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Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6/1 and R6/2 mouse models of Huntington's disease.

Van der Borght, Karin LU and Brundin, Patrik LU (2007) In Experimental Neurology 204(1). p.473-478
Abstract
Cognitive deficits and impaired olfactory function are observed in early stages of Huntington's disease (HD). The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is strongly associated with plastic events in the brain. During adulthood, it is most abundantly expressed in the hippocampus and the piriform cortex, which are involved in cognition and olfaction, respectively. We show that the numbers of PSA-NCAM-positive cells in the hippocampus and piriform cortex are dramatically reduced in the R6/1 and the R6/2 mouse models of HD. We hypothesize that the decrease in NCAM polysialylation reflects an impaired plasticity and might underlie some of the early symptoms in HD.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Neurology
volume
204
issue
1
pages
473 - 478
publisher
Academic Press
external identifiers
  • wos:000245086100049
  • scopus:33847270651
ISSN
0014-4886
DOI
10.1016/j.expneurol.2006.10.014
language
English
LU publication?
yes
id
82180fe1-cc67-4585-9add-41a901d2ac84 (old id 163778)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17187781&query_hl=3&itool=pubmed_docsum
date added to LUP
2007-07-20 11:09:40
date last changed
2017-11-05 03:37:20
@article{82180fe1-cc67-4585-9add-41a901d2ac84,
  abstract     = {Cognitive deficits and impaired olfactory function are observed in early stages of Huntington's disease (HD). The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is strongly associated with plastic events in the brain. During adulthood, it is most abundantly expressed in the hippocampus and the piriform cortex, which are involved in cognition and olfaction, respectively. We show that the numbers of PSA-NCAM-positive cells in the hippocampus and piriform cortex are dramatically reduced in the R6/1 and the R6/2 mouse models of HD. We hypothesize that the decrease in NCAM polysialylation reflects an impaired plasticity and might underlie some of the early symptoms in HD.},
  author       = {Van der Borght, Karin and Brundin, Patrik},
  issn         = {0014-4886},
  language     = {eng},
  number       = {1},
  pages        = {473--478},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6/1 and R6/2 mouse models of Huntington's disease.},
  url          = {http://dx.doi.org/10.1016/j.expneurol.2006.10.014},
  volume       = {204},
  year         = {2007},
}