-5846
DOI
10.1016/j.pnpbp.2010.02.024
language
English
LU publication?
yes
id
7cc22861-e0b6-4cbe-86c3-2a5a30ea31d2 (old id 1630275)
date added to LUP
2010-07-22 14:50:10
date last changed
2018-05-29 09:31:24
@article{7cc22861-e0b6-4cbe-86c3-2a5a30ea31d2,
  abstract     = {Background: Heterogeneous findings have been reported in studies of basal ganglia volumes in schizophrenia patients as compared to healthy controls. The basal ganglia contain dopamine receptors that are known to be involved in schizophrenia pathology and to be vulnerable to pre- and perinatal hypoxic insults. Altered volumes of other brain structures (e.g. hippocampus and lateral ventricles) have been reported in schizophrenia patients with a history of obstetric complications (005). This is the first study to explore if there is a relationship between OCs and basal ganglia volume in schizophrenia. Methods: Thorough clinical investigation (including information on medication) of 54 schizophrenia patients and 54 healthy control subjects was undertaken. MR images were obtained on a 1.5T scanner, and volumes of nucleus caudatus, globus pallidum, putamen, and nucleus accumbens were quantified automatically. Information on OCs was blindly collected from original birth records. Results: Unadjusted estimates demonstrated a relationship between increasing number of OCs and larger volume of nucleus accumbens in schizophrenia patients and healthy controls. No statistically significant relationships were found between OCs and the basal ganglia volumes when controlled for intracranial volume, age, and multiple comparisons. There were no effects of typical versus atypical medication on the basal ganglia volumes. The patients with schizophrenia had larger globus pallidum volumes as compared to healthy controls, but there were no case-control differences for accumbens, putamen, or caudate volumes. Conclusion: The present results do not support the hypothesis that OCs are related to alterations in basal ganglia volume in chronic schizophrenia. (C) 2010 Elsevier Inc. All rights reserved.},
  author       = {Haukvik, Unn Kristin and McNeil, Thomas and Nesvag, Ragnar and Soderman, Erik and Jonsson, Erik and Agartz, Ingrid},
  issn         = {0278-5846},
  keyword      = {Schizophrenia,complications,Obstetric,Neurodevelopment,MRI,Basal ganglia,Dopamine},
  language     = {eng},
  number       = {4},
  pages        = {619--623},
  publisher    = {Elsevier},
  series       = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  title        = {No effect of obstetric complications on basal ganglia volumes in schizophrenia},
  url          = {http://dx.doi.org/10.1016/j.pnpbp.2010.02.024},
  volume       = {34},
  year         = {2010},
}