Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study
(2010) In Blood 115(24). p.4991-4998- Abstract
- Patients with multiple myeloma (MM) have an increased risk of venous thrombosis. Interestingly, excess risk of venous thromboembolism has been observed among patients with monoclonal gammopathy of undetermined significance (MGUS). Using population-based data from Sweden, we assessed the risks of venous and arterial thrombosis in 18 627 MM and 5326 MGUS patients diagnosed from 1958 to 2006, compared with 70 991 and 20 161 matched controls, respectively. At 1, 5, and 10 years after MM diagnosis, there was an increased risk of venous thrombosis: hazard ratios (95% confidence intervals) were 7.5 (6.4-8.9), 4.6 (4.1-5.1), and 4.1 (3.8-4.5), respectively. The corresponding results for arterial thrombosis were 1.9 (1.8-2.1), 1.5 (1.4-1.6), and... (More)
- Patients with multiple myeloma (MM) have an increased risk of venous thrombosis. Interestingly, excess risk of venous thromboembolism has been observed among patients with monoclonal gammopathy of undetermined significance (MGUS). Using population-based data from Sweden, we assessed the risks of venous and arterial thrombosis in 18 627 MM and 5326 MGUS patients diagnosed from 1958 to 2006, compared with 70 991 and 20 161 matched controls, respectively. At 1, 5, and 10 years after MM diagnosis, there was an increased risk of venous thrombosis: hazard ratios (95% confidence intervals) were 7.5 (6.4-8.9), 4.6 (4.1-5.1), and 4.1 (3.8-4.5), respectively. The corresponding results for arterial thrombosis were 1.9 (1.8-2.1), 1.5 (1.4-1.6), and 1.5 (1.4-1.5). At 1, 5, and 10 years after MGUS diagnosis, hazard ratios were 3.4 (2.5-4.6), 2.1 (1.7-2.5), and 2.1 (1.8-2.4) for venous thrombosis. The corresponding risks for arterial thrombosis were 1.7 (1.5-1.9), 1.3 (1.2-1.4), and 1.3 (1.3-1.4). IgG/IgA (but not IgM) MGUS patients had increased risks for venous and arterial thrombosis. Risks for thrombosis did not vary by M-protein concentration (> 10.0 g/L or < 10.0 g/L) at diagnosis. MGUS patients with (vs without) thrombosis had no excess risk of MM or Waldenstrom macroglobulinemia. Our findings are of relevance for future studies and for improvement of thrombosis prophylaxis strategies. (Blood. 2010;115(24):4991-4998) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1630502
- author
- Kristinsson, Sigurdur Y. ; Pfeiffer, Ruth M. ; Bjorkholm, Magnus ; Goldin, Lynn R. ; Schulman, Sam ; Blimark, Cecilie ; Mellqvist, Ulf-Henrik ; Wahlin, Anders ; Turesson, Ingemar LU and Landgren, Ola
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 115
- issue
- 24
- pages
- 4991 - 4998
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000278888900006
- scopus:77954678537
- pmid:20299513
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2009-11-252072
- language
- English
- LU publication?
- yes
- id
- 220f58f8-906c-4f7f-aca2-f088abef8987 (old id 1630502)
- date added to LUP
- 2016-04-01 10:58:32
- date last changed
- 2022-04-28 03:25:23
@article{220f58f8-906c-4f7f-aca2-f088abef8987, abstract = {{Patients with multiple myeloma (MM) have an increased risk of venous thrombosis. Interestingly, excess risk of venous thromboembolism has been observed among patients with monoclonal gammopathy of undetermined significance (MGUS). Using population-based data from Sweden, we assessed the risks of venous and arterial thrombosis in 18 627 MM and 5326 MGUS patients diagnosed from 1958 to 2006, compared with 70 991 and 20 161 matched controls, respectively. At 1, 5, and 10 years after MM diagnosis, there was an increased risk of venous thrombosis: hazard ratios (95% confidence intervals) were 7.5 (6.4-8.9), 4.6 (4.1-5.1), and 4.1 (3.8-4.5), respectively. The corresponding results for arterial thrombosis were 1.9 (1.8-2.1), 1.5 (1.4-1.6), and 1.5 (1.4-1.5). At 1, 5, and 10 years after MGUS diagnosis, hazard ratios were 3.4 (2.5-4.6), 2.1 (1.7-2.5), and 2.1 (1.8-2.4) for venous thrombosis. The corresponding risks for arterial thrombosis were 1.7 (1.5-1.9), 1.3 (1.2-1.4), and 1.3 (1.3-1.4). IgG/IgA (but not IgM) MGUS patients had increased risks for venous and arterial thrombosis. Risks for thrombosis did not vary by M-protein concentration (> 10.0 g/L or < 10.0 g/L) at diagnosis. MGUS patients with (vs without) thrombosis had no excess risk of MM or Waldenstrom macroglobulinemia. Our findings are of relevance for future studies and for improvement of thrombosis prophylaxis strategies. (Blood. 2010;115(24):4991-4998)}}, author = {{Kristinsson, Sigurdur Y. and Pfeiffer, Ruth M. and Bjorkholm, Magnus and Goldin, Lynn R. and Schulman, Sam and Blimark, Cecilie and Mellqvist, Ulf-Henrik and Wahlin, Anders and Turesson, Ingemar and Landgren, Ola}}, issn = {{1528-0020}}, language = {{eng}}, number = {{24}}, pages = {{4991--4998}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study}}, url = {{http://dx.doi.org/10.1182/blood-2009-11-252072}}, doi = {{10.1182/blood-2009-11-252072}}, volume = {{115}}, year = {{2010}}, }