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The Swedish Reflux Trial in Children: I. Study Design and Study Population Characteristics

Brandstrom, Per; Esbjorner, Elisabeth; Herthelius, Maria; Holmdahl, Gundela; Lackgren, Goran; Neveus, Tryggve; Sillen, Ulla; Sixt, Rune; Sjöberg, Ingrid LU and Stokland, Eira, et al. (2010) International Conference on Vesicoureteral Reflux in Children In Journal of Urology 184(1). p.274-279
Abstract
Purpose: We compared the rates of febrile urinary tract infection, kidney damage and reflux resolution in children with vesicoureteral reflux treated in 3 ways, including antibiotic prophylaxis, endoscopic therapy and surveillance with antibiotics only for symptomatic urinary tract infection. Materials and Methods: Children 1 to younger than 2 years with grade reflux were recruited into this prospective, open, randomized, controlled, multi-center study and followed for 2 years after randomization. The main study end points were recurrent febrile urinary tract infection, renal status on dimercaptosuccinic acid scintigraphy and reflux status. Outcomes were analyzed by the intent to treat principle. Results: During a 6-year period 128 girls... (More)
Purpose: We compared the rates of febrile urinary tract infection, kidney damage and reflux resolution in children with vesicoureteral reflux treated in 3 ways, including antibiotic prophylaxis, endoscopic therapy and surveillance with antibiotics only for symptomatic urinary tract infection. Materials and Methods: Children 1 to younger than 2 years with grade reflux were recruited into this prospective, open, randomized, controlled, multi-center study and followed for 2 years after randomization. The main study end points were recurrent febrile urinary tract infection, renal status on dimercaptosuccinic acid scintigraphy and reflux status. Outcomes were analyzed by the intent to treat principle. Results: During a 6-year period 128 girls and 75 boys entered the study. In 96% of cases reflux was detected after urinary tract infection. The randomization procedure was successful and resulted in 3 groups matched for relevant factors. Recruitment was slower than anticipated but after patients were entered adherence to the protocol was good. Of the children 93% were followed for the intended 2 years without a treatment arm change. All except 2 patients completed 2-year followup scintigraphy. Conclusions: Recruitment was difficult but a substantial number of children were entered and randomly assigned to 3 groups with similar basic characteristics. Good adherence to the protocol made it possible to address the central study questions. (Less)
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
recurrence, disease, urinary tract infection, kidney, vesico-ureteral reflux, disease progression
in
Journal of Urology
volume
184
issue
1
pages
274 - 279
publisher
Elsevier
conference name
International Conference on Vesicoureteral Reflux in Children
external identifiers
  • wos:000278642300097
  • scopus:77953121656
ISSN
0022-5347
DOI
10.1016/j.juro.2010.01.055
language
English
LU publication?
yes
id
a31b69b1-b50f-43d4-b1d6-1757b98d2e49 (old id 1630939)
date added to LUP
2010-07-22 13:42:28
date last changed
2018-06-24 04:14:48
@inproceedings{a31b69b1-b50f-43d4-b1d6-1757b98d2e49,
  abstract     = {Purpose: We compared the rates of febrile urinary tract infection, kidney damage and reflux resolution in children with vesicoureteral reflux treated in 3 ways, including antibiotic prophylaxis, endoscopic therapy and surveillance with antibiotics only for symptomatic urinary tract infection. Materials and Methods: Children 1 to younger than 2 years with grade reflux were recruited into this prospective, open, randomized, controlled, multi-center study and followed for 2 years after randomization. The main study end points were recurrent febrile urinary tract infection, renal status on dimercaptosuccinic acid scintigraphy and reflux status. Outcomes were analyzed by the intent to treat principle. Results: During a 6-year period 128 girls and 75 boys entered the study. In 96% of cases reflux was detected after urinary tract infection. The randomization procedure was successful and resulted in 3 groups matched for relevant factors. Recruitment was slower than anticipated but after patients were entered adherence to the protocol was good. Of the children 93% were followed for the intended 2 years without a treatment arm change. All except 2 patients completed 2-year followup scintigraphy. Conclusions: Recruitment was difficult but a substantial number of children were entered and randomly assigned to 3 groups with similar basic characteristics. Good adherence to the protocol made it possible to address the central study questions.},
  author       = {Brandstrom, Per and Esbjorner, Elisabeth and Herthelius, Maria and Holmdahl, Gundela and Lackgren, Goran and Neveus, Tryggve and Sillen, Ulla and Sixt, Rune and Sjöberg, Ingrid and Stokland, Eira and Jodal, Ulf and Hansson, Sverker},
  booktitle    = {Journal of Urology},
  issn         = {0022-5347},
  keyword      = {recurrence,disease,urinary tract infection,kidney,vesico-ureteral reflux,disease progression},
  language     = {eng},
  number       = {1},
  pages        = {274--279},
  publisher    = {Elsevier},
  title        = {The Swedish Reflux Trial in Children: I. Study Design and Study Population Characteristics},
  url          = {http://dx.doi.org/10.1016/j.juro.2010.01.055},
  volume       = {184},
  year         = {2010},
}