The contact system-a novel branch of innate immunity generating antibacterial peptides.
(2006) In EMBO Journal 25(23). p.5569-5578- Abstract
- Activation of the contact system has two classical consequences: initiation of the intrinsic pathway of coagulation, and cleavage of high molecular weight kininogen (HK) leading to the release of bradykinin, a potent proinflammatory peptide. In human plasma, activation of the contact system at the surface of significant bacterial pathogens was found to result in further HK processing and bacterial killing. A fragment comprising the D3 domain of HK is generated, and within this fragment a sequence of 26 amino acids is mainly responsible for the antibacterial activity. A synthetic peptide covering this sequence kills several bacterial species, also at physiological salt concentration, as effectively as the classical human antibacterial... (More)
- Activation of the contact system has two classical consequences: initiation of the intrinsic pathway of coagulation, and cleavage of high molecular weight kininogen (HK) leading to the release of bradykinin, a potent proinflammatory peptide. In human plasma, activation of the contact system at the surface of significant bacterial pathogens was found to result in further HK processing and bacterial killing. A fragment comprising the D3 domain of HK is generated, and within this fragment a sequence of 26 amino acids is mainly responsible for the antibacterial activity. A synthetic peptide covering this sequence kills several bacterial species, also at physiological salt concentration, as effectively as the classical human antibacterial peptide LL-37. Moreover, in an animal model of infection, inhibition of the contact system promotes bacterial dissemination and growth. These data identify a novel and important role for the contact system in the defence against invasive bacterial infection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/163334
- author
- Frick, Inga-Maria
LU
; Åkesson, Per
LU
; Herwald, Heiko
LU
; Mörgelin, Matthias LU ; Malmsten, Martin LU ; Nagler, Dorit K and Björck, Lars LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bacterial killing, antibacterial peptides, contact system, innate, immunity
- in
- EMBO Journal
- volume
- 25
- issue
- 23
- pages
- 5569 - 5578
- publisher
- Oxford University Press
- external identifiers
-
- wos:000242890900012
- scopus:33751579326
- ISSN
- 1460-2075
- DOI
- 10.1038/sj.emboj.7601422
- language
- English
- LU publication?
- yes
- id
- 0405b2d5-8f97-4b79-ab7e-3650af7cc666 (old id 163334)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17093496&dopt=Abstract
- date added to LUP
- 2016-04-01 16:41:22
- date last changed
- 2022-01-28 21:23:15
@article{0405b2d5-8f97-4b79-ab7e-3650af7cc666, abstract = {{Activation of the contact system has two classical consequences: initiation of the intrinsic pathway of coagulation, and cleavage of high molecular weight kininogen (HK) leading to the release of bradykinin, a potent proinflammatory peptide. In human plasma, activation of the contact system at the surface of significant bacterial pathogens was found to result in further HK processing and bacterial killing. A fragment comprising the D3 domain of HK is generated, and within this fragment a sequence of 26 amino acids is mainly responsible for the antibacterial activity. A synthetic peptide covering this sequence kills several bacterial species, also at physiological salt concentration, as effectively as the classical human antibacterial peptide LL-37. Moreover, in an animal model of infection, inhibition of the contact system promotes bacterial dissemination and growth. These data identify a novel and important role for the contact system in the defence against invasive bacterial infection.}}, author = {{Frick, Inga-Maria and Åkesson, Per and Herwald, Heiko and Mörgelin, Matthias and Malmsten, Martin and Nagler, Dorit K and Björck, Lars}}, issn = {{1460-2075}}, keywords = {{bacterial killing; antibacterial peptides; contact system; innate; immunity}}, language = {{eng}}, number = {{23}}, pages = {{5569--5578}}, publisher = {{Oxford University Press}}, series = {{EMBO Journal}}, title = {{The contact system-a novel branch of innate immunity generating antibacterial peptides.}}, url = {{http://dx.doi.org/10.1038/sj.emboj.7601422}}, doi = {{10.1038/sj.emboj.7601422}}, volume = {{25}}, year = {{2006}}, }