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Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by directional fractal signature method

Wolski, M.; Podsiadlo, P.; Stachowiak, G. W.; Lohmander, Stefan LU and Englund, Martin LU (2010) In Osteoarthritis and Cartilage 18(5). p.684-690
Abstract
Objective: To evaluate differences in tibial trabecular bone (TB) texture between subjects with and without radiographic knee osteoarthritis (OA) using a variance orientation transform (VOT) method. Design: Subjects with knee OA (Kellgren & Lawrence grade >= 2) and controls without OA (both n = 26, seven women) were matched by sex, age, body mass index and compartment. The VOT method was applied to TB X-ray images and fractal signature and dimension in horizontal (FSH, FDH) and vertical (FSV, FDV) directions and along the roughest part of TB (FSSta, FDSta), texture aspect ratio (Str) and signature (StrS), and mean FD (FDMEAN) were calculated. The VOT method was compared against an augmented Hurst orientation transform (HOT) method... (More)
Objective: To evaluate differences in tibial trabecular bone (TB) texture between subjects with and without radiographic knee osteoarthritis (OA) using a variance orientation transform (VOT) method. Design: Subjects with knee OA (Kellgren & Lawrence grade >= 2) and controls without OA (both n = 26, seven women) were matched by sex, age, body mass index and compartment. The VOT method was applied to TB X-ray images and fractal signature and dimension in horizontal (FSH, FDH) and vertical (FSV, FDV) directions and along the roughest part of TB (FSSta, FDSta), texture aspect ratio (Str) and signature (StrS), and mean FD (FDMEAN) were calculated. The VOT method was compared against an augmented Hurst orientation transform (HOT) method using paired t tests, intraclass correlation coefficients (ICCs) and coefficients of variation (CVs%). Longitudinal sensitivity to OA bone changes was not assessed. Results: For the reproducibility of texture parameters, ICCs were >0.75 and CVs% were <8.2% for both methods. Compared with controls, FDMEAN, FDH, FDV and FDSta for OA knees were lower (P < 0.001), while Str was higher in both medial (P = 0.03) and lateral (P = 0.02) compartments. FSH, FSSta were lower for OA knees than for controls at sizes 0.3-0.7 mm (P < 0.001) in both compartments. In lateral compartment, FSV for OA knees was lower than for controls at sizes 0.3-0.5 mm (P < 0.001) and 0.55-0.70 mm (P < 0.02), while in medial compartment at sizes 0.3-0.7 mm (P < 0.001). Compared with controls, StrS for OA knees was higher at sizes 0.3, 0.55-0.70 mm in medial (P < 0.03) and lateral (P < 0.04) compartments. Conclusions: The VOT method is comparable to HOT method in the reproducibility of texture parameters and the ability to discriminate between non-OA and OA TB textures. However, unlike the HOT method, it quantifies texture roughness along the roughest part of the tibial bone, texture anisotropy at individual trabecular sizes and it works over a larger range of trabecular sizes. The VOT method may be a valuable tool for studying OA changes in TB. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Osteoarthritis, Fractal analysis, Plain radiography, Trabecular bone
in
Osteoarthritis and Cartilage
volume
18
issue
5
pages
684 - 690
publisher
Elsevier
external identifiers
  • wos:000278175600013
  • scopus:77952551157
ISSN
1063-4584
DOI
10.1016/j.joca.2010.01.002
language
English
LU publication?
yes
id
c4b09678-4ed1-4b5d-ba3c-a1e36fb08b77 (old id 1631718)
date added to LUP
2010-07-21 10:47:54
date last changed
2018-05-29 11:53:12
@article{c4b09678-4ed1-4b5d-ba3c-a1e36fb08b77,
  abstract     = {Objective: To evaluate differences in tibial trabecular bone (TB) texture between subjects with and without radiographic knee osteoarthritis (OA) using a variance orientation transform (VOT) method. Design: Subjects with knee OA (Kellgren &amp; Lawrence grade &gt;= 2) and controls without OA (both n = 26, seven women) were matched by sex, age, body mass index and compartment. The VOT method was applied to TB X-ray images and fractal signature and dimension in horizontal (FSH, FDH) and vertical (FSV, FDV) directions and along the roughest part of TB (FSSta, FDSta), texture aspect ratio (Str) and signature (StrS), and mean FD (FDMEAN) were calculated. The VOT method was compared against an augmented Hurst orientation transform (HOT) method using paired t tests, intraclass correlation coefficients (ICCs) and coefficients of variation (CVs%). Longitudinal sensitivity to OA bone changes was not assessed. Results: For the reproducibility of texture parameters, ICCs were &gt;0.75 and CVs% were &lt;8.2% for both methods. Compared with controls, FDMEAN, FDH, FDV and FDSta for OA knees were lower (P &lt; 0.001), while Str was higher in both medial (P = 0.03) and lateral (P = 0.02) compartments. FSH, FSSta were lower for OA knees than for controls at sizes 0.3-0.7 mm (P &lt; 0.001) in both compartments. In lateral compartment, FSV for OA knees was lower than for controls at sizes 0.3-0.5 mm (P &lt; 0.001) and 0.55-0.70 mm (P &lt; 0.02), while in medial compartment at sizes 0.3-0.7 mm (P &lt; 0.001). Compared with controls, StrS for OA knees was higher at sizes 0.3, 0.55-0.70 mm in medial (P &lt; 0.03) and lateral (P &lt; 0.04) compartments. Conclusions: The VOT method is comparable to HOT method in the reproducibility of texture parameters and the ability to discriminate between non-OA and OA TB textures. However, unlike the HOT method, it quantifies texture roughness along the roughest part of the tibial bone, texture anisotropy at individual trabecular sizes and it works over a larger range of trabecular sizes. The VOT method may be a valuable tool for studying OA changes in TB. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.},
  author       = {Wolski, M. and Podsiadlo, P. and Stachowiak, G. W. and Lohmander, Stefan and Englund, Martin},
  issn         = {1063-4584},
  keyword      = {Osteoarthritis,Fractal analysis,Plain radiography,Trabecular bone},
  language     = {eng},
  number       = {5},
  pages        = {684--690},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by directional fractal signature method},
  url          = {http://dx.doi.org/10.1016/j.joca.2010.01.002},
  volume       = {18},
  year         = {2010},
}