Simultaneous quantification of myocardial perfusion, oxidative metabolism, cardiac efficiency and pump function at rest and during supine bicycle exercise using 1-11C-acetate PET - a pilot study
(2010) In Clinical Physiology and Functional Imaging 30(4). p.279-284- Abstract
- P>Background: PET using 1-11C-acetate (ACE-PET) applied at rest is used for measuring absolute myocardial blood flow (MBF) and oxidative metabolic rate (k(mono)). We evaluated the feasibility of quantitative ACE-PET during exercise. Methods: Five endurance athletes underwent dynamic PET scanning at rest and during supine bicycle stress. Exercise was maintained at a workload of 120 Watt for 17 min. The rate-pressure product (RPP) was recorded repeatedly. MBF, k(mono) in left (LV) and right (RV) ventricular wall, cardiac output (CO), cardiac efficiency and a lung uptake value reflecting left heart diastolic pressures were calculated from the PET data using previously validated models. Results: MBF increased from 0 center dot 71 +/- 0... (More)
- P>Background: PET using 1-11C-acetate (ACE-PET) applied at rest is used for measuring absolute myocardial blood flow (MBF) and oxidative metabolic rate (k(mono)). We evaluated the feasibility of quantitative ACE-PET during exercise. Methods: Five endurance athletes underwent dynamic PET scanning at rest and during supine bicycle stress. Exercise was maintained at a workload of 120 Watt for 17 min. The rate-pressure product (RPP) was recorded repeatedly. MBF, k(mono) in left (LV) and right (RV) ventricular wall, cardiac output (CO), cardiac efficiency and a lung uptake value reflecting left heart diastolic pressures were calculated from the PET data using previously validated models. Results: MBF increased from 0 center dot 71 +/- 0 center dot 17 to 2 center dot 48 +/- 0 center dot 25 ml min-1 per ml, LV-k(mono) from 0 center dot 050 +/- 0 center dot 005 to 0 center dot 146 +/- 0 center dot 021 min-1, RV-k(mono) from 0 center dot 023 + 0 center dot 006 to 0 center dot 087 + 0 center dot 014 min-1, RPP from 4 center dot 7 +/- 0 center dot 8 to 13 center dot 2 +/- 1 center dot 4 mmHg x min-1 x 103 and Cardiac Output from 5 center dot 2 +/- 1 center dot 1 to 12 center dot 3 +/- 1 center dot 2 l min -1 (all P < 0 center dot 001). Cardiac efficiency was unchanged (P = 0 center dot 99). Lung uptake decreased from 1 center dot 1 +/- 0 center dot 2 to 0 center dot 6 +/- 0 center dot 1 ml g-1 (P < 0 center dot 001). Discussion: A number of important parameters related to cardiac function can be quantified non-invasively and simultaneously with a short scanning protocol during steady state supine bicycling. This might open up new opportunities for studies of the integrated cardiac physiology in health and early asymptomatic disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1631456
- author
- Sorensen, Jens ; Valind, Sven LU and Andersson, Lars G.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- metabolism, oxidative, myocardial blood flow, cardiac physiology, exercise testing, positron emission tomography
- in
- Clinical Physiology and Functional Imaging
- volume
- 30
- issue
- 4
- pages
- 279 - 284
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000278564500008
- scopus:77954134168
- ISSN
- 1475-0961
- DOI
- 10.1111/j.1475-097X.2010.00938.x
- language
- English
- LU publication?
- yes
- id
- ec8a76bd-3194-4d50-871b-953ae596e5b6 (old id 1631456)
- date added to LUP
- 2016-04-01 11:04:06
- date last changed
- 2023-08-31 17:52:17
@article{ec8a76bd-3194-4d50-871b-953ae596e5b6,
abstract = {{P>Background: PET using 1-11C-acetate (ACE-PET) applied at rest is used for measuring absolute myocardial blood flow (MBF) and oxidative metabolic rate (k(mono)). We evaluated the feasibility of quantitative ACE-PET during exercise. Methods: Five endurance athletes underwent dynamic PET scanning at rest and during supine bicycle stress. Exercise was maintained at a workload of 120 Watt for 17 min. The rate-pressure product (RPP) was recorded repeatedly. MBF, k(mono) in left (LV) and right (RV) ventricular wall, cardiac output (CO), cardiac efficiency and a lung uptake value reflecting left heart diastolic pressures were calculated from the PET data using previously validated models. Results: MBF increased from 0 center dot 71 +/- 0 center dot 17 to 2 center dot 48 +/- 0 center dot 25 ml min-1 per ml, LV-k(mono) from 0 center dot 050 +/- 0 center dot 005 to 0 center dot 146 +/- 0 center dot 021 min-1, RV-k(mono) from 0 center dot 023 + 0 center dot 006 to 0 center dot 087 + 0 center dot 014 min-1, RPP from 4 center dot 7 +/- 0 center dot 8 to 13 center dot 2 +/- 1 center dot 4 mmHg x min-1 x 103 and Cardiac Output from 5 center dot 2 +/- 1 center dot 1 to 12 center dot 3 +/- 1 center dot 2 l min -1 (all P < 0 center dot 001). Cardiac efficiency was unchanged (P = 0 center dot 99). Lung uptake decreased from 1 center dot 1 +/- 0 center dot 2 to 0 center dot 6 +/- 0 center dot 1 ml g-1 (P < 0 center dot 001). Discussion: A number of important parameters related to cardiac function can be quantified non-invasively and simultaneously with a short scanning protocol during steady state supine bicycling. This might open up new opportunities for studies of the integrated cardiac physiology in health and early asymptomatic disease.}},
author = {{Sorensen, Jens and Valind, Sven and Andersson, Lars G.}},
issn = {{1475-0961}},
keywords = {{metabolism; oxidative; myocardial blood flow; cardiac physiology; exercise testing; positron emission tomography}},
language = {{eng}},
number = {{4}},
pages = {{279--284}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Clinical Physiology and Functional Imaging}},
title = {{Simultaneous quantification of myocardial perfusion, oxidative metabolism, cardiac efficiency and pump function at rest and during supine bicycle exercise using 1-11C-acetate PET - a pilot study}},
url = {{http://dx.doi.org/10.1111/j.1475-097X.2010.00938.x}},
doi = {{10.1111/j.1475-097X.2010.00938.x}},
volume = {{30}},
year = {{2010}},
}