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Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy.

Ryding, Erik LU ; Ahnlide, Jan Anders LU ; Lindström, Mats LU ; Rosén, Ingmar LU and Träskman Bendz, Lil LU (2006) In Psychiatry Research 148(2-3). p.195-203
Abstract
To study different aspects of regional pre-synaptic brain 123I-β-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-uptake (5HTT) and dopamine re-uptake (DAT) capacity (binding potential, BPlow asterisk) after i.v. 123I-β-CIT administration. All suicide attempters were examined concerning seriousness of the attempt, and DSM-IV diagnosis. Both suicide attempters and control subjects were tested for psychotropic drugs, and completed the Marke-Nyman Temperament (MNT) test, including solidity (level of impulsiveness/initiative) and validity (level of... (More)
To study different aspects of regional pre-synaptic brain 123I-β-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-uptake (5HTT) and dopamine re-uptake (DAT) capacity (binding potential, BPlow asterisk) after i.v. 123I-β-CIT administration. All suicide attempters were examined concerning seriousness of the attempt, and DSM-IV diagnosis. Both suicide attempters and control subjects were tested for psychotropic drugs, and completed the Marke-Nyman Temperament (MNT) test, including solidity (level of impulsiveness/initiative) and validity (level of mental energy). We found no significant difference between suicide attempters and control subjects concerning the regional levels of 5HTT BPlow asterisk or DAT BPlow asterisk. However, in suicide attempters, but not controls, we found significant regional correlations between MNT variables and SPECT results. We interpret the discrepant findings in suicide attempters and control subjects to be due to a disability of the suicide attempters to regulate their serotonin and dopamine levels, e.g. in response to external stress. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
<sup>123</sup>I-β-CIT, SPECT, Depression, Marke-Nyman Temperament test
in
Psychiatry Research
volume
148
issue
2-3
pages
195 - 203
publisher
Elsevier
external identifiers
  • wos:000242885800012
  • scopus:33751014851
  • pmid:17085020
ISSN
1872-7123
DOI
10.1016/j.pscychresns.2006.06.001
language
English
LU publication?
yes
id
123d5afb-8c2b-4bf2-9083-c5b3a0a125dd (old id 163414)
date added to LUP
2016-04-01 12:33:48
date last changed
2021-02-17 03:12:40
@article{123d5afb-8c2b-4bf2-9083-c5b3a0a125dd,
  abstract     = {To study different aspects of regional pre-synaptic brain 123I-β-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-uptake (5HTT) and dopamine re-uptake (DAT) capacity (binding potential, BPlow asterisk) after i.v. 123I-β-CIT administration. All suicide attempters were examined concerning seriousness of the attempt, and DSM-IV diagnosis. Both suicide attempters and control subjects were tested for psychotropic drugs, and completed the Marke-Nyman Temperament (MNT) test, including solidity (level of impulsiveness/initiative) and validity (level of mental energy). We found no significant difference between suicide attempters and control subjects concerning the regional levels of 5HTT BPlow asterisk or DAT BPlow asterisk. However, in suicide attempters, but not controls, we found significant regional correlations between MNT variables and SPECT results. We interpret the discrepant findings in suicide attempters and control subjects to be due to a disability of the suicide attempters to regulate their serotonin and dopamine levels, e.g. in response to external stress.},
  author       = {Ryding, Erik and Ahnlide, Jan Anders and Lindström, Mats and Rosén, Ingmar and Träskman Bendz, Lil},
  issn         = {1872-7123},
  language     = {eng},
  number       = {2-3},
  pages        = {195--203},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy.},
  url          = {http://dx.doi.org/10.1016/j.pscychresns.2006.06.001},
  doi          = {10.1016/j.pscychresns.2006.06.001},
  volume       = {148},
  year         = {2006},
}