Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy.
Ryding, Erik LU ; Ahnlide, Jan Anders LU ; Lindström, Mats LU
; Rosén, Ingmar
LU
and Träskman Bendz, Lil
LU
(2006)
In Psychiatry Research
148(2-3).
p.195-203
- Abstract
- To study different aspects of regional pre-synaptic brain 123I-β-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-uptake (5HTT) and dopamine re-uptake (DAT) capacity (binding potential, BPlow asterisk) after i.v. 123I-β-CIT administration. All suicide attempters were examined concerning seriousness of the attempt, and DSM-IV diagnosis. Both suicide attempters and control subjects were tested for psychotropic drugs, and completed the Marke-Nyman Temperament (MNT) test, including solidity (level of impulsiveness/initiative) and validity (level of... (More)
- To study different aspects of regional pre-synaptic brain 123I-β-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-uptake (5HTT) and dopamine re-uptake (DAT) capacity (binding potential, BPlow asterisk) after i.v. 123I-β-CIT administration. All suicide attempters were examined concerning seriousness of the attempt, and DSM-IV diagnosis. Both suicide attempters and control subjects were tested for psychotropic drugs, and completed the Marke-Nyman Temperament (MNT) test, including solidity (level of impulsiveness/initiative) and validity (level of mental energy). We found no significant difference between suicide attempters and control subjects concerning the regional levels of 5HTT BPlow asterisk or DAT BPlow asterisk. However, in suicide attempters, but not controls, we found significant regional correlations between MNT variables and SPECT results. We interpret the discrepant findings in suicide attempters and control subjects to be due to a disability of the suicide attempters to regulate their serotonin and dopamine levels, e.g. in response to external stress. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/163414
- author
- Ryding, Erik
LU
; Ahnlide, Jan Anders
LU
; Lindström, Mats
LU
; Rosén, Ingmar
LU
and Träskman Bendz, Lil
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- <sup>123</sup>I-β-CIT, SPECT, Depression, Marke-Nyman Temperament test
- in
- Psychiatry Research
- volume
- 148
- issue
- 2-3
- pages
- 195 - 203
- publisher
- Elsevier
- external identifiers
-
- wos:000242885800012
- scopus:33751014851
- pmid:17085020
- ISSN
- 1872-7123
- DOI
- 10.1016/j.pscychresns.2006.06.001
- language
- English
- LU publication?
- yes
- id
- 123d5afb-8c2b-4bf2-9083-c5b3a0a125dd (old id 163414)
- date added to LUP
- 2016-04-01 12:33:48
- date last changed
- 2022-03-06 01:16:42
@article{123d5afb-8c2b-4bf2-9083-c5b3a0a125dd,
abstract = {{To study different aspects of regional pre-synaptic brain 123I-β-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-uptake (5HTT) and dopamine re-uptake (DAT) capacity (binding potential, BPlow asterisk) after i.v. 123I-β-CIT administration. All suicide attempters were examined concerning seriousness of the attempt, and DSM-IV diagnosis. Both suicide attempters and control subjects were tested for psychotropic drugs, and completed the Marke-Nyman Temperament (MNT) test, including solidity (level of impulsiveness/initiative) and validity (level of mental energy). We found no significant difference between suicide attempters and control subjects concerning the regional levels of 5HTT BPlow asterisk or DAT BPlow asterisk. However, in suicide attempters, but not controls, we found significant regional correlations between MNT variables and SPECT results. We interpret the discrepant findings in suicide attempters and control subjects to be due to a disability of the suicide attempters to regulate their serotonin and dopamine levels, e.g. in response to external stress.}},
author = {{Ryding, Erik and Ahnlide, Jan Anders and Lindström, Mats and Rosén, Ingmar and Träskman Bendz, Lil}},
issn = {{1872-7123}},
keywords = {{<sup>123</sup>I-β-CIT; SPECT; Depression; Marke-Nyman Temperament test}},
language = {{eng}},
number = {{2-3}},
pages = {{195--203}},
publisher = {{Elsevier}},
series = {{Psychiatry Research}},
title = {{Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy.}},
url = {{http://dx.doi.org/10.1016/j.pscychresns.2006.06.001}},
doi = {{10.1016/j.pscychresns.2006.06.001}},
volume = {{148}},
year = {{2006}},
}