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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Mestdagh, P.; Fredlund, Erik LU ; Pattyn, F.; Rihani, A.; Van Maerken, T.; Vermeulen, J.; Kumps, C.; Menten, B.; De Preter, K. and Schramm, A., et al. (2010) In Oncogene 29(24). p.3583-3592
Abstract
Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular... (More)
Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010 (Less)
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publication status
published
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keywords
non-coding RNA, neuroblastoma, T-UCR
in
Oncogene
volume
29
issue
24
pages
3583 - 3592
publisher
Nature Publishing Group
external identifiers
  • wos:000278835400013
  • scopus:77953808788
ISSN
1476-5594
DOI
10.1038/onc.2010.106
language
English
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yes
id
965ae2c6-2556-4dc2-86e7-f99a715ccb6f (old id 1630286)
date added to LUP
2010-07-22 14:53:13
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2018-07-01 03:23:47
@article{965ae2c6-2556-4dc2-86e7-f99a715ccb6f,
  abstract     = {Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010},
  author       = {Mestdagh, P. and Fredlund, Erik and Pattyn, F. and Rihani, A. and Van Maerken, T. and Vermeulen, J. and Kumps, C. and Menten, B. and De Preter, K. and Schramm, A. and Schulte, J. and Noguera, R. and Schleiermacher, G. and Janoueix-Lerosey, I. and Laureys, G. and Powel, R. and Nittner, D. and Marine, J-C and Ringnér, Markus and Speleman, F. and Vandesompele, J.},
  issn         = {1476-5594},
  keyword      = {non-coding RNA,neuroblastoma,T-UCR},
  language     = {eng},
  number       = {24},
  pages        = {3583--3592},
  publisher    = {Nature Publishing Group},
  series       = {Oncogene},
  title        = {An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours},
  url          = {http://dx.doi.org/10.1038/onc.2010.106},
  volume       = {29},
  year         = {2010},
}