Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry.
(2006) In Blood Coagulation and Fibrinolysis 17(8). p.661-665- Abstract
- The objective was to study the effects of ethanol on coagulation and fibrinolysis in whole blood. Blood samples from healthy volunteers were analyzed before and after in-vitro addition of ethanol in order to achieve ethanol concentrations of 0, 1, 2 and 4[per mille sign], respectively (0, 22, 44 and 88 mmol/l). Coagulation and fibrinolysis were then assessed using rotational thromboelastometry. We found that increasing ethanol levels increasingly impaired coagulation as evaluated with rotational thromboelastometry, with a maximum prolongation of the clot formation time of 118% at an ethanol level of 4[per mille sign] (P < 0.000001). We also found a very strong impairment of fibrinolysis already at an ethanol level of 1[per mille sign].... (More)
- The objective was to study the effects of ethanol on coagulation and fibrinolysis in whole blood. Blood samples from healthy volunteers were analyzed before and after in-vitro addition of ethanol in order to achieve ethanol concentrations of 0, 1, 2 and 4[per mille sign], respectively (0, 22, 44 and 88 mmol/l). Coagulation and fibrinolysis were then assessed using rotational thromboelastometry. We found that increasing ethanol levels increasingly impaired coagulation as evaluated with rotational thromboelastometry, with a maximum prolongation of the clot formation time of 118% at an ethanol level of 4[per mille sign] (P < 0.000001). We also found a very strong impairment of fibrinolysis already at an ethanol level of 1[per mille sign]. This is the first study assessing the effects of ethanol on coagulation and fibrinolysis in a whole blood model. The impairment of coagulation is similar in nature to the impairment found in patients suffering from hypothermia. The impairment is at a level that may be of clinical importance (e.g. in patients suffering from trauma). The inhibition of fibrinolysis is obvious already at an ethanol level of 1[per mille sign] and it may be a contributing factor to the increased amount of coronary and cerebrovascular ischemic events after binge drinking. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/163248
- author
- Engström, Martin LU ; Schött, Ulf LU and Reinstrup, Peter LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- fibrinolysis, alcohol, ethanol, thromboelastometry, rotational, coagulation
- in
- Blood Coagulation and Fibrinolysis
- volume
- 17
- issue
- 8
- pages
- 661 - 665
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000242672700009
- scopus:33751031875
- pmid:17102653
- ISSN
- 1473-5733
- DOI
- 10.1097/MBC.0b013e32801010b7
- project
- Koagulation vid kirurgi och kritisk sjukdom
- language
- English
- LU publication?
- yes
- id
- b603c75b-8a2b-4d43-ac02-b079e63fd496 (old id 163248)
- date added to LUP
- 2016-04-01 12:15:08
- date last changed
- 2022-01-27 01:00:57
@article{b603c75b-8a2b-4d43-ac02-b079e63fd496, abstract = {{The objective was to study the effects of ethanol on coagulation and fibrinolysis in whole blood. Blood samples from healthy volunteers were analyzed before and after in-vitro addition of ethanol in order to achieve ethanol concentrations of 0, 1, 2 and 4[per mille sign], respectively (0, 22, 44 and 88 mmol/l). Coagulation and fibrinolysis were then assessed using rotational thromboelastometry. We found that increasing ethanol levels increasingly impaired coagulation as evaluated with rotational thromboelastometry, with a maximum prolongation of the clot formation time of 118% at an ethanol level of 4[per mille sign] (P < 0.000001). We also found a very strong impairment of fibrinolysis already at an ethanol level of 1[per mille sign]. This is the first study assessing the effects of ethanol on coagulation and fibrinolysis in a whole blood model. The impairment of coagulation is similar in nature to the impairment found in patients suffering from hypothermia. The impairment is at a level that may be of clinical importance (e.g. in patients suffering from trauma). The inhibition of fibrinolysis is obvious already at an ethanol level of 1[per mille sign] and it may be a contributing factor to the increased amount of coronary and cerebrovascular ischemic events after binge drinking.}}, author = {{Engström, Martin and Schött, Ulf and Reinstrup, Peter}}, issn = {{1473-5733}}, keywords = {{fibrinolysis; alcohol; ethanol; thromboelastometry; rotational; coagulation}}, language = {{eng}}, number = {{8}}, pages = {{661--665}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Blood Coagulation and Fibrinolysis}}, title = {{Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry.}}, url = {{https://lup.lub.lu.se/search/files/2846074/625757.pdf}}, doi = {{10.1097/MBC.0b013e32801010b7}}, volume = {{17}}, year = {{2006}}, }