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Long-term change in cholesterol in relation to inflammation-sensitive plasma proteins: a longitudinal study.

Engström, Gunnar LU ; Hedblad, Bo LU ; Janzon, Lars LU and Lindgärde, Folke LU (2007) In Annals of Epidemiology 17(1). p.57-63
Abstract
PURPOSE: The nature of the relationship between inflammation and elevated serum lipid levels is incompletely understood. This longitudinal study explores whether elevated levels of inflammation-sensitive plasma proteins (ISPs) are a risk factor for developing increased cholesterol and triglyceride levels. METHODS: Five ISPs (fibrinogen, orosomucoid, alpha(1)-antitrypsin, haptoglobin, and ceruloplasmin) were measured in a population-based cohort of nondiabetic healthy men aged 38 to 50 years at baseline. Subjects were reexamined after a mean of 6.2 years. The development of hypercholesterolemia (cholesterol >= 6.5 mmol/L [>= 251 mg/dL]) and hypertriglyceridemia (triglycerides >= 2.3 mmol/L [>= 204 mg/dL]) during follow-up was... (More)
PURPOSE: The nature of the relationship between inflammation and elevated serum lipid levels is incompletely understood. This longitudinal study explores whether elevated levels of inflammation-sensitive plasma proteins (ISPs) are a risk factor for developing increased cholesterol and triglyceride levels. METHODS: Five ISPs (fibrinogen, orosomucoid, alpha(1)-antitrypsin, haptoglobin, and ceruloplasmin) were measured in a population-based cohort of nondiabetic healthy men aged 38 to 50 years at baseline. Subjects were reexamined after a mean of 6.2 years. The development of hypercholesterolemia (cholesterol >= 6.5 mmol/L [>= 251 mg/dL]) and hypertriglyceridemia (triglycerides >= 2.3 mmol/L [>= 204 mg/dL]) during follow-up was studied in relation to the number of elevated levels of ISPs (i.e., in the top quartile). RESULTS: Of men with initially normal cholesterol levels (< 6.5 mmol/L; n = 2224), proportions of men with no, one, two, and three or more elevated ISP levels at baseline who developed hypercholesterolemia were 12%, 13%, 16%, and 20%, respectively (p for trend = 0.0002). This relationship remained significant after adjustments for cholesterol level at baseline and other confounding factors. The relationship between ISP levels and future hypertriglyceridemia was attenuated and nonsignificant after adjustments for confounding factors. CONCLUSION: In apparently healthy men with initially normal cholesterol levels, elevated ISP levels are a risk factor for development of hypercholesterolemia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Epidemiology
volume
17
issue
1
pages
57 - 63
publisher
Elsevier
external identifiers
  • wos:000243281300008
  • scopus:33845402342
ISSN
1047-2797
DOI
10.1016/j.annepidem.2006.03.005
language
English
LU publication?
yes
id
7a36e3f2-b37d-4b0d-8e55-d9be5b0768f2 (old id 163896)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17178329&dopt=Abstract
date added to LUP
2007-07-18 14:20:11
date last changed
2017-08-20 03:35:32
@article{7a36e3f2-b37d-4b0d-8e55-d9be5b0768f2,
  abstract     = {PURPOSE: The nature of the relationship between inflammation and elevated serum lipid levels is incompletely understood. This longitudinal study explores whether elevated levels of inflammation-sensitive plasma proteins (ISPs) are a risk factor for developing increased cholesterol and triglyceride levels. METHODS: Five ISPs (fibrinogen, orosomucoid, alpha(1)-antitrypsin, haptoglobin, and ceruloplasmin) were measured in a population-based cohort of nondiabetic healthy men aged 38 to 50 years at baseline. Subjects were reexamined after a mean of 6.2 years. The development of hypercholesterolemia (cholesterol &gt;= 6.5 mmol/L [&gt;= 251 mg/dL]) and hypertriglyceridemia (triglycerides &gt;= 2.3 mmol/L [&gt;= 204 mg/dL]) during follow-up was studied in relation to the number of elevated levels of ISPs (i.e., in the top quartile). RESULTS: Of men with initially normal cholesterol levels (&lt; 6.5 mmol/L; n = 2224), proportions of men with no, one, two, and three or more elevated ISP levels at baseline who developed hypercholesterolemia were 12%, 13%, 16%, and 20%, respectively (p for trend = 0.0002). This relationship remained significant after adjustments for cholesterol level at baseline and other confounding factors. The relationship between ISP levels and future hypertriglyceridemia was attenuated and nonsignificant after adjustments for confounding factors. CONCLUSION: In apparently healthy men with initially normal cholesterol levels, elevated ISP levels are a risk factor for development of hypercholesterolemia.},
  author       = {Engström, Gunnar and Hedblad, Bo and Janzon, Lars and Lindgärde, Folke},
  issn         = {1047-2797},
  language     = {eng},
  number       = {1},
  pages        = {57--63},
  publisher    = {Elsevier},
  series       = {Annals of Epidemiology},
  title        = {Long-term change in cholesterol in relation to inflammation-sensitive plasma proteins: a longitudinal study.},
  url          = {http://dx.doi.org/10.1016/j.annepidem.2006.03.005},
  volume       = {17},
  year         = {2007},
}